Informing the study of suicidal thoughts and behaviors in distressed young adults: The use of a machine learning approach to identify neuroimaging, psychiatric, behavioral, and demographic correlates.
Amygdala
Implicit emotion regulation
Machine learning
Suicide prediction
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 11 2021
30 11 2021
Historique:
received:
08
10
2020
revised:
14
08
2021
accepted:
31
08
2021
pubmed:
20
9
2021
medline:
29
3
2022
entrez:
19
9
2021
Statut:
ppublish
Résumé
Young adults are at high risk for suicide, yet there is limited ability to predict suicidal thoughts and behaviors. Machine learning approaches are better able to examine a large number of variables simultaneously to identify combinations of factors associated with suicidal thoughts and behaviors. The current study used LASSO regression to investigate extent to which a number of demographic, psychiatric, behavioral, and functional neuroimaging variables are associated with suicidal thoughts and behaviors during young adulthood. 78 treatment seeking young adults (ages 18-25) completed demographic, psychiatric, behavioral, and suicidality measures. Participants also completed an implicit emotion regulation functional neuroimaging paradigm. Report of recent suicidal thoughts and behaviors served as the dependent variable. Five variables were identified by the LASSO regression: Two were demographic variables (age and level of education), two were psychiatric variables (depression and general psychiatric distress), and one was a neuroimaging variable (left amygdala activity during sad faces). Amygdala function was significantly associated with suicidal thoughts and behaviors above and beyond the other factors. Findings inform the study of suicidal thoughts and behaviors among treatment seeking young adults, and also highlight the importance of investigating neurobiological markers.
Identifiants
pubmed: 34537601
pii: S0925-4927(21)00138-4
doi: 10.1016/j.pscychresns.2021.111386
pmc: PMC8548992
mid: NIHMS1742611
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111386Subventions
Organisme : NIMH NIH HHS
ID : K01 MH109850
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100041
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH100041
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001857
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Références
J Abnorm Child Psychol. 2017 Jul;45(5):971-983
pubmed: 27761783
Mol Psychiatry. 2008 Sep;13(9):829, 833-57
pubmed: 18574483
J Am Acad Child Adolesc Psychiatry. 2019 Feb;58(2):221-231
pubmed: 30738549
Depress Anxiety. 2016 Jun;33(6):460-3
pubmed: 27248363
Psychiatry Res Neuroimaging. 2019 Jul 30;289:1-9
pubmed: 31102892
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:222-227
pubmed: 28445688
J Abnorm Psychol. 2009 Nov;118(4):816-27
pubmed: 19899851
Soc Psychiatry Psychiatr Epidemiol. 2018 Mar;53(3):279-288
pubmed: 29340781
Sci Rep. 2017 Dec;7(1):89
pubmed: 28273888
Psychol Med. 2017 Jun;47(8):1357-1369
pubmed: 27998326
Epidemiol Rev. 2008;30:133-54
pubmed: 18653727
Mol Psychiatry. 2016 Sep;21(9):1194-201
pubmed: 26903272
Br J Psychiatry. 2008 Feb;192(2):98-105
pubmed: 18245022
Front Neuroinform. 2011 Aug 22;5:13
pubmed: 21897815
Bipolar Disord. 2012 Mar;14(2):162-74
pubmed: 22420592
PLoS One. 2014 Feb 11;9(2):e88785
pubmed: 24523939
JAMA. 1993 May 12;269(18):2386-91
pubmed: 8479064
Br J Psychol. 2007 Aug;98(Pt 3):375-87
pubmed: 17705937
Am J Psychiatry. 2017 Jul 1;174(7):667-675
pubmed: 28135845
PLoS One. 2014 Aug 28;9(8):e105169
pubmed: 25166022
J Abnorm Psychol. 2016 Nov;125(8):1185-1200
pubmed: 27618278
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Compr Psychiatry. 2012 Jan;53(1):48-53
pubmed: 21489424
JAMA Psychiatry. 2019 Jan 1;76(1):71-78
pubmed: 30347011
Br J Psychiatry. 2005 Apr;186:297-301
pubmed: 15802685
Psychol Bull. 2017 Feb;143(2):187-232
pubmed: 27841450
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Feb;3(2):125-132
pubmed: 29529407
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
J Child Psychol Psychiatry. 2018 Apr;59(4):460-482
pubmed: 29090457
Arch Clin Neuropsychol. 1996;11(6):513-9
pubmed: 14588456
Compr Psychiatry. 2015 Apr;58:1-10
pubmed: 25595520
J Refract Surg. 1997 Jul-Aug;13(4):388-91
pubmed: 9268940
Front Neurosci. 2012 Aug 06;6:115
pubmed: 22888310
Annu Rev Psychol. 2005;56:287-314
pubmed: 15709937
J Clin Psychol. 1995 Nov;51(6):768-74
pubmed: 8778124
Schizophr Res Cogn. 2017 Nov 08;11:1-5
pubmed: 29159134
Psychol Med. 2013 Oct;43(10):2129-42
pubmed: 23298821
Biol Psychiatry. 2013 Jan 15;73(2):111-8
pubmed: 22784485
Br J Med Psychol. 1959;32(1):50-5
pubmed: 13638508
Mol Psychiatry. 2020 Feb;25(2):408-427
pubmed: 31787757
J Affect Disord. 2020 Mar 15;265:558-566
pubmed: 31787418
Hum Brain Mapp. 2015 Nov;36(11):4346-4360
pubmed: 26252509
Cancer Inform. 2015 May 05;14(Suppl 2):129-38
pubmed: 25983547
Behav Ther. 2008 Jun;39(2):107-16
pubmed: 18502244
JAMA Psychiatry. 2013 Mar;70(3):300-10
pubmed: 23303463
Psychol Med. 2002 Aug;32(6):959-76
pubmed: 12214795