Human genomics of the humoral immune response against polyomaviruses.
GWAS
genomics
human
infection
meta-analysis
polyomavirus
Journal
Virus evolution
ISSN: 2057-1577
Titre abrégé: Virus Evol
Pays: England
ID NLM: 101664675
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
02
2021
revised:
30
04
2021
accepted:
09
06
2021
entrez:
17
9
2021
pubmed:
18
9
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta-analyses of qualitative and quantitative immunoglobulin G responses against BK polyomavirus (BKPyV), JC polyomavirus (JCPyV), Merkel cellpolyomavirus (MCPyV), WU polyomavirus (WUPyV), and human polyomavirus 6 (HPyV6) in 15,660 individuals of European ancestry from three independent studies. We observed significant associations for all tested viruses: JCPyV, HPyV6, and MCPyV associated with human leukocyte antigen class II variation, BKPyV and JCPyV with variants in
Identifiants
pubmed: 34532061
doi: 10.1093/ve/veab058
pii: veab058
pmc: PMC8438875
doi:
Types de publication
Journal Article
Langues
eng
Pagination
veab058Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
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