Maternal selenium levels and whole genome screen in recurrent spontaneous preterm birth population: A nested case control study.

Case-Control Studies Female Humans Models, Statistical Pregnancy Premature Birth / genetics Prognosis Selenium
Genome wide association study Nutrition Obstetrics Preterm birth Selenium

Journal

European journal of obstetrics, gynecology, and reproductive biology
ISSN: 1872-7654
Titre abrégé: Eur J Obstet Gynecol Reprod Biol
Pays: Ireland
ID NLM: 0375672

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 18 06 2021
accepted: 11 08 2021
pubmed: 18 9 2021
medline: 6 10 2021
entrez: 17 9 2021
Statut: ppublish

Résumé

To establish if low maternal selenium (Se) was associated with sPTB in women with recurrent sPTB and identify genetic link with maternal Se levels. Nested case-control study. Tertiary Maternity Hospital. Plasma and whole blood from pregnant women with history of early sPTB/PPROM < 34 Maternal plasma Se measured by ICP-MS was used as a continuous phenotype in a GWAS analysis. Se was added to a logistic regression model using PTB predictor variables. Maternal Se concentration, recurrent early sPTB/PPROM. 53/177 high-risk women had a recurrent sPTB/PPROM < 34 Low plasma Se is associated with sPTB risk but is not sufficiently predictive at individual patient level. We did not find a genetic association between maternal Se levels and Se-related genes.

Identifiants

DOI: 10.1016/j.ejogrb.2021.08.015 PMID: 34534736
pubmed: 34534736
pii: S0301-2115(21)00415-2
doi: 10.1016/j.ejogrb.2021.08.015
pii:
doi:

Substances chimiques

Selenium H6241UJ22B

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

203-211

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Angharad G Care (AG)

Harris Wellbeing Preterm Birth Research Centre, Department of Women's and Children's Health, University of Liverpool, Liverpool Women's Hospital, Liverpool, United Kingdom. Electronic address: angharad.care@liverpool.ac.uk.

Juhi K Gupta (JK)

Harris Wellbeing Preterm Birth Research Centre, Department of Women's and Children's Health, University of Liverpool, Liverpool Women's Hospital, Liverpool, United Kingdom; Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

Laura Goodfellow (L)

Harris Wellbeing Preterm Birth Research Centre, Department of Women's and Children's Health, University of Liverpool, Liverpool Women's Hospital, Liverpool, United Kingdom.

Ge Zhang (G)

Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics and University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Nagendra Monangi (N)

Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics and University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Elizabeth Belling (E)

Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics and University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Julio Landero (J)

Department of Chemistry, University of Cincinnati, Cincinnati, OH, United States.

Joanne Chappell (J)

Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics and University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Andrew Sharp (A)

Harris Wellbeing Preterm Birth Research Centre, Department of Women's and Children's Health, University of Liverpool, Liverpool Women's Hospital, Liverpool, United Kingdom.

Ana Alfirevic (A)

Harris Wellbeing Preterm Birth Research Centre, Department of Women's and Children's Health, University of Liverpool, Liverpool Women's Hospital, Liverpool, United Kingdom; Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

Bertram Müller-Myhsok (B)

Waterhouse Building, University of Liverpool, Liverpool, United Kingdom; Max Plank Institute of Psychiatry, Munich, Germany.

Louis J Muglia (LJ)

Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics and University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Zarko Alfirevic (Z)

Harris Wellbeing Preterm Birth Research Centre, Department of Women's and Children's Health, University of Liverpool, Liverpool Women's Hospital, Liverpool, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Maternal selenium levels and whole genome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maternal selenium levels and whole genome...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Modèles statistiques › Maternal selenium levels and whole genome...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Maternal selenium levels and whole genome...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications du travail obstétrical › Travail obstétrical prématuré › Naissance prématurée › Maternal selenium levels and whole genome...
questionsmedicales.fr › Diagnostic › Pronostic › Maternal selenium levels and whole genome...
questionsmedicales.fr › Produits chimiques inorganiques › Minéraux › Sélénium › Maternal selenium levels and whole genome...