European Hedgehogs (Erinaceus europaeus L.) as a Reservoir of Dermatophytes in Poland.
Dermatophyte reservoir
Erinaceus europaeus
Prevalence
Urban areas
Wildlife
Zoonoses
Journal
Microbial ecology
ISSN: 1432-184X
Titre abrégé: Microb Ecol
Pays: United States
ID NLM: 7500663
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
22
06
2021
accepted:
07
09
2021
pubmed:
19
9
2021
medline:
8
9
2022
entrez:
18
9
2021
Statut:
ppublish
Résumé
The European hedgehog (Erinaceus europaeus Linnaeus) frequently colonises areas located close to human life in cities, as these are more suitable nest sites offering an abundance of food and allowing avoidance of predators. However, urbanisation has a significant impact on the epidemiology of infectious diseases, including dermatophytoses, the primary source of which are wild animals. In this study, we determined the spectrum of dermatophytes isolated from the European hedgehog and assessed their susceptibility profile to antifungal drugs. Symptomatic and asymptomatic dermatophyte infections were observed in 7.7% and 8% of the 182 examined free-living hedgehogs, respectively. In the pool of the isolated dermatophyte strains, Trichophyton erinacei was dominant (29.9%), followed by Trichophyton mentagrophytes (17.9%), Trichophyton benhamiae (13.4%), Nannizzia gypsea (11.9%), Microsporum canis (10.4%), Nannizzia nana (7.5%), Paraphyton cookei (6.0%), and Nannizzia fulva (3.0%). Susceptibility tests revealed the highest activity of luliconazole and the lowest of activity fluconazole among the azole drugs applied. Although terbinafine generally exhibited high efficacy, two Trichophyton mentagrophytes isolates showed resistance to this drug (MIC = 2 µg/ml) resulting from missense mutations in the SQLE gene corresponding to the amino acid substitution Leu393Phe. Summarising, our study has also revealed that such wildlife animals as hedgehogs can be a reservoir of pathogenic human dermatophytes, including harmful strains resistant to commonly used antifungal drugs.
Identifiants
pubmed: 34536095
doi: 10.1007/s00248-021-01866-w
pii: 10.1007/s00248-021-01866-w
pmc: PMC9436838
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-375Informations de copyright
© 2021. The Author(s).
Références
Dermatol Clin. 2003 Apr;21(2):229-36
pubmed: 12757244
Mycoses. 1997 Nov;40(7-8):317-20
pubmed: 9476517
J Mycol Med. 2019 Dec;29(4):352-355
pubmed: 31611164
Clin Exp Dermatol. 1992 May;17(3):156-8
pubmed: 1451288
Mycoses. 2018 Jul;61(7):477-484
pubmed: 29577447
Sabouraudia. 1963 Oct;3(1):1-10
pubmed: 5875362
Vet Dermatol. 2009 Feb;20(1):13-8
pubmed: 18699813
Infection. 2020 Dec;48(6):889-897
pubmed: 32770418
Pathogens. 2019 Sep 30;8(4):
pubmed: 31575004
Mycopathologia. 2017 Feb;182(1-2):5-31
pubmed: 27783317
Antimicrob Agents Chemother. 2019 Sep 23;63(10):
pubmed: 31383665
Case Rep Dermatol. 2019 Jul 2;11(2):198-203
pubmed: 31341462
South Med J. 2000 Sep;93(9):936-8
pubmed: 11005362
J Fungi (Basel). 2021 Jan 21;7(2):
pubmed: 33494368
Med Mycol. 2019 Feb 1;57(2):171-180
pubmed: 29534233
Mycopathologia. 2021 May;186(2):163-176
pubmed: 33523393
Med Mycol. 2005 Jun;43(4):373-9
pubmed: 16110784
Vet Clin North Am Small Anim Pract. 1994 Jan;24(1):113-20
pubmed: 8109070
Rev Argent Microbiol. 2008 Jul-Sep;40(3):161-3
pubmed: 19024503
Vet Microbiol. 2017 Jun;205:106-109
pubmed: 28622851
Mycoses. 2018 Dec;61(12):945-953
pubmed: 30030967
Rev Inst Med Trop Sao Paulo. 2009 Jan-Feb;51(1):9-12
pubmed: 19229384
Eur J Clin Microbiol Infect Dis. 2020 Nov;39(11):2099-2113
pubmed: 32607909
Trends Ecol Evol. 2017 Jan;32(1):55-67
pubmed: 28029378
J Am Acad Dermatol. 2018 Dec;79(6):1145-1146
pubmed: 29860042
Antimicrob Agents Chemother. 2017 Jun 27;61(7):
pubmed: 28416557
Eur J Cancer Care (Engl). 2001 Mar;10(1):56-62
pubmed: 11827268
Antimicrob Agents Chemother. 2018 Apr 26;62(5):
pubmed: 29530857
J Med Microbiol. 2019 Jun;68(6):823-836
pubmed: 31050630
Transbound Emerg Dis. 2020 Nov;67(6):2702-2712
pubmed: 32406160
J Appl Microbiol. 2017 May;122(5):1368-1379
pubmed: 28236353
Mycoses. 2021 May;64(5):537-549
pubmed: 33448025
Emerg Infect Dis. 2005 Jan;11(1):1-5
pubmed: 15705314
Rev Iberoam Micol. 2020 Jul - Oct;37(3-4):94-96
pubmed: 32988737
Nature. 1960 Dec 3;188:867-8
pubmed: 13767053
J Appl Microbiol. 2021 Jan;130(1):278-291
pubmed: 32650353
J Appl Microbiol. 2021 Nov;131(5):2095-2113
pubmed: 33556223
Sci Rep. 2018 Sep 6;8(1):12156
pubmed: 30190482
Sabouraudia. 1969 Jun;7(2):118-21
pubmed: 5346185
J Dermatol. 2019 Apr;46(4):351-353
pubmed: 30768808
Vet Dermatol. 2016 Dec;27(6):500-e133
pubmed: 27620985
Arch Dermatol. 1999 May;135(5):561-3
pubmed: 10328197
J Appl Microbiol. 2021 Dec;131(6):2688-2704
pubmed: 33754409
Antimicrob Agents Chemother. 2006 Jun;50(6):2234-6
pubmed: 16723593
Adv Biomed Res. 2019 Jun 28;8:38
pubmed: 31360679
Mycopathologia. 2010 Dec;170(6):417-21
pubmed: 20574717
Ecol Evol. 2019 Oct 31;9(23):13174-13187
pubmed: 31871637
Antimicrob Agents Chemother. 2005 Jul;49(7):2840-4
pubmed: 15980358
Mycopathologia. 2017 Aug;182(7-8):691-699
pubmed: 28108868
Infection. 2020 Jun;48(3):429-434
pubmed: 32232786
Med Mycol Case Rep. 2019 Sep 18;26:23-24
pubmed: 31667055
Antimicrob Agents Chemother. 2003 Jan;47(1):82-6
pubmed: 12499173
Braz J Microbiol. 2013 May 31;44(1):171-4
pubmed: 24159301
Mycopathologia. 2015 Aug;180(1-2):61-8
pubmed: 25690159
J Fungi (Basel). 2021 Apr 28;7(5):
pubmed: 33925095
J Dermatol. 2021 Apr;48(4):564-567
pubmed: 33439506