Rare flavonoids and sesquiterpenoids isolated from the leaves of Goniothalamus gracilipes.
Anti-Bacterial Agents
/ isolation & purification
Antineoplastic Agents, Phytogenic
/ isolation & purification
Cell Line, Tumor
Flavonoids
/ isolation & purification
Goniothalamus
/ chemistry
Humans
Molecular Structure
Phytochemicals
/ isolation & purification
Plant Leaves
/ chemistry
Sesquiterpenes
/ isolation & purification
Staphylococcus aureus
/ drug effects
Vietnam
Annonaceae
Antimicrobial
Benzopyran-sesquiterpene
Cytotoxic activity
Flavonoid
Goniothalamus gracilipes
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
23
07
2021
revised:
11
09
2021
accepted:
11
09
2021
pubmed:
19
9
2021
medline:
24
12
2021
entrez:
18
9
2021
Statut:
ppublish
Résumé
Three previously undescribed benzopyranyl sesquiterpenes gracilipins BD (1-3) and two flavonoids 5,4'-dihydroxy-6-(2-hydroxybenzyl)-3,7,3'-trimethoxyflavone (4), and 5,4'-dihydroxy-8-(2-hydroxybenzyl)-3,7-dimethoxyflavone (5) were isolated from the leaves of Goniothalamus gracilipes (Annonaceae). Their structures were determined by analyses of MS and 2D NMR data. The absolute configurations of 1 were established by analysis of X-ray diffraction data. Cytotoxic evaluation of the compounds 1-5 against four cancer cell lines (KB, LU-1, HepG-2 and MCF-7) indicated that compound 5 had inhibitory activity against HepG-2 cell line with IC
Identifiants
pubmed: 34536533
pii: S0367-326X(21)00209-4
doi: 10.1016/j.fitote.2021.105034
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antineoplastic Agents, Phytogenic
0
Flavonoids
0
Phytochemicals
0
Sesquiterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105034Informations de copyright
Copyright © 2021. Published by Elsevier B.V.