The Functions of BET Proteins in Gene Transcription of Biology and Diseases.
bromodomain
bromodomain and extra-terminal domain proteins
cancer
gene transcription
inhibitors
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
06
2021
accepted:
31
07
2021
entrez:
20
9
2021
pubmed:
21
9
2021
medline:
21
9
2021
Statut:
epublish
Résumé
The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology. They are characterized by two tandem bromodomains (BDs) that bind to lysine-acetylated histones and transcription factors, recruit transcription factors and coactivators to target gene sites, and activate RNA polymerase II machinery for transcriptional elongation. Pharmacological inhibition of BET proteins with BD inhibitors has been shown as a promising therapeutic strategy for the treatment of many human diseases including cancer and inflammatory disorders. The recent advances in bromodomain protein biology have further uncovered the complex and versatile functions of BET proteins in the regulation of gene expression in chromatin. In this review article, we highlight our current understanding of BET proteins' functions in mediating protein-protein interactions required for chromatin-templated gene transcription and splicing, chromatin remodeling, DNA replication, and DNA damage repair. We further discuss context-dependent activator
Identifiants
pubmed: 34540900
doi: 10.3389/fmolb.2021.728777
pii: 728777
pmc: PMC8446420
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
728777Subventions
Organisme : NIA NIH HHS
ID : R01 AG072562
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124465
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA239165
Pays : United States
Informations de copyright
Copyright © 2021 Cheung, Kim and Zhou.
Déclaration de conflit d'intérêts
M-MZ is a founder, director, and shareholder of Parkside Scientific, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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