Pseudothrombotic Microangiopathy as a Rare Presentation of Cobalamin Deficiency.
cobalamin deficiency
pancytopenia
pernicious-anemia
pseudo-thrombotic microangiopathy
schistocytes
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
accepted:
14
08
2021
entrez:
20
9
2021
pubmed:
21
9
2021
medline:
21
9
2021
Statut:
epublish
Résumé
The hematological manifestations of cobalamin (vitamin B12) deficiency may range from asymptomatic to life-threatening forms. Pseudothrombotic microangiopathy is a rare but severe presentation, characterized by the presence of hemolysis and schistocytosis, that is completely reversible after vitamin supplementation. We present a challenging diagnostic approach of a 55-year-old man who presented with high hemolytic markers, pancytopenia, and schistocytes on the peripheral smear due to acquired cobalamin deficiency. Subsequent testing revealed positive anti-intrinsic factor and anti-parietal cell antibodies consistent with pernicious anemia. Cobalamin replacement led to the resolution of microangiopathic hemolysis and clinical improvement, thereby confirming the diagnosis. This case highlights the importance of early recognition of this syndrome, which is often misdiagnosed as true microangiopathic hemolytic anemia, confounding appropriate management.
Identifiants
pubmed: 34540418
doi: 10.7759/cureus.17184
pmc: PMC8439408
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e17184Informations de copyright
Copyright © 2021, Pereira Fontes et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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