Lithium can mildly increase health during ageing but not lifespan in mice.
ageing
healthspan
lifespan
lithium
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
12
08
2021
received:
18
06
2021
accepted:
05
09
2021
pubmed:
18
9
2021
medline:
19
2
2022
entrez:
17
9
2021
Statut:
ppublish
Résumé
Lithium is a nutritional trace element, used clinically as an anti-depressant. Preclinically, lithium has neuroprotective effects in invertebrates and mice, and it can also extend lifespan in fission yeast, C. elegans and Drosophila. An inverse correlation of human mortality with the concentration of lithium in tap water suggests a possible, evolutionarily conserved mechanism mediating longevity. Here, we assessed the effects of lithium treatment on lifespan and ageing parameters in mice. Lithium has a narrow therapeutic dose range, and overdosing can severely affect organ health. Within the tolerable dosing range, we saw some mildly positive effects of lithium on health span but not on lifespan.
Identifiants
pubmed: 34532960
doi: 10.1111/acel.13479
pmc: PMC8520709
doi:
Substances chimiques
Lithium
9FN79X2M3F
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13479Informations de copyright
© 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Références
Ann Neurol. 2008 Jul;64(1):15-24
pubmed: 18318434
Cell Rep. 2016 Apr 19;15(3):638-650
pubmed: 27068460
Nat Rev Drug Discov. 2020 Aug;19(8):513-532
pubmed: 32467649
J Clin Invest. 2013 Jan;123(1):348-61
pubmed: 23202733
J Clin Invest. 2010 Jul;120(7):2432-45
pubmed: 20530871
Br J Pharmacol. 2009 Jul;157(6):1004-13
pubmed: 19508392
Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20817-20819
pubmed: 31570569
Proc Natl Acad Sci U S A. 2005 May 10;102(19):6990-5
pubmed: 15867159
J Biol Chem. 2008 Jan 4;283(1):350-357
pubmed: 17959600
Mol Psychiatry. 2015 Jun;20(6):661-70
pubmed: 25687772
J Neurol Neurosurg Psychiatry. 1954 Nov;17(4):250-60
pubmed: 13212414
JBMR Plus. 2021 Feb 16;5(3):e10466
pubmed: 33778327
Eur J Nutr. 2011 Aug;50(5):387-9
pubmed: 21301855
Med J Aust. 1949 Sep 3;2(10):349-52
pubmed: 18142718
Int J Immunopharmacol. 1995 Jul;17(7):581-92
pubmed: 8586486
J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):810-20
pubmed: 24398558
Int J Mol Sci. 2020 Dec 27;22(1):
pubmed: 33375448
Front Aging Neurosci. 2014 Jul 30;6:190
pubmed: 25126078
PLoS One. 2010 Dec 20;5(12):e14382
pubmed: 21187954
Brain Res. 2011 Mar 22;1380:106-19
pubmed: 21078304
Am J Pathol. 2014 Oct;184(10):2742-56
pubmed: 25239564
Nat Rev Nephrol. 2009 May;5(5):270-6
pubmed: 19384328
Mech Ageing Dev. 2009 Apr;130(4):253-61
pubmed: 19162061
Br J Ophthalmol. 2013 Aug;97(8):1068-73
pubmed: 23759441
Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1168-F1171
pubmed: 27122541
Aging Cell. 2021 Oct;20(10):e13479
pubmed: 34532960