Structure of SARS-CoV-2 spike protein.

Angiotensin-Converting Enzyme 2 / chemistry Binding Sites COVID-19 Vaccines / immunology Protein Domains Spike Glycoprotein, Coronavirus / chemistry

Journal

Current opinion in virology
ISSN: 1879-6265
Titre abrégé: Curr Opin Virol
Pays: Netherlands
ID NLM: 101560941

Informations de publication

Date de publication:
10 2021
Historique:
received: 13 05 2021
revised: 20 08 2021
accepted: 27 08 2021
pubmed: 18 9 2021
medline: 21 10 2021
entrez: 17 9 2021
Statut: ppublish

Résumé

The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and devastating socio-economic consequences worldwide. The disease has created urgent needs for intervention strategies to control the crisis and meeting these needs requires a deep understanding of the structure-function relationships of viral proteins and relevant host factors. The trimeric spike (S) protein of the virus decorates the viral surface and is an important target for development of diagnostics, therapeutics and vaccines. Rapid progress in the structural biology of SARS-CoV-2 S protein has been made since the early stage of the pandemic, advancing our knowledge on the viral entry process considerably. In this review, we summarize our latest understanding of the structure of the SARS-CoV-2 S protein and discuss the implications for vaccines and therapeutics.

Identifiants

DOI: 10.1016/j.coviro.2021.08.010 PMID: 34534731 PMC: PMC8423807
pubmed: 34534731
pii: S1879-6257(21)00097-3
doi: 10.1016/j.coviro.2021.08.010
pmc: PMC8423807
pii:
doi:

Substances chimiques

COVID-19 Vaccines 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

173-182

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI127193
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141002
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147884
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

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Auteurs

Jun Zhang (J)

Division of Molecular Medicine, Boston Children's Hospital, 3 Blackfan Street, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, United States.

Tianshu Xiao (T)

Division of Molecular Medicine, Boston Children's Hospital, 3 Blackfan Street, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, United States.

Yongfei Cai (Y)

Division of Molecular Medicine, Boston Children's Hospital, 3 Blackfan Street, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, United States. Electronic address: ycai@crystal.harvard.edu.

Bing Chen (B)

Division of Molecular Medicine, Boston Children's Hospital, 3 Blackfan Street, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, United States. Electronic address: bchen@crystal.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › Structure of SARS-CoV-2 spike protein.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structure of SARS-CoV-2 spike protein.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la COVID-19 › Structure of SARS-CoV-2 spike protein.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Structure of SARS-CoV-2 spike protein.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › Structure of SARS-CoV-2 spike protein.