The Evolutionary Conserved Transmembrane BAX Inhibitor Motif (TMBIM) Containing Protein Family Members 5 and 6 Are Essential for the Development and Survival of

Bi-1 ER stress GHITM GRINA MICS1 calcium lifeguard mitochondria

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2021
Historique:
received: 10 02 2021
accepted: 16 08 2021
entrez: 20 9 2021
pubmed: 21 9 2021
medline: 21 9 2021
Statut: epublish

Résumé

The mammalian Transmembrane BAX Inhibitor Motif (TMBIM) protein family consists of six evolutionarily conserved hydrophobic proteins that affect programmed cell death and the regulation of intracellular calcium levels. The bacterial ortholog BsYetJ is a pH-dependent calcium channel. We here identified seven TMBIM family members in

Identifiants

pubmed: 34540824
doi: 10.3389/fcell.2021.666484
pmc: PMC8446389
doi:

Types de publication

Journal Article

Langues

eng

Pagination

666484

Informations de copyright

Copyright © 2021 Zhang, Buhr, Voigt and Methner.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Li Zhang (L)

University Medical Center, Institute for Molecular Medicine, Johannes Gutenberg University Mainz, Mainz, Germany.

Sebastian Buhr (S)

University Medical Center, Institute for Molecular Medicine, Johannes Gutenberg University Mainz, Mainz, Germany.

Aaron Voigt (A)

Department of Neurology, RWTH Aachen University, Aachen, Germany.
Forschungszentrum Jülich GmbH, JARA-Institute Molecular Neuroscience and Neuroimaging, RWTH Aachen University, Aachen, Germany.

Axel Methner (A)

University Medical Center, Institute for Molecular Medicine, Johannes Gutenberg University Mainz, Mainz, Germany.

Classifications MeSH