Nano-in-Micro-Particles Consisting of PLGA Nanoparticles Embedded in Chitosan Microparticles via Spray-Drying Enhances Their Uptake in the Olfactory Mucosa.
chitosan coating
intranasal application
mucosal uptake
nano-in-micro particles
nasal delivery
olfactory transport mechanism
poly lactic-co-glycolic acid particles
spray drying
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
06
2021
accepted:
16
08
2021
entrez:
20
9
2021
pubmed:
21
9
2021
medline:
21
9
2021
Statut:
epublish
Résumé
Intranasal delivery has gained prominence since 1990, when the olfactory mucosa was recognized as the window to the brain and the central nervous system (CNS); this has enabled the direct site specific targeting of neurological diseases for the first time. Intranasal delivery is a promising route because general limitations, such as the blood-brain barrier (BBB) are circumvented. In the treatment of multiple sclerosis (MS) or Alzheimer's disease, for example, future treatment prospects include specialized particles as delivery vehicles. Poly(lactic-
Identifiants
pubmed: 34539414
doi: 10.3389/fphar.2021.732954
pii: 732954
pmc: PMC8440808
doi:
Types de publication
Journal Article
Langues
eng
Pagination
732954Informations de copyright
Copyright © 2021 Spindler, Feuerhake, Ladel, Günday, Flamm, Günday-Türeli, Türeli, Tovar, Schindowski and Gruber-Traub.
Déclaration de conflit d'intérêts
The authors CG, NG-T, and ET are employed by MyBiotech GmbH (66802 Überherrn, Germany). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Eur J Pharm Biopharm. 2018 Dec;133:309-320
pubmed: 30399400
Chest. 2009 Jan;135(1):143-148
pubmed: 19136404
Science. 1990 Sep 21;249(4975):1431-3
pubmed: 1698311
N Engl J Med. 2020 Mar 5;382(10):903-916
pubmed: 31491072
Mol Pharm. 2012 May 7;9(5):1271-9
pubmed: 22462641
J Pharm Sci. 1997 Apr;86(4):509-13
pubmed: 9109057
Pharm Res. 1998 Sep;15(9):1326-31
pubmed: 9755881
Int J Pharm. 1999 May 10;182(1):21-32
pubmed: 10332071
J Comp Neurol. 1990 Jul 1;297(1):1-13
pubmed: 2376627
J Control Release. 2014 Apr 10;179:25-32
pubmed: 24486055
Am Rev Respir Dis. 1970 Jul;102(1):48-52
pubmed: 5427403
Pharmaceutics. 2018 Jul 26;10(3):
pubmed: 30050027
Clin Otolaryngol Allied Sci. 1999 Feb;24(1):67-8
pubmed: 10196653
Pharmaceutics. 2018 Aug 03;10(3):
pubmed: 30081536
Histochem Cell Biol. 2008 Jul;130(1):127-40
pubmed: 18340454
Materials (Basel). 2011 Aug 12;4(8):1399-1416
pubmed: 28824150
Clin Infect Dis. 2020 Jul 28;71(15):793-798
pubmed: 32221523
J Cell Biol. 1991 Dec;115(5):1449-62
pubmed: 1955485
Eur J Pharm Sci. 2016 Sep 20;92:224-34
pubmed: 27185298
Biomaterials. 2004 May;25(10):1771-7
pubmed: 14738840
Pharm Res. 2004 Jan;21(1):43-9
pubmed: 14984256
Acta Biomater. 2011 Dec;7(12):4169-76
pubmed: 21839863
J Control Release. 2012 Jul 20;161(2):505-22
pubmed: 22353619
Am J Physiol Cell Physiol. 2018 Jul 1;315(1):C62-C72
pubmed: 29719169
J Toxicol Environ Health. 1997 Apr 11;50(5):475-506
pubmed: 9140466
Microsc Res Tech. 1992 Oct 1;23(1):49-61
pubmed: 1392071
Semin Immunol. 2008 Apr;20(2):86-100
pubmed: 18162407
Int J Pharm. 2013 Aug 30;453(1):253-84
pubmed: 22820134
J Biomater Appl. 2005 Oct;20(2):157-77
pubmed: 16183675
Int J Pharm. 1999 Sep 30;187(1):53-65
pubmed: 10502613
Drug Deliv Transl Res. 2021 Jan 25;:
pubmed: 33491126
Eur J Pharm Sci. 2012 Aug 30;47(1):6-15
pubmed: 22561106
Eur J Pharm Biopharm. 2008 Sep;70(1):270-8
pubmed: 18492606
J Cell Biol. 1986 Sep;103(3):755-66
pubmed: 3528172
Biomicrofluidics. 2016 Sep 21;10(5):054107
pubmed: 27703593
J Cell Sci. 1994 May;107 ( Pt 5):1347-57
pubmed: 7929640
J Cell Biol. 1988 Apr;106(4):1141-9
pubmed: 2452168
Int J Biol Macromol. 2019 Jun 15;131:167-175
pubmed: 30771390
Am J Physiol. 1992 Feb;262(2 Pt 1):C461-9
pubmed: 1539634
Biomaterials. 2005 May;26(15):2713-22
pubmed: 15585275
J Control Release. 2002 Jan 17;78(1-3):15-24
pubmed: 11772445
Pharm Biotechnol. 2002;13:135-58
pubmed: 11987750
Polymers (Basel). 2019 Feb 02;11(2):
pubmed: 30960228
Eur J Pharm Biopharm. 2018 Jul;128:337-362
pubmed: 29733950
J Histochem Cytochem. 2008 Mar;56(3):267-74
pubmed: 18040078
Int J Pharm. 2009 Sep 8;379(1):146-57
pubmed: 19555750
Histochem Cell Biol. 2008 Aug;130(2):339-61
pubmed: 18523797
Infect Immun. 2001 Jun;69(6):3772-81
pubmed: 11349042
J Control Release. 2012 Jul 20;161(2):496-504
pubmed: 22480607
Adv Drug Deliv Rev. 2005 Nov 3;57(11):1640-65
pubmed: 16182408
Biotechniques. 2016 Jul 01;61(1):33-41
pubmed: 27401672
Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1;307(1):L83-93
pubmed: 24793168
Vaccine. 1994 Jul;12(9):825-32
pubmed: 7526573