Low serum levels of bone turnover markers are associated with perirenal fat thickness in patients with type 2 diabetes mellitus.
bone metabolism
perirenal fat thickness
type 2 diabetes
β-C-terminal telopeptides of type I collagen
Journal
Endocrine connections
ISSN: 2049-3614
Titre abrégé: Endocr Connect
Pays: England
ID NLM: 101598413
Informations de publication
Date de publication:
13 Oct 2021
13 Oct 2021
Historique:
received:
07
09
2021
accepted:
17
09
2021
pubmed:
18
9
2021
medline:
18
9
2021
entrez:
17
9
2021
Statut:
epublish
Résumé
Obesity is known as a common risk factor for osteoporosis and type 2 diabetes mellitus (T2DM). Perirenal fat, surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study aimed to explore the relationship between perirenal fat and bone metabolism in patients with T2DM. A total of 234 patients with T2DM were recruited from September 2019 to December 2019 in the cross-sectional study. The biochemical parameters and bone turnover markers (BTMs) were determined in all participants. Perirenal fat thickness (PrFT) was performed by ultrasounds via a duplex Doppler apparatus. Associations between PrFT and bone metabolism index were determined via correlation analysis and regression models. The PrFT was significantly correlated with β-C-terminal telopeptides of type I collagen (β-CTX) (r = -0.14, P < 0.036), parathyroid hormone (iPTH) (r = -0.18, P ≤ 0.006), and 25 hydroxyvitamin D (25-OH-D) (r = -0.14, P = 0.001). Multivariate analysis confirmed that the association of PrFT and β-CTX (β = -0.136, P = 0.042) was independent of other variables. This study showed a negative and independent association between PrFT and β-CTX in subjects with T2DM, suggesting a possible role of PrFT in bone metabolism. Follow-up studies and further research are necessary to validate the associations and to elucidate the underlying mechanisms.
Sections du résumé
BACKGROUND
BACKGROUND
Obesity is known as a common risk factor for osteoporosis and type 2 diabetes mellitus (T2DM). Perirenal fat, surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study aimed to explore the relationship between perirenal fat and bone metabolism in patients with T2DM.
METHODS
METHODS
A total of 234 patients with T2DM were recruited from September 2019 to December 2019 in the cross-sectional study. The biochemical parameters and bone turnover markers (BTMs) were determined in all participants. Perirenal fat thickness (PrFT) was performed by ultrasounds via a duplex Doppler apparatus. Associations between PrFT and bone metabolism index were determined via correlation analysis and regression models.
RESULTS
RESULTS
The PrFT was significantly correlated with β-C-terminal telopeptides of type I collagen (β-CTX) (r = -0.14, P < 0.036), parathyroid hormone (iPTH) (r = -0.18, P ≤ 0.006), and 25 hydroxyvitamin D (25-OH-D) (r = -0.14, P = 0.001). Multivariate analysis confirmed that the association of PrFT and β-CTX (β = -0.136, P = 0.042) was independent of other variables.
CONCLUSION
CONCLUSIONS
This study showed a negative and independent association between PrFT and β-CTX in subjects with T2DM, suggesting a possible role of PrFT in bone metabolism. Follow-up studies and further research are necessary to validate the associations and to elucidate the underlying mechanisms.
Identifiants
pubmed: 34533475
doi: 10.1530/EC-21-0449
pii: EC-21-0449
pmc: PMC8558911
doi:
pii:
Types de publication
Journal Article
Langues
eng
Pagination
1337-1343Références
Nephrol Dial Transplant. 2011 Mar;26(3):892-8
pubmed: 20798120
J Clin Endocrinol Metab. 2013 Feb;98(2):659-67
pubmed: 23345099
J Gerontol A Biol Sci Med Sci. 2004 Sep;59(9):M924-9
pubmed: 15472157
Int J Endocrinol. 2014;2014:820615
pubmed: 25050121
Bone. 2013 Jul;55(1):119-25
pubmed: 23428401
Osteoporos Int. 2011 Feb;22(2):635-45
pubmed: 20533027
Diabetes. 2016 Jul;65(7):1757-66
pubmed: 27329951
Nat Clin Pract Rheumatol. 2006 Jan;2(1):35-43
pubmed: 16932650
J Bone Miner Res. 2000 Aug;15(8):1526-36
pubmed: 10934651
Mol Metab. 2019 Jun;24:30-43
pubmed: 31079959
Bone. 2016 Jan;82:69-78
pubmed: 25722065
J Bone Miner Res. 2008 Jan;23(1):17-29
pubmed: 17784844
Diabetes Care. 2010 Aug;33(8):1766-70
pubmed: 20504896
Medicine (Baltimore). 2017 Dec;96(51):e8811
pubmed: 29390417
J Diabetes Res. 2020 Jun 28;2020:6076145
pubmed: 32685560
J Bone Miner Res. 2011 Jul;26(7):1568-76
pubmed: 21312272
J Clin Endocrinol Metab. 1994 Oct;79(4):950-4
pubmed: 7962303
J Clin Hypertens (Greenwich). 2018 Oct;20(10):1438-1446
pubmed: 30218482
Osteoporos Int. 2017 Nov;28(11):3113-3121
pubmed: 28795239
Angiology. 2019 Aug;70(7):584-593
pubmed: 30301366
J Bone Miner Res. 1997 Jan;12(1):144-51
pubmed: 9240737
Anat Rec (Hoboken). 2012 Jan;295(1):91-104
pubmed: 22144396
Acta Neurobiol Exp (Wars). 2002;62(4):227-34
pubmed: 12659288
BMC Cardiovasc Disord. 2015 Sep 30;15:108
pubmed: 26419359
Int J Obes. 1985;9 Suppl 1:1-6
pubmed: 3934090
Calcif Tissue Int. 1986 Jun;38(6):318-22
pubmed: 3089552
Am J Clin Nutr. 2015 Feb;101(2):337-43
pubmed: 25646331
Cell Metab. 2016 Apr 12;23(4):699-711
pubmed: 27053360
Cell. 2002 Nov 1;111(3):305-17
pubmed: 12419242
J Clin Endocrinol Metab. 2013 Jun;98(6):2562-72
pubmed: 23515452
J Clin Endocrinol Metab. 2015 Jan;100(1):274-81
pubmed: 25343234
J Clin Ultrasound. 2010 May;38(4):190-5
pubmed: 20091697
Calcif Tissue Int. 2019 Nov;105(5):466-475
pubmed: 31511960
Arch Gerontol Geriatr. 1997 Jan-Feb;24(1):15-21
pubmed: 15374132
J Bone Miner Res. 2018 Aug;33(8):1417-1421
pubmed: 29624726