Epstein-Barr virus associated gastric dysplasia: a new rare entity?
Epstein-Barr Virus
Gastric cancer
Gastric dysplasia
Gastroesophageal cancer
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
31
05
2021
accepted:
13
09
2021
revised:
10
09
2021
pubmed:
20
9
2021
medline:
26
4
2022
entrez:
19
9
2021
Statut:
ppublish
Résumé
Epstein-Barr virus (EBV) infection characterizes a portion of gastric adenocarcinomas. However, since there is lack of evidence of EBV presence in pre-neoplastic lesions of gastric mucosa, the etiologic role of EBV in gastric carcinogenesis is still debated. We report an unusual case of an EBV-associated foveolar gastric dysplasia associated with a focus of EBV-positive low-grade tubular adenocarcinoma, arisen in the context of a lymphocytic-like (EBV-positive) gastritis. The present case offers the unique opportunity to determine whether EBV is an early or late event in gastric cancer development and to evaluate its prevalence in patients with gastric dysplasia. To properly address this question, we investigated EBER expression in a large mono-institutional series of gastric and gastro-esophageal cancers (n = 594) and associated precursor lesions (n = 84). All the selected gastric dysplastic lesions (n = 43) resulted EBV negative. In most cases, EBV is present only in gastric and gastroesophageal junction adenocarcinomas, but not in their precursor lesions. However, the reported case indicates that non-conventional EBV-associated dysplasia may represent a novel histopathological entity in the gastric dysplasia scenario and that EBV could play an early direct role in gastric carcinogenesis.
Identifiants
pubmed: 34537878
doi: 10.1007/s00428-021-03206-2
pii: 10.1007/s00428-021-03206-2
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
939-944Subventions
Organisme : Regione del Veneto
ID : NET-2016-02363853
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Correa P (1992) Human gastric carcinogenesis: a multistep and multifactorial process–First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 52(24):6735–6740
Gullo I, Grillo F, Mastracci L et al (2020) Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes. Pathologica 112(3):166–185. https://doi.org/10.32074/1591-951X-166
doi: 10.32074/1591-951X-166
Polk DB, Peek RMJ (2010) Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer 10(6):403–414. https://doi.org/10.1038/nrc2857
doi: 10.1038/nrc2857
Saraggi D, Fassan M, Bornschein J, Farinati F, Realdon S, Valeri N, Rugge M (2016) From Barrett metaplasia to esophageal adenocarcinoma: the molecular background. Histol Histopathol 31(1):25–32
WHO (2019) Classification of Tumours Editorial Board. Digestive system tumours, 5th edn. IARC, Lyon
Cancer Genome Atlas Research Network (2014) Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513(7517):202–9. https://doi.org/10.1038/nature13480
doi: 10.1038/nature13480
Sun K, Jia K, Lv H, et al (2020) EBV-positive gastric cancer: current knowledge and future perspectives. Front Oncol 10:583463. Published 2020 Dec 14. https://doi.org/10.3389/fonc.2020.583463
Coati I, Lotz G, Fanelli GN et al (2019) Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. Br J Cancer 121(3):257–263. https://doi.org/10.1038/s41416-019-0508-4
doi: 10.1038/s41416-019-0508-4
Derks S, Liao X, Chiaravalli AM et al (2016) Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers. Oncotarget 7(22):32925–32932. https://doi.org/10.18632/oncotarget.9076
doi: 10.18632/oncotarget.9076
Xie T, Liu Y, Zhang Z et al (2020) Positive status of Epstein-Barr virus as a biomarker for gastric cancer immunotherapy: a prospective observational study. J Immunother 43(4):139–144. https://doi.org/10.1097/CJI.0000000000000316
doi: 10.1097/CJI.0000000000000316
Kim ST, Cristescu R, Bass AJ et al (2018) Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer. Nat Med 24(9):1449–1458. https://doi.org/10.1038/s41591-018-0101-z
doi: 10.1038/s41591-018-0101-z
Young LS, Yap LF, Murray PG (2016) Epstein-Barr virus: more than 50 years old and still providing surprises. Nat Rev Cancer 16(12):789–802. https://doi.org/10.1038/nrc.2016.92
doi: 10.1038/nrc.2016.92
Zhang W (2014) TCGA divides gastric cancer into four molecular subtypes: implications for individualized therapeutics. Chin J Cancer 33(10):469–470. https://doi.org/10.5732/cjc.014.10117
doi: 10.5732/cjc.014.10117
Genitsch V, Novotny A, Seiler CA, Kröll D, Walch A, Langer R (2015) Epstein-barr virus in gastro-esophageal adenocarcinomas - single center experiences in the context of current literature. Front Oncol 26(5):73. https://doi.org/10.3389/fonc.2015.00073
doi: 10.3389/fonc.2015.00073
Lee J-H, Kim S-H, Han S-H, An J-S, Lee E-S, Y.-S, (2009) Kim, “Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: a meta-analysis.” J Gastroenterol Hepatol 24(3):354–365. https://doi.org/10.1111/j.1440-1746.2009.05775.x
doi: 10.1111/j.1440-1746.2009.05775.x
Beek Van, J,zurHausen A, Klein Kranenbarg E, et al (2004) EBV-positive gastric adenocarcinomas a distinct clinicopathologic entity with a low frequency of lymph node involvement. J Clin Oncol 22(4):664–670. https://doi.org/10.1200/JCO.2004.08.061
doi: 10.1200/JCO.2004.08.061
Koriyama C, Akiba S, Corvalan A et al (2004) Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan. Oncol Rep 12(3):543–547
Ryan JL, Morgan DR, Dominguez RL et al (2009) High levels of Epstein-Barr virus DNA in latently infected gastric adenocarcinoma. Lab Invest 89(1):80–90. https://doi.org/10.1038/labinvest.2008.103
doi: 10.1038/labinvest.2008.103
Vanoli A, Di Sabatino A, Martino M et al (2017) Epstein-Barr virus-positive ileal carcinomas associated with Crohn’s disease. Virchows Arch 471(4):549–552. https://doi.org/10.1007/s00428-017-2209-9
doi: 10.1007/s00428-017-2209-9
Hungermann D, Müller S, Spieker T, Lisner R, Niedobitek G, Herbst H (2001) Low prevalence of latently Epstein-Barr virus-infected cells in chronic gastritis. Microsc Res Tech 53(6):409–413. https://doi.org/10.1002/jemt.1109
doi: 10.1002/jemt.1109
Zur Hausen A, van Rees BP, van Beek J et al (2004) Epstein-Barr virus in gastric carcinomas and gastric stump carcinomas: a late event in gastric carcinogenesis. J Clin Pathol 57(5):487–491. https://doi.org/10.1136/jcp.2003.014068
doi: 10.1136/jcp.2003.014068
Ribeiro J, Malta M, Galaghar A et al (2019) Epstein-Barr virus is absent in gastric superficial neoplastic lesions. Virchows Arch 475(6):757–762. https://doi.org/10.1007/s00428-019-02670-1
doi: 10.1007/s00428-019-02670-1
Hirano A, Yanai H, Shimizu N et al (2003) Evaluation of epstein-barr virus DNA load in gastric mucosa with chronic atrophic gastritis using a real-time quantitative PCR assay. Int J Gastrointest Cancer 34(2–3):87–94. https://doi.org/10.1385/IJGC:34:2-3:087
doi: 10.1385/IJGC:34:2-3:087
Martínez-López JLE, Torres J, Camorlinga-Ponce M, Mantilla A, Leal YA, Fuentes-Pananá EM (2014) Evidence of Epstein-Barr virus association with gastric cancer and non-atrophic gastritis. Viruses 6(1):301–318. https://doi.org/10.3390/v6010301
doi: 10.3390/v6010301
Tanabe H, Mizukami Y, Takei H, Tamamura N, Omura Y, Kobayashi Y, Murakami Y, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Yuzawa S, Hasegawa K, Sumi Y, Tanino M, Fujiya M, Okumura T (2021) Clinicopathological characteristics of Epstein-Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization criteria. J Pathol Clin Res 7(4):397–409. https://doi.org/10.1002/cjp2.209
doi: 10.1002/cjp2.209
Chang MS, Kim HS, Kim CW, Kim YI, Lan Lee B, Kim WH (2002) Epstein-Barr virus, p53 protein, and microsatellite instability in the adenoma-carcinoma sequence of the stomach. Hum Pathol 33(4):415–420. https://doi.org/10.1053/hupa.2002.124718
doi: 10.1053/hupa.2002.124718
Kim L, Kim JM, Hur YS et al (2012) Extended gastritis cystica profunda associated with Epstein-Barr virus-positive dysplasia and carcinoma with lymphoid stroma. Pathol Int 62(5):351–355. https://doi.org/10.1111/j.1440-1827.2012.02806.x
doi: 10.1111/j.1440-1827.2012.02806.x
Choi MG, Jeong JY, Kim KM, Bae JM, Noh JH, Sohn TS, Kim S (2012) Clinical significance of gastritis cystica profunda and its association with Epstein-Barr virus in gastric cancer. Cancer 118(21):5227–5233. https://doi.org/10.1002/cncr.27541
doi: 10.1002/cncr.27541