The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria.


Journal

Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028

Informations de publication

Date de publication:
03 2022
Historique:
revised: 31 08 2021
received: 24 06 2021
accepted: 06 09 2021
pubmed: 19 9 2021
medline: 9 4 2022
entrez: 18 9 2021
Statut: ppublish

Résumé

This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease that presents with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous or inducible urticaria is disabling, impairs quality of life, and affects performance at work and school. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.

Identifiants

pubmed: 34536239
doi: 10.1111/all.15090
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

734-766

Informations de copyright

© 2021 GA²LEN. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Références

Zuberbier T, Asero R, Bindslev-Jensen C, et al. EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy. 2009;64(10):1417-1426. doi:10.1111/j.1398-9995.2009.02179.x
Zuberbier T, Asero R, Bindslev-Jensen C, et al. EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria. Allergy. 2009;64(10):1427-1443. doi:10.1111/j.1398-9995.2009.02178.x
Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update. Allergy. 2014;69(7):868-887. doi:10.1111/all.12313
Zuberbier T, Aberer W, Asero R, et al. Methods report on the development of the 2013 revision and update of the EAACI/GA2 LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2014;69(7). doi:10.1111/all.12370
AGREE Next Steps Consortium. The AGREE II Instrument. http://www.agreetrust.org. Accessed January 12, 2015.
Higgins JPT, Green S, Cochrane C. Cochrane handbook for systematic reviews of interventions. Cochrane Collaboration. http://training.cochrane.org/handbook. Accessed: 27 September 2021.
Dressler C, Rosumeck S, Werner RN, et al. Executive summary of the methods report for ‘The EAACI/GA(2) LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. The 2017 Revision and Update’. Allergy. 2018;73(5):1145-1146. doi:10.1111/all.13414
Nordic Cochrane Centre. Review Manager (RevMan) [Computer program]. Version 5.3. The Cochrane Collaboration; 2014.
Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328(7454):1490. doi:10.1136/bmj.328.7454.1490
GRADEpro GDT: GRADEpro Guideline Development Tool. McMaster University (developed by Evidence Prime, Inc.); 2015.
Jones J, Hunter D. Consensus methods for medical and health services research. BMJ. 1995;311(7001):376-380.
Kaplan AP, Garofalo J. Identification of a new physically induced urticaria: cold-induced cholinergic urticaria. J Allergy Clin Immunol. 1981;68(6):438-441. doi:10.1016/s0091-6749(81)90209-8
Church MK, Kolkhir P, Metz M, Maurer M. The role and relevance of mast cells in urticaria. Immunol Rev. 2018;282(1):232-247. doi:10.1111/imr.12632
Haas N, Schadendorf D, Henz BM. Differential endothelial adhesion molecule expression in early and late whealing reactions. Int Arch Allergy Immunol. 1998;115(3):210-214.
Peteiro C, Toribio J. Incidence of leukocytoclastic vasculitis in chronic idiopathic urticaria. Study of 100 cases. Am J Dermatopathol. 1989;11(6):528-533.
Ito Y, Satoh T, Takayama K, Miyagishi C, Walls AF, Yokozeki H. Basophil recruitment and activation in inflammatory skin diseases. Allergy. 2011;66(8):1107-1113. doi:10.1111/j.1398-9995.2011.02570.x
Kay AB, Clark P, Maurer M, Ying S. Elevations in T-helper-2-initiating cytokines (interleukin-33, interleukin-25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous (‘idiopathic’) urticaria. Br J Dermatol. 2015;172(5):1294-1302. doi:10.1111/bjd.13621
Kay AB, Ying S, Ardelean E, et al. Calcitonin gene-related peptide and vascular endothelial growth factor are expressed in lesional but not uninvolved skin in chronic spontaneous urticaria. Clin Exp Allergy. 2014;44(8):1053-1060. doi:10.1111/cea.12348
Kay AB, Ying S, Ardelean E, et al. Elevations in vascular markers and eosinophils in chronic spontaneous urticarial weals with low-level persistence in uninvolved skin. Br J Dermatol. 2014;171(3):505-511. doi:10.1111/bjd.12991
Greaves MW. Chronic urticaria. N Engl J Med. 1995;332(26):1767-1772. doi:10.1056/NEJM199506293322608
Kaplan AP. Clinical practice. Chronic urticaria and angioedema. N Engl J Med. 2002;346(3):175-179. doi:10.1056/NEJMcp011186
Hermes B, Prochazka AK, Haas N, Jurgovsky K, Sticherling M, Henz BM. Upregulation of TNF-alpha and IL-3 expression in lesional and uninvolved skin in different types of urticaria. J Allergy Clin Immunol. 1999;103(2 Pt 1):307-314.
Maurer M, Weller K, Bindslev-Jensen C, et al. Unmet clinical needs in chronic spontaneous urticaria. A GA(2)LEN task force report. Allergy. 2011;66(3):317-330. doi:10.1111/j.1398-9995.2010.02496.x
Gonçalo M, Gimenéz-Arnau A, Al-Ahmad M, et al. The global burden of chronic urticaria for the patient and society. Br J Dermatol. 2021;184(2):226-236. doi:10.1111/bjd.19561
Baiardini I, Braido F, Bindslev-Jensen C, et al. Recommendations for assessing patient-reported outcomes and health-related quality of life in patients with urticaria: a GA(2) LEN taskforce position paper. Allergy. 2011;66(7):840-844. doi:10.1111/j.1398-9995.2011.02580.x
Maurer M, Staubach P, Raap U, et al. H1-antihistamine-refractory chronic spontaneous urticaria: it's worse than we thought - first results of the multicenter real-life AWARE study. Clin Exp Allergy. 2017;47(5):684-692. doi:10.1111/cea.12900
Maurer M, Staubach P, Raap U, Richter-Huhn G, Baier-Ebert M, Chapman-Rothe N. ATTENTUS, a German online survey of patients with chronic urticaria highlighting the burden of disease, unmet needs and real-life clinical practice. Br J Dermatol. 2016;174(4):892-894. doi:10.1111/bjd.14203
Maurer M, Abuzakouk M, Bérard F, et al. The burden of chronic spontaneous urticaria is substantial: real-world evidence from ASSURE-CSU. Allergy. 2017;72(12):2005-2016. doi:10.1111/all.13209
O'Donnell BF, Lawlor F, Simpson J, Morgan M, Greaves MW. The impact of chronic urticaria on the quality of life. Br J Dermatol. 1997;136(2):197-201.
Baiardini I, Giardini A, Pasquali M, et al. Quality of life and patients' satisfaction in chronic urticaria and respiratory allergy. Allergy. 2003;58(7):621-623.
Parisi CA, Ritchie C, Petriz N, Morelo TC. Direct Medical Costs of Chronic Urticaria in a Private Health Organization of Buenos Aires, Argentina. Value Health Reg Issues. 2016;11:57-59. doi:10.1016/j.vhri.2016.07.008
Broder MS, Raimundo K, Antonova E, Chang E. Resource use and costs in an insured population of patients with chronic idiopathic/spontaneous urticaria. Am J Clin Dermatol. 2015;16(4):313-321. doi:10.1007/s40257-015-0134-8
Graham J, McBride D, Stull D, et al. Cost utility of omalizumab compared with standard of care for the treatment of chronic spontaneous urticaria. Pharmacoeconomics. 2016;34(8):815-827. doi:10.1007/s40273-016-0412-1
Metz M, Altrichter S, Buttgereit T, et al. Diagnostic workup in chronic spontaneous urticaria - what to test and why? J Allergy Clin Immunol Pract. 2021;9:2274-2283.
Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393-1414. doi:10.1111/all.13397
Curto-Barredo L, Archilla LR, Vives GR, Pujol RM, Giménez-Arnau AM. Clinical features of chronic spontaneous urticaria that predict disease prognosis and refractoriness to standard treatment. Acta Derm Venereol. 2018;98(7):641-647. doi:10.2340/00015555-2941
Fok JS, Kolkhir P, Church MK, Maurer M. Predictors of treatment response in chronic spontaneous urticaria. Allergy. 2021;76:2965-2981. doi:10.1111/all.14757
Maurer M, Eyerich K, Eyerich S, et al. Urticaria: collegium internationale allergologicum (CIA) update 2020. Int Arch Allergy Immunol. 2020;181(5):321-333. doi:10.1159/000507218
Weller K, Zuberbier T, Maurer M. Clinically relevant outcome measures for assessing disease activity, disease control and quality of life impairment in patients with chronic spontaneous urticaria and recurrent angioedema. Curr Opin Allergy Clin Immunol. 2015;15(3):220-226. doi:10.1097/aci.0000000000000163
Mlynek A, Zalewska-Janowska A, Martus P, Staubach P, Zuberbier T, Maurer M. How to assess disease activity in patients with chronic urticaria? Allergy. 2008;63(6):777-780.
Hawro T, Ohanyan T, Schoepke N, et al. Comparison and interpretability of the available urticaria activity scores. Allergy. 2017;73(1):251-255. doi:10.1111/all.13271
Weller KG, Magerl M, Tohme M, et al. Development, validation and initial results of the angioedema activity score. Allergy. 2013;68(9):1185-1192.
Ohanyan T, Schoepke N, Bolukbasi B, et al. Responsiveness and minimal important difference of the urticaria control test. J Allergy Clin Immunol. 2017;140(6):1710-1713. doi:10.1016/j.jaci.2017.04.050
Weller K, Groffik A, Church MK, et al. Development and validation of the Urticaria Control Test: a patient-reported outcome instrument for assessing urticaria control. J Allergy Clin Immunol. 2014;133(5):1365-1372. doi:10.1016/j.jaci.2013.12.1076
Magerl M, Altrichter S, Borzova E, et al. The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision. Allergy. 2016;71(6):780-802. doi:10.1111/all.12884
Magerl M, Abajian M, Krause K, Altrichter S, Siebenhaar F, Church MK. An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria. J Eur Acad Dermatol Venereol. 2015;29(10):2043-2045. doi:10.1111/jdv.12739
Schoepke N, Abajian M, Church MK, Magerl M. Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. Clin Exp Dermatol. 2015;40(4):399-403. doi:10.1111/ced.12547
Mlynek A, Vieira dos Santos R, Ardelean E, et al. A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism. Clin Exp Dermatol. 2013;38(4):360-366; quiz 366. doi:10.1111/ced.12107
Altrichter S, Salow J, Ardelean E, Church MK, Werner A, Maurer M. Development of a standardized pulse-controlled ergometry test for diagnosing and investigating cholinergic urticaria. J Dermatol Sci. 2014;75(2):88-93. doi:10.1016/j.jdermsci.2014.04.007
Koch K, Weller K, Werner A, Maurer M, Altrichter S. Antihistamine updosing reduces disease activity in patients with difficult-to-treat cholinergic urticaria. J Allergy Clin Immunol. 2016;138(5):1483-1485. doi:10.1016/j.jaci.2016.05.026
Ruft J, Asady A, Staubach P, et al. Development and validation of the Cholinergic Urticaria Quality-of-Life Questionnaire (CholU-QoL). Clin Exp Allergy. 2018;48(4):433-444. doi:10.1111/cea.13102
Azkur D, Civelek E, Toyran M, et al. Clinical and etiologic evaluation of the children with chronic urticaria. Allergy Asthma Proc. 2016;37(6):450-457.
Lee SJ, Ha EK, Jee HM, et al. Prevalence and risk factors of urticaria with a focus on chronic urticaria in children. Allergy Asthma Immunol Res. 2017;9(3):212-219. doi:10.4168/aair.2017.9.3.212
Church MK, Weller K, Stock P, Maurer M. Chronic spontaneous urticaria in children: itching for insight. Pediatr Allergy Immunol. 2011;22(1 Pt 1):1-8. doi:10.1111/j.1399-3038.2010.01120.x
Maurer M, Church MK, Weller K. Chronic urticaria in children - still itching for insight. JAMA Dermatol. 2017;153(12):1221-1222.
Fricke J, Ávila G, Keller T, et al. Prevalence of chronic urticaria in children and adults across the globe: systematic review with meta-analysis. Allergy. 2020;75(2):423-432. doi:10.1111/all.14037
Balp MM, Weller K, Carboni V, et al. Prevalence and clinical characteristics of chronic spontaneous urticaria in pediatric patients. Pediatr Allergy Immunol. 2018;29(6):630-636. doi:10.1111/pai.12910
Sackesen C, Sekerel BE, Orhan F, Kocabas CN, Tuncer A, Adalioglu G. The etiology of different forms of urticaria in childhood. Pediatr Dermatol. 2004;21(2):102-108. doi:10.1111/j.0736-8046.2004.21202.x
Staubach P, Mann C, Peveling-Oberhag A, et al. Epidemiology of urticaria in German children. J Dtsch Dermatol Ges. 2021;19(7):1013-1019. doi:10.1111/ddg.14485
Kuemmerle-Deschner JB, Ozen S, Tyrrell PN, et al. Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS). Ann Rheum Dis. 2017;76(6):942-947. doi:10.1136/annrheumdis-2016-209686
Grattan CE, Francis DM, Slater NG, Barlow RJ, Greaves MW. Plasmapheresis for severe, unremitting, chronic urticaria. Lancet. 1992;339(8801):1078-1080. doi:10.1016/0140-6736(92)90666-Q
Kowalski ML, Woessner K, Sanak M. Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug-related urticaria and angioedema. J Allergy Clin Immunol. 2015;136(2):245-251. doi:10.1016/j.jaci.2015.06.021
Shakouri A, Compalati E, Lang DM, Khan DA. Effectiveness of Helicobacter pylori eradication in chronic urticaria: evidence-based analysis using the Grading of Recommendations Assessment, Development, and Evaluation system. Curr Opin Allergy Clin Immunol. 2010;10(4):362-369. doi:10.1097/ACI.0b013e32833c79d7
Ishaq S, Nunn L. Helicobacter pylori and gastric cancer: a state of the art review. Gastroenerol Hepatol Bed Bench. 2015;8(Suppl1):6-14.
Henz BM, Zuberbier T. Causes of urticaria. In: Henz BM, Zuberbier T, Grabbe J, Monroe E, eds. Urticaria. Springer; 1998.
Ergon MC, iĺknur T, Yućesoy M, Oźkan Ş. Candida spp. colonization and serum anticandidal antibody levels in patients with chronic urticaria. Clin Exp Dermatol. 2007;32(6):740-743. doi:10.1111/j.1365-2230.2007.02512.x
Zuberbier T, ChantraineKess S, Hartmann K, Czarnetzki BM. Pseudoallergen-free diet in the treatment of chronic urticaria - A prospective study. Acta Derm Venereol. 1995;75(6):484-487.
Bruno G, Andreozzi P. U. G. Exercise-induced urticaria-angioedema syndrome: A role in gastroesophageal reflux. In: Vena GAPP, editor. Proceedings of the international symposium on urticaria. Editrice CSH, Milan. 1998:85-89.
Zheleznov S, Urzhumtseva G, Petrova N, et al. Gastritis can cause and trigger chronic spontaneous urticaria independent of the presence of Helicobacter pylori. Int Arch Allergy Immunol. 2018;175(4):246-251. doi:10.1159/000487669
Varghese R, Rajappa M, Chandrashekar L, et al. Association among stress, hypocortisolism, systemic inflammation, and disease severity in chronic urticaria. Ann Allergy Asthma Immunol. 2016;116(4):344-348. doi:10.1016/j.anai.2016.01.016
Grattan CE, O'Donnell BF, Francis DM, et al. Randomized double-blind study of cyclosporin in chronic ‘idiopathic’ urticaria. Br J Dermatol. 2000;143(2):365-372.
Zuberbier T, Chantraine-Hess S, Hartmann K, Czarnetzki BM. Pseudoallergen-free diet in the treatment of chronic urticaria. A prospective study. Acta Derm Venereol. 1995;75(6):484-487.
Juhlin L. Recurrent urticaria: clinical investigation of 330 patients. Br J Dermatol. 1981;104(4):369-381.
Pfrommer CBR, Vieths S, Ehlers I, Henz BM, Zuberbier T. Characterization of naturally occurring pseudoallergens causing chronic urticaria. J Allergy Clin Immunol. 1996;97(367).
Pigatto PD, Valsecchi RH. Chronic urticaria: a mystery. Allergy. 2000;55(3):306-308.
Bunselmeyer B, Laubach HJ, Schiller M, Stanke M, Luger TA, Brehler R. Incremental build-up food challenge-a new diagnostic approach to evaluate pseudoallergic reactions in chronic urticaria: a pilot study: stepwise food challenge in chronic urticaria. Clin Exp Allergy. 2009;39(1):116-126.
Nettis E, Colanardi MC, Ferrannini A, Tursi A. Sodium benzoate-induced repeated episodes of acute urticaria/angio-oedema: randomized controlled trial. Br J Dermatol. 2004;151(4):898-902. doi:10.1111/j.1365-2133.2004.06095.x
Akoglu G, Atakan N, Cakir B, Kalayci O, Hayran M. Effects of low pseudoallergen diet on urticarial activity and leukotriene levels in chronic urticaria. Arch Dermatol Res. 2012;304(4):257-262. doi:10.1007/s00403-011-1203-3
Wagner N, Dirk D, Peveling-Oberhag A, et al. A Popular myth - low-histamine diet improves chronic spontaneous urticaria - fact or fiction? J Eur Acad Dermatol Venereol. 2016;31(4):650-655.
Beissert S, Stander H, Schwarz T. UVA rush hardening for the treatment of solar urticaria. J Am Acad Dermatol. 2000;42(6):1030-1032.
Grob JJ, Auquier P, Dreyfus I, Ortonne JP. How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life. Allergy. 2009;64(4):605-612. doi:10.1111/j.1398-9995.2008.01913.x
Weller K, Ardelean E, Scholz E, Martus P, Zuberbier T, Maurer M. Can on-demand non-sedating antihistamines improve urticaria symptoms? A double-blind, randomized, single-dose study. Acta Derm Venereol. 2013;93(2):168-174. doi:10.2340/00015555-1434
Church MK, Maurer M, Simons FE, et al. Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy. 2010;65(4):459-466. doi:10.1111/j.1398-9995.2009.02325.x
Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63(Suppl 86):8-160. doi:10.1111/j.1398-9995.2007.01620.x
Kubo N, Senda M, Ohsumi Y, et al. Brain histamine H1 receptor occupancy of loratadine measured by positron emission topography: comparison of H1 receptor occupancy and proportional impairment ratio. Hum Psychopharmacol. 2011;26(2):133-139. doi:10.1002/hup.1184
Kontou-Fili K, Paleologos G, Herakleous M. Suppression of histamine-induced skin reactions by loratadine and cetirizine diHCl. Eur J Clin Pharmacol. 1989;36(6):617-619.
Zuberbier T, Munzberger C, Haustein U, et al. Double-blind crossover study of high-dose cetirizine in cholinergic urticaria. Dermatology. 1996;193(4):324-327.
Kontou-Fili KM, Demaka P, Paleologos G. Therapeutic effect of cetirizine 2 HCl in delayed pressure urticaria. Health Sci Rev. 1989;3:23-25.
Wanderer AA, Ellis EF. Treatment of cold urticaria with cyproheptadine. J Allergy Clin Immunol. 1971;48(6):366-371. doi:10.1016/0091-6749(71)90083-2
Kaplan AP, Gray L, Shaff RE, Horakova Z, Beaven MA. In vivo studies of mediator release in cold urticaria and cholinergic urticaria. J Allergy Clin Immunol. 1975;55(6):394-402. doi:10.1016/0091-6749(75)90078-0
Staevska M, Popov TA, Kralimarkova T, et al. The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria. J Allergy Clin Immunol. 2010;125(3):676-682. doi:10.1016/j.jaci.2009.11.047
Siebenhaar F, Degener F, Zuberbier T, Martus P, Maurer M. High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study. J Allergy Clin Immunol. 2009;123(3):672-679.
Gimenez-Arnau A, Izquierdo I, Maurer M. The use of a responder analysis to identify clinically meaningful differences in chronic urticaria patients following placebo- controlled treatment with rupatadine 10 and 20 mg. J Eur Acad Dermatol Venereol. 2009;23(9):1088-1091. doi:10.1111/j.1468-3083.2009.03289.x
Guillen-Aguinaga S, Jauregui Presa I, Aguinaga-Ontoso E, Guillen-Grima F, Ferrer M. Updosing nonsedating antihistamines in patients with chronic spontaneous urticaria: a systematic review and meta-analysis. Br J Dermatol. 2016;175(6):1153-1165. doi:10.1111/bjd.14768
Saini S, Rosen KE, Hsieh HJ, et al. A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H-1-antihistamine-refractory chronic idiopathic urticaria. J Allergy Clin Immunol. 2011;128(3):567-573. doi:10.1016/j.jaci.2011.06.010
Maurer M, Altrichter S, Bieber T, et al. Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase. J Allergy Clin Immunol. 2011;128(1):202-209. doi:10.1016/j.jaci.2011.04.038
Saini SS, Bindslev-Jensen C, Maurer M, et al. Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on H1 antihistamines: a randomized, placebo-controlled study. J Invest Dermatol. 2015;135(1):67-75. doi:10.1038/jid.2014.306
Maurer M, Rosen K, Hsieh HJ, et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med. 2013;368(10):924-935. doi:10.1056/NEJMoa1215372
Kaplan A, Ledford D, Ashby M, et al. Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy. J Allergy Clin Immunol. 2013;132(1):101-109. doi:10.1016/j.jaci.2013.05.013
Zhao ZT, Ji CM, Yu WJ, et al. Omalizumab for the treatment of chronic spontaneous urticaria: a meta-analysis of randomized clinical trials. J Allergy Clin Immunol. 2016;137(6):1742-1750. doi:10.1016/j.jaci.2015.12.1342
Maurer M, Metz M, Brehler R, et al. Omalizumab treatment in chronic inducible urticaria: a systematic review of published evidence. J Allergy Clin Immunol. 2017;141:638-649. doi:10.1016/j.jaci.2017.06.032
Metz M, Altrichter S, Ardelean E, et al. Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. Int Arch Allergy Immunol. 2011;154(2):177-180. doi:10.1159/000320233
Exposito-Serrano V, Curto-Barredo L, Aguilera Peiro P, et al. Omalizumab for the treatment of chronic inducible urticaria in 80 patients. Br J Dermatol. 2021;184(1):167-168. doi:10.1111/bjd.19425
Metz M, Bergmann P, Zuberbier T, Maurer M. Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy. Allergy. 2008;63(2):247-249.
Boyce JA. Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE. J Allergy Clin Immunol. 2006;117(6):1415-1418. doi:10.1016/j.jaci.2006.04.003
Metz M, Schutz A, Weller K, et al. Omalizumab is effective in cold urticaria-results of a randomized placebo-controlled trial. J Allergy Clin Immunol. 2017;140(3):864-867. doi:10.1016/j.jaci.2017.01.043
Guzelbey O, Ardelean E, Magerl M, Zuberbier T, Maurer M, Metz M. Successful treatment of solar urticaria with anti-immunoglobulin E therapy. Allergy. 2008;63(11):1563-1565.
Bullerkotte U, Wieczorek D, Kapp A, Wedi B. Effective treatment of refractory severe heat urticaria with omalizumab. Allergy. 2010;65(7):931-932. doi:10.1111/j.1398-9995.2009.02268.x
Krause K, Ardelean E, Kessler B, et al. Antihistamine-resistant urticaria factitia successfully treated with anti-immunoglobulin E therapy. Allergy. 2010;65(11):1494-1495. doi:10.1111/j.1398-9995.2010.02409.x
Maurer M, Schütz A, Weller K, et al. Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. J Allergy Clin Immunol. 2017;140(3):870-873. doi:10.1016/j.jaci.2017.01.042
Bindslev-Jensen C, Skov PS. Efficacy of omalizumab in delayed pressure urticaria: a case report. Allergy. 2010;65(1):138-139. doi:10.1111/j.1398-9995.2009.02188.x
Staubach P, Metz M, Chapman-Rothe N, et al. Effect of omalizumab on angioedema in H1 -antihistamine-resistant chronic spontaneous urticaria patients: results from X-ACT, a randomized controlled trial. Allergy. 2016;71(8):1135-1144. doi:10.1111/all.12870
Finlay AY, Kaplan AP, Beck LA, et al. Omalizumab substantially improves dermatology-related quality of life in patients with chronic spontaneous urticaria. J Eur Acad Dermatol Venereol. 2017;31(10):1715-1721. doi:10.1111/jdv.14384
Maurer M, Sofen H, Ortiz B, Kianifard F, Gabriel S, Bernstein JA. Positive impact of omalizumab on angioedema and quality of life in patients with refractory chronic idiopathic/spontaneous urticaria: analyses according to the presence or absence of angioedema. J Eur Acad Dermatol Venereol. 2017;31(6):1056-1063. doi:10.1111/jdv.14075
Maurer M, Kaplan A, Rosén K, et al. The XTEND-CIU study: long term use of Omalizumab in Chronic Idiopathic Urticaria. J Allergy Clin Immunol. 2017;141(3):1138-1139.
Metz M, Ohanyan T, Church MK, Maurer M. Retreatment with omalizumab results in rapid remission in chronic spontaneous and inducible urticaria. JAMA Dermatol. 2014;150(3):288-290. doi:10.1001/jamadermatol.2013.8705
Saini S, Rosen KE, Hsieh HJ, et al. A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H-1-antihistamine-refractory chronic idiopathic urticaria. J Allergy Clin Immunol. 2011;128(3):567. doi:10.1016/j.jaci.2011.06.010
Summary of Product Characteristics - Xolair (omalizumab). Novartis Europharm Limited. [Date of issue of marketing authorisation 25 Oct 2005].
Metz M, Vadasz Z, Kocatürk E, Giménez-Arnau AM. Omalizumab updosing in chronic spontaneous urticaria: an overview of real-world evidence. Clin Rev Allergy Immunol. 2020;59(1):38-45. doi:10.1007/s12016-020-08794-6
Curto-Barredo L, Spertino J, Figueras-Nart I, et al. Omalizumab updosing allows disease activity control in patients with refractory chronic spontaneous urticaria. Br J Dermatol. 2018;179(1):210-212. doi:10.1111/bjd.16379
Kocatürk E, Deza G, Kızıltaç K, Giménez-Arnau AM. Omalizumab updosing for better disease control in chronic spontaneous urticaria patients. Int Arch Allergy Immunol. 2018;177(4):360-364. doi:10.1159/000491530
Stellato C, de Paulis A, Ciccarelli A, et al. Anti-inflammatory effect of cyclosporin A on human skin mast cells. J Invest Dermatol. 1992;98(5):800-804.
Harrison CA, Bastan R, Peirce MJ, Munday MR, Peachell PT. Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506. Br J Pharmacol. 2007;150(4):509-518. doi:10.1038/sj.bjp.0707002
Vena GA, Cassano N, Colombo D, Peruzzi E, Pigatto P. Cyclosporine in chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial. J Am Acad Dermatol. 2006;55(4):705-709. doi:10.1016/j.jaad.2006.04.078
Kulthanan K, Chaweekulrat P, Komoltri C, et al. Cyclosporine for chronic spontaneous urticaria: a meta-analysis and systematic review. J Allergy Clin Immunol Pract. 2018;6:586-599.
Doshi DR, Weinberger MM. Experience with cyclosporine in children with chronic idiopathic urticaria. Pediatr Dermatol. 2009;26(4):409-413. doi:10.1111/j.1525-1470.2009.00869.x
Zuberbier T, Ifflander J, Semmler C, Henz BM. Acute urticaria: clinical aspects and therapeutic responsiveness. Acta Derm Venereol. 1996;76(4):295-297.
Asero R, Tedeschi A. Usefulness of a short course of oral prednisone in antihistamine-resistant chronic urticaria: a retrospective analysis. J Invest Allerg Clin. 2010;20(5):386-390.
Rutkowski K, Grattan CEH. How to manage chronic urticaria ‘beyond’ guidelines: a practical algorithm. Clin Exp Allergy. 2017;47(6):710-718.
Magerl M, Philipp S, Manasterski M, Friedrich M, Maurer M. Successful treatment of delayed pressure urticaria with anti-TNF-alpha. J Allergy Clin Immun. 2007;119(3):752-754. doi:10.1016/j.jaci.2006.12.658
O'Donnell BF, Barr RM, Black AK, et al. Intravenous immunoglobulin in autoimmune chronic urticaria. Br J Dermatol. 1998;138(1):101-106.
Dawn G, Urcelay M, Ah-Weng A, O'Neill SM, Douglas WS. Effect of high-dose intravenous immunoglobulin in delayed pressure urticaria. Br J Dermatol. 2003;149(4):836-840.
Pereira C, Tavares B, Carrapatoso I, et al. Low-dose intravenous gammaglobulin in the treatment of severe autoimmune urticaria. Eur Ann Allergy Clin Immunol. 2007;39(7):237-242.
Mitzel-Kaoukhov H, Staubach P, Muller-Brenne T. Effect of high-dose intravenous immunoglobulin treatment in therapy-resistant chronic spontaneous urticaria. Ann Allergy Asthma Immunol. 2010;104(3):253-258. doi:10.1016/j.anai.2009.12.007
Bangsgaard N, Skov L, Zachariae C. Treatment of refractory chronic spontaneous urticaria with adalimumab. Acta Derm Venereol. 2017;97(4):524-525. doi:10.2340/00015555-2573
Sand FL, Thomsen SF. TNF-alpha inhibitors for chronic urticaria: experience in 20 patients. J Allergy (Cairo). 2013;2013:1-4. doi:10.1155/2013/130905
Hannuksela M, Kokkonen EL. Ultraviolet light therapy in chronic urticaria. Acta Derm Venereol. 1985;65(5):449-450.
Borzova E, Rutherford A, Konstantinou GN, Leslie KS, Grattan CEH. Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. J Am Acad Dermatol. 2008;59(5):752-757. doi:10.1016/j.jaad.2008.07.016
Engin B, Ozdemir M, Balevi A, Mevlitoglu I. Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled trial. Acta Derm Venereol. 2008;88(3):247-251. doi:10.2340/00015555-0434
Thormann J, Laurberg G, Zachariae H. Oral sodium cromoglycate in chronic urticaria. Allergy. 1980;35(2):139-141.
Laurberg G. Tranexamic acid (Cyklokapron) in chronic urticaria: a double-blind study. Acta Derm Venereol. 1977;57(4):369-370.
Lawlor F, Ormerod AD, Greaves MW. Calcium antagonist in the treatment of symptomatic dermographism. Low-dose and high-dose studies with nifedipine. Dermatologica. 1988;177(5):287-291.
Lawlor F, Black AK, Ward AM, Morris R, Greaves MW. Delayed pressure urticaria, objective evaluation of a variable disease using a dermographometer and assessment of treatment using colchicine. Br J Dermatol. 1989;120(3):403-408.
Dover JS, Black AK, Ward AM, Greaves MW. Delayed pressure urticaria. Clinical features, laboratory investigations, and response to therapy of 44 patients. J Am Acad Dermatol. 1988;18(6):1289-1298.
Asero R, Tedeschi A, Cugno M. Heparin and tranexamic Acid therapy may be effective in treatment-resistant chronic urticaria with elevated d-dimer: a pilot study. Int Arch Allergy Immunol. 2010;152(4):384-389. doi:10.1159/000292947
Novak Z, Yanez A, Kiss I, et al. Safety and tolerability of bilastine 10 mg administered for 12 weeks in children with allergic diseases. Pediatr Allergy Immunol. 2016;27(5):493-498. doi:10.1111/pai.12555
Nayak AS, Berger WE, LaForce CF, et al. Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis. Allergy Asthma Proc. 2017;38(3):222-230. doi:10.2500/aap.2017.38.4050
Gupta S, Khalilieh S, Kantesaria B, Banfield C. Pharmacokinetics of desloratadine in children between 2 and 11 years of age. Br J Clin Pharmacol. 2007;63(5):534-540. doi:10.1111/j.1365-2125.2006.02810.x
Gupta SK, Kantesaria B, Banfield C, Wang Z. Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults. Br J Clin Pharmacol. 2007;64(2):174-184. doi:10.1111/j.1365-2125.2007.02859.x
Meltzer EO, Scheinmann P, Rosado Pinto JE, et al. Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis-a pooled analysis of three studies. Pediatr Allergy Immunol. 2004;15(3):253-260. doi:10.1111/j.1399-3038.2004.00167.x
Pampura AN, Papadopoulos NG, Spicak V, Kurzawa R. Evidence for clinical safety, efficacy, and parent and physician perceptions of levocetirizine for the treatment of children with allergic disease. Int Arch Allergy Immunol. 2011;155(4):367-378. doi:10.1159/000321181
Potter P, Mitha E, Barkai L, et al. Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2-11 years. Pediatr Allergy Immunol. 2016;27(1):55-61. doi:10.1111/pai.12460
Weber-Schoendorfer C, Schaefer C. The safety of cetirizine during pregnancy. A prospective observational cohort study. Reprod Toxicol. 2008;26(1):19-23. doi:10.1016/j.reprotox.2008.05.053
Schwarz EB, Moretti M, Nayak S, Koren G. Risk of hypospadias in offspring of women using loratadine during pregnancy: a systematic review and meta-analysis. Drug Saf 2008;31(9):775-788.
Namazy J, Cabana MD, Scheuerle AE, et al. The Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy. J Allergy Clin Immunol. 2015;135(2):407-412. doi:10.1016/j.jaci.2014.08.025
González-Medina M, Curto-Barredo L, Labrador-Horrillo M, Giménez-Arnau A. Omalizumab use during pregnancy for chronic spontaneous urticaria (CSU): report of two cases. J Eur Acad Dermatol Venereol. 2017;31(5).
Ghazanfar MN, Thomsen SF. Successful and safe treatment of chronic spontaneous urticaria with omalizumab in a woman during two consecutive pregnancies. Case Rep Med 2015;2015:1-3. doi:10.1155/2015/368053
Ensina LF, Cusato-Ensina AP, Camelo-Nunes IC, Solé D. Omalizumab as third-line therapy for urticaria during pregnancy. J Investig Allergol Clin Immunol. 2017;27(5):326-327. doi:10.18176/jiaci.0179
Balshem H, Helfand M, Schünemann HJ, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64(4):401-406. doi:10.1016/j.jclinepi.2010.07.015
Maurer M. Cold Urticaria. In Saini SS, Callen J, eds. UpToDate. Wolters Kluwer Health; 2014.

Auteurs

Torsten Zuberbier (T)

Comprehensive Allergy Centre Charité, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Amir Hamzah Abdul Latiff (AH)

Allergy & Immunology Centre, Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Mohamed Abuzakouk (M)

Department of Allergy and Immunology, Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

Susan Aquilina (S)

Department of Dermatology, Mater Dei Hospital, Msida, Malta.

Riccardo Asero (R)

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (MI), Italy.

Diane Baker (D)

Baker Allergy, Asthma and Dermatology, Portland, Oregon, USA.

Barbara Ballmer-Weber (B)

Clinic for Dermatology and Allergology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Christine Bangert (C)

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Moshe Ben-Shoshan (M)

Division of Allergy, Immunology and Dermatology, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.

Jonathan A Bernstein (JA)

University of Cincinnati Physicians Immunology Research Center, Cincinnati, OH, USA.

Carsten Bindslev-Jensen (C)

Department of Dermatology and Allergy Centre, Odense University Hospital and University of Southern Denmark, Odense, Denmark.

Knut Brockow (K)

Department of Dermatology and Allergy Biederstein, Faculty of Medicine, Technical University Munich, Munich, Germany.

Zenon Brzoza (Z)

Department of Internal Diseases with Division of Allergology, University of Opole, Opole, Poland.

Herberto Jose Chong Neto (HJ)

Division of Allergy and Immunology, Department of Pediatrics, Federal University of Paraná, Curitiba, Brazil.

Martin K Church (MK)

Comprehensive Allergy Centre Charité, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
University of Southampton, Southampton, UK.

Paulo R Criado (PR)

Sociedade Brasileira de Dermatologia (SBD), Centro Universitário FMABC, Alergoskin (UCARE), Santo André, Brazil.

Inna V Danilycheva (IV)

Department of Allergology and Immunotherapy, National Research Center-Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.

Corinna Dressler (C)

Division of Evidence-Based Medicine, Department of Dermatology, Venereology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Luis Felipe Ensina (LF)

Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.

Luz Fonacier (L)

New York University Long Island School of Medicine, New York, New York, USA.

Matthew Gaskins (M)

Division of Evidence-Based Medicine, Department of Dermatology, Venereology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Krisztian Gáspár (K)

Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Aslı Gelincik (A)

Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Ana Giménez-Arnau (A)

Department of Dermatology, Hospital del Mar, Institut Mar d'Investigacions Mèdiques, Universitat Autònoma y Universitat Pompeu Fabra, Barcelona, Spain.

Kiran Godse (K)

Department of Dermatology, D Y Patil University School of Medicine, Navi Mumbai, India.

Margarida Gonçalo (M)

Department of Dermatology, Coimbra University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Clive Grattan (C)

Guy's Hospital, St John's Institute of Dermatology, London, UK.

Martine Grosber (M)

Department of Dermatology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Eckard Hamelmann (E)

Department of Pediatrics, Children's Center Bethel, University Hospital OWL, University Bielefeld, Bielefeld, Germany.

Jacques Hébert (J)

Service d'allergie, Centre Hospitalier Université Laval/Centre Hospitalier Universitaire de Québec, Québec, Quebec, Canada.

Michihiro Hide (M)

Department of Dermatology, Hiroshima University, Hiroshima, Japan.
Department of Dermatology, Hiroshima Citizens Hospital, Hiroshima, Japan.

Allen Kaplan (A)

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.

Alexander Kapp (A)

Department of Dermatology & Allergy, Hannover Medical School (MHH), Hannover, Germany.

Aharon Kessel (A)

Division of Allergy and Clinical Immunology, Bnai Zion Medical Center and the Bruce and Ruth Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Emek Kocatürk (E)

Department of Dermatology, Koç University School of Medicine, Istanbul, Turkey.

Kanokvalai Kulthanan (K)

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Désirée Larenas-Linnemann (D)

Hospital Médica Sur, Mexico City, Mexico.

Antti Lauerma (A)

Department of Dermatology, Allergology and Venereology, Inflammation Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Tabi A Leslie (TA)

Department of Dermatology, Royal Free Hospital, London, UK.

Markus Magerl (M)

Comprehensive Allergy Centre Charité, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology, Berlin, Germany.

Michael Makris (M)

Allergy Unit, 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University General Hospital "Attikon", Athens, Greece.

Raisa Y Meshkova (RY)

Department of Clinical Immunology and Allergology, Smolensk State Medical University, Smolensk, Russia.

Martin Metz (M)

Comprehensive Allergy Centre Charité, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology, Berlin, Germany.

Daniel Micallef (D)

Department of Dermatology, Mater Dei Hospital, Msida, Malta.

Charlotte G Mortz (CG)

Department of Dermatology and Allergy Centre, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital and University of Southern Denmark, Odense, Denmark.

Alexander Nast (A)

Division of Evidence-Based Medicine, Department of Dermatology, Venereology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Hanneke Oude-Elberink (H)

University of Groningen, Groningen, The Netherlands.

Ruby Pawankar (R)

Department of Pediatrics, Nippon Medical School, Tokyo, Japan.

Paolo D Pigatto (PD)

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Hector Ratti Sisa (H)

Primera Cátedra de Clínica Médica, Hospital de Clínicas de la Facultad de Ciencias Médicas-Universidad Nacional de Asunción, Asunción, Paraguay.

María Isabel Rojo Gutiérrez (MI)

Hospital Juárez de México, Mexico City, Mexico.

Sarbjit S Saini (SS)

Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA.

Peter Schmid-Grendelmeier (P)

Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.

Bulent E Sekerel (BE)

Division of Pediatric Allergy and Asthma, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Frank Siebenhaar (F)

Comprehensive Allergy Centre Charité, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology, Berlin, Germany.

Hanna Siiskonen (H)

Department of Pathology, Diagnostic Imaging Centre, Kuopio University Hospital, Kuopio, Finland.

Angele Soria (A)

Department of Dermatology and Allergology, Tenon Hospital, APHP Sorbonne University and Cimi-Paris Inserm 1135, Paris, France.

Petra Staubach-Renz (P)

Department of Dermatology, University Medical Center Mainz, Mainz, Germany.

Luca Stingeni (L)

Dermatology Section, Department of Medicine, University of Perugia, Perugia, Italy.

Gordon Sussman (G)

Division of Allergy and Clinical Immunology, St. Michael's Hospital and University of Toronto, Toronto, Canada.

Andrea Szegedi (A)

Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Simon Francis Thomsen (SF)

Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Zahava Vadasz (Z)

Proteomic and Clinical Flow Cytometry Unit, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Christian Vestergaard (C)

Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.

Bettina Wedi (B)

Department of Dermatology and Allergy, Comprehensive Allergy Center, Hannover Medical School, Hannover, Germany.

Zuotao Zhao (Z)

Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.

Marcus Maurer (M)

Comprehensive Allergy Centre Charité, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology, Berlin, Germany.

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