A genome-wide association study identifies
GWAS
Potyvirus
emerging viruses
host-range
specialism-generalism continuum
virus evolution
virus-host interactions
Journal
Virus evolution
ISSN: 2057-1577
Titre abrégé: Virus Evol
Pays: England
ID NLM: 101664675
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
02
2021
revised:
23
06
2021
accepted:
30
06
2021
entrez:
17
9
2021
pubmed:
18
9
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Viruses lie in a continuum between generalism and specialism depending on their ability to infect more or less hosts. While generalists are able to successfully infect a wide variety of hosts, specialists are limited to one or a few. Even though generalists seem to gain an advantage due to their wide host range, they usually pay a pleiotropic fitness cost within each host. On the contrary, a specialist has maximal fitness within its own host. A relevant yet poorly explored question is whether viruses differ in the way they interact with their hosts' gene expression depending on their degree of specialization. Using a genome-wide association study approach, we have identified host genes whose expression depends on whether hosts were infected with more or less specialized viral strains. Four hundred fifty natural accessions of
Identifiants
pubmed: 34532063
doi: 10.1093/ve/veab063
pii: veab063
pmc: PMC8438913
doi:
Types de publication
Journal Article
Langues
eng
Pagination
veab063Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
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