Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
06
2021
revised:
31
07
2021
accepted:
05
08
2021
entrez:
17
9
2021
pubmed:
18
9
2021
medline:
21
1
2022
Statut:
epublish
Résumé
Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on the bioavailability of coumarins; therefore, further investigations are necessitated to study the bioavailability of different coumarins which already showed good biological activities in previous studies. On the evidence of varied pharmacological properties, the present work presents an overall review of the derivation, availability, and biological capacities of coumarins with further consideration of the essential mode of their therapeutic actions. In conclusion, a wide variety of coumarins are available, and their pharmacological activities are of current interest thanks to their synthetic accessibility and riches in medicinal plants. Coumarins perform the valuable function as therapeutic agents in a range of medical fields.
Identifiants
pubmed: 34531939
doi: 10.1155/2021/6492346
pmc: PMC8440074
doi:
Substances chimiques
Anti-Infective Agents
0
Anti-Inflammatory Agents
0
Antineoplastic Agents
0
Coumarins
0
Protective Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6492346Informations de copyright
Copyright © 2021 Javad Sharifi-Rad et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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