Benefits of α-lipoic acid in high-risk pregnancies (Review).
antioxidant
cytokines
immunomodulator
miscarriage
preeclampsia
preterm delivery
α-lipoic acid
Journal
Experimental and therapeutic medicine
ISSN: 1792-1015
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
07
02
2021
accepted:
15
06
2021
entrez:
20
9
2021
pubmed:
21
9
2021
medline:
21
9
2021
Statut:
ppublish
Résumé
α-Lipoic acid (ALA) is a natural molecule that is inconsistently synthesized by the human body and must be provided from exogenous sources, such as food and dietary supplements. Once absorbed, the oxidized form of ALA is transformed into its reduced form, dihydrolipoic acid (DHLA). ALA/DHLA exert direct and indirect antioxidant, anti-inflammatory and fine immunomodulatory effects. ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10). They also inhibit cyclooxygenase 2, thereby decreasing the secretion of prostaglandin E2 and nitrogen oxide, and reducing the risk of miscarriage in the first trimester of pregnancy. In patients at risk of abortion, administration of ALA from the first trimester has shown efficacy by accelerating subchorionic hematoma resorption, with a significant decrease in the accompanying abdominal pain. ALA has been proven to be efficient in maintaining the length of the cervix and keeping it closed following one episode of premature labor. Preeclampsia is a dysfunction caused by abnormal placentation and an excessive maternal inflammatory response, leading to extreme hypoxia in the placental bed and exaggerated oxidative stress, with release of oxygen free radicals. Oxidative stress plays a key role in the development of preeclampsia and intrauterine growth restriction. The hypothesis of antioxidant supplementation may play an essential part in disease prevention and fetal neuroprotection.
Identifiants
pubmed: 34539828
doi: 10.3892/etm.2021.10666
pii: ETM-0-0-10666
pmc: PMC8438679
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1232Informations de copyright
Copyright © 2020, Spandidos Publications.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Clin Mol Allergy. 2016 Jan 21;14:1
pubmed: 26798325
Front Immunol. 2020 Aug 18;11:2025
pubmed: 32973809
Biochim Biophys Acta. 2009 Oct;1790(10):1149-60
pubmed: 19664690
J Neurotrauma. 2000 Oct;17(10):871-90
pubmed: 11063054
Eur Rev Med Pharmacol Sci. 2017 Sep;21(18):4219-4227
pubmed: 29028075
Curr Med Chem. 2004 May;11(9):1135-46
pubmed: 15134511
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1591-6
pubmed: 9037098
Am J Reprod Immunol. 2011 May;65(5):503-11
pubmed: 21029245
Gynecol Obstet Invest. 2010;69(2):122-7
pubmed: 19955811
Pharmacol Rep. 2011;63(4):849-58
pubmed: 22001972
Semin Fetal Neonatal Med. 2006 Oct;11(5):302-8
pubmed: 16682265
Endocrinol Metab Clin North Am. 2006 Mar;35(1):173-91, viii
pubmed: 16310648
PLoS One. 2007 Nov 07;2(11):e1147
pubmed: 18188405
J Obstet Gynaecol Res. 2009 Aug;35(4):609-22
pubmed: 19751318
J Reprod Infertil. 2014 Jul;15(3):147-51
pubmed: 25202672
Neuro Endocrinol Lett. 2004 Dec;25 Suppl 1:35-41
pubmed: 15735584
Semin Fetal Neonatal Med. 2010 Aug;15(4):186-90
pubmed: 20494636
Mediators Inflamm. 2006;2006(4):30485
pubmed: 17047289
Expert Opin Drug Deliv. 2016 Dec;13(12):1695-1708
pubmed: 27292272
J Reprod Immunol. 2010 Mar;84(2):164-70
pubmed: 20106535
Cytogenet Genome Res. 2019;158(4):171-183
pubmed: 31434098
Am J Reprod Immunol. 2010 Jun;63(6):601-10
pubmed: 20455873
Biol Reprod. 2005 Aug;73(2):237-43
pubmed: 15800179
Clin Dev Immunol. 2012;2012:925135
pubmed: 22474485
Placenta. 2000 Sep;21(7):597-602
pubmed: 10985960
Neuroendocrinology. 2012;96(1):13-23
pubmed: 22377769
J Reprod Immunol. 2012 Sep;95(1-2):1-14
pubmed: 22819759
Bull Exp Biol Med. 2003 Sep;136(3):257-60
pubmed: 14666189
Front Immunol. 2014 May 27;5:253
pubmed: 24904596
Gen Pharmacol. 1997 Sep;29(3):315-31
pubmed: 9378235
Obstet Med. 2016 Sep;9(3):113-6
pubmed: 27630746
J Biol Chem. 2001 Oct 19;276(42):38329-36
pubmed: 11477096
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1980S-1985S
pubmed: 21613560
Biochem Biophys Res Commun. 1988 Jan 15;150(1):156-62
pubmed: 3122752
Histochem Cell Biol. 2004 Oct;122(4):369-82
pubmed: 15248072
Biomolecules. 2019 Aug 09;9(8):
pubmed: 31405030
Eur J Immunol. 2015 Apr;45(4):1010-8
pubmed: 25605286
Can J Physiol Pharmacol. 2015 Dec;93(12):1029-41
pubmed: 26235242
Am J Obstet Gynecol. 1993 Dec;169(6):1462-6
pubmed: 8267047
Am J Reprod Immunol. 2003 Mar;49(3):159-68
pubmed: 12797522
Int J Mol Sci. 2018 May 17;19(5):
pubmed: 29772777
Obstet Gynecol. 2010 Aug;116(2 Pt 1):393-401
pubmed: 20664401
Exp Mol Med. 2007 Feb 28;39(1):106-13
pubmed: 17334234
J Matern Fetal Neonatal Med. 2017 Sep;30(18):2243-2249
pubmed: 27718765
Biol Reprod. 2009 Apr;80(4):781-7
pubmed: 19109223
J Pregnancy. 2011;2011:941057
pubmed: 22175022
Gynecol Endocrinol. 2018 Sep;34(9):729-733
pubmed: 29726290
Mol Biol Rep. 2018 Oct;45(5):1565-1568
pubmed: 30054783
J Inherit Metab Dis. 2014 Jul;37(4):553-63
pubmed: 24777537
Eur Rev Med Pharmacol Sci. 2016 Apr;20(8):1656-63
pubmed: 27160142
J Clin Endocrinol Metab. 2004 Feb;89(2):812-22
pubmed: 14764800
Placenta. 2010 Oct;31(10):886-92
pubmed: 20709392
Am J Reprod Immunol. 2010 Jul 1;64(1):4-11
pubmed: 20219063
Neuropharmacology. 1996 Mar;35(3):369-75
pubmed: 8783212
Eur Rev Med Pharmacol Sci. 2015 Sep;19(18):3426-32
pubmed: 26439038
Am J Obstet Gynecol. 2000 Oct;183(4):874-7
pubmed: 11035329
Antioxidants (Basel). 2020 Apr 25;9(5):
pubmed: 32344912
Int J Clin Pharmacol Ther Toxicol. 1992 Nov;30(11):511-2
pubmed: 1490813
Eur J Immunol. 2008 Dec;38(12):3274-81
pubmed: 19039774