The role of glucagon-like peptide 1 (GLP-1) in addictive disorders.
GLP-1
addiction
alcohol
alcohol use disorder
amphetamine
cocaine
dopamine
glucagon-like peptide-1
nicotine
opioids
substance use disorder
tobacco
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
21
05
2021
received:
09
03
2021
accepted:
19
06
2021
pubmed:
18
9
2021
medline:
14
4
2022
entrez:
17
9
2021
Statut:
ppublish
Résumé
Drug, alcohol and tobacco use disorders are a global burden affecting millions of people. Despite decades of research, treatment options are sparse or missing, and relapse rates are high. Glucagon-like peptide 1 (GLP-1) is released in the small intestine, promotes blood glucose homeostasis, slows gastric emptying and reduces appetite. GLP-1 receptor agonists approved for treating Type 2 diabetes mellitus and obesity have received attention as a potential anti-addiction treatment. Studies in rodents and non-human primates have demonstrated a reduction in intake of alcohol and drugs of abuse, and clinical trials have been initiated to investigate whether the preclinical findings can be translated to patients. This review will give an overview of current findings and discuss the possible mechanisms of action. We suggest that effects of GLP-1 in alcohol and substance use disorders is mediated centrally, at least partly through dopamine signalling, but precise mechanisms are still to be uncovered. LINKED ARTICLES: This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc.
Identifiants
pubmed: 34532853
doi: 10.1111/bph.15677
pmc: PMC8820218
doi:
Substances chimiques
Glucagon-Like Peptide-1 Receptor
0
Ethanol
3K9958V90M
Glucagon-Like Peptide 1
89750-14-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
625-641Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA025071
Pays : United States
Informations de copyright
© 2021 The British Pharmacological Society.
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