Liver Transplantation in Malignancies: A Comprehensive and Systematic Review on Oncological Outcome.
Imaging
Indication for liver transplantation
Liver malignancies
Liver transplantation
Survival
Journal
Visceral medicine
ISSN: 2297-4725
Titre abrégé: Visc Med
Pays: Switzerland
ID NLM: 101681546
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
02
02
2021
accepted:
20
05
2021
entrez:
20
9
2021
pubmed:
21
9
2021
medline:
21
9
2021
Statut:
ppublish
Résumé
Liver transplantation (LT) is today's standard treatment for both end-stage liver disease and tumors; however, suitable grafts for LT are a scarce resource and outcome after LT is highly dependent on its underlying indication. Thus, patients must be carefully selected to optimize the number of life years gained per graft. This comprehensive and systematic review critically reflects the most recently published oncological outcome data after LT in malignancies based on the preoperative radiological findings. A systematic literature search was conducted to detect preferentially most recent high-volume series or large database analysis on oncological outcomes after LT for both primary liver cancer and liver metastases between January 1, 2019, and November 14, 2020. A comprehensive review on the radiological assessment of the reviewed liver malignancies is included and its preoperative value for an outcome-driven indication reflected. Twenty most recent high-volume or relevant studies including a total number of 2,521 patients were identified including 4, 4, 4, 4, 3, and 1 publications on oncological outcome after LT for hepatocellular carcinoma, cholangiocellular carcinoma, hepatic epitheloid hemangioendothelioma, hepatoblastoma, and both metastatic neuroendocrine tumors and colorectal cancer, respectively. The overall survival is comparable to patients without tumors if patients with malignancies are well selected for LT; however, this is highly dependent on tumor entity, tumor stage, and both neoadjuvant and concomitant treatment. LT is a promising option for better survival in patients with malignant liver tumors in selected patients; however, the indication must be critically discussed prior to LT in every single case in the context of organ shortage.
Identifiants
pubmed: 34540947
doi: 10.1159/000517328
pii: vis-0037-0302
pmc: PMC8406343
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
302-314Informations de copyright
Copyright © 2021 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Transplant Proc. 2020 Jun;52(5):1453-1454
pubmed: 32241636
J Hepatol. 2016 Feb;64(2):433-485
pubmed: 26597456
Liver Transpl. 2004 Apr;10(4):534-40
pubmed: 15048797
Transplant Proc. 2020 Oct;52(8):2507-2511
pubmed: 32307142
J Control Release. 2015 Dec 10;219:248-268
pubmed: 26456750
Transplantation. 2015 Aug;99(8):1613-8
pubmed: 25710611
J Gastrointest Cancer. 2021 Jun;52(2):547-556
pubmed: 32458263
Ann Surg. 2020 Feb;271(2):212-218
pubmed: 31188200
Transplantation. 2016 Jan;100(1):126-33
pubmed: 26050013
Exp Clin Transplant. 2019 Oct;17(5):644-647
pubmed: 28411361
AJR Am J Roentgenol. 2018 Aug;211(2):267-277
pubmed: 29975116
J Clin Oncol. 2005 Feb 20;23(6):1245-52
pubmed: 15718322
BJS Open. 2020 Jun;4(3):467-477
pubmed: 32333527
Genes Dis. 2020 Feb 29;7(3):359-369
pubmed: 32884990
Radiographics. 2011 Jul-Aug;31(4):1017-30
pubmed: 21768236
Hepatology. 2010 Aug;52(2):715-29
pubmed: 20683967
AJR Am J Roentgenol. 2018 Apr;210(4):766-774
pubmed: 29470153
Hepatology. 2001 Jun;33(6):1394-403
pubmed: 11391528
Transplant Proc. 1991 Feb;23(1 Pt 2):1567-8
pubmed: 1989293
Radiology. 2011 Jul;260(1):148-57
pubmed: 21474703
Surg Gynecol Obstet. 1963 Dec;117:659-76
pubmed: 14100514
Radiol Med. 2012 Apr;117(3):354-68
pubmed: 22020424
Transplantation. 2017 Mar;101(3):555-564
pubmed: 28212256
Pediatr Transplant. 2019 May;23(3):e13369
pubmed: 30719825
Hepatology. 2012 Mar;55(3):965-7
pubmed: 22213561
World J Gastroenterol. 2014 May 28;20(20):6180-200
pubmed: 24876739
Lancet Oncol. 2012 Jan;13(1):e11-22
pubmed: 22047762
Gastroenterology. 2012 Jul;143(1):88-98.e3; quiz e14
pubmed: 22504095
Radiology. 2018 Jul;288(1):7-13
pubmed: 29869969
J Am Coll Surg. 2020 Jul;231(1):98-110
pubmed: 32035181
Clin Liver Dis (Hoboken). 2019 Feb 21;13(1):20-25
pubmed: 31168361
Gastroenterology. 2018 Jan;154(1):128-139
pubmed: 28989060
Liver Transpl. 2020 Jun;26(6):785-798
pubmed: 32090444
Ann Surg. 2013 May;257(5):800-6
pubmed: 23360920
Ann Surg Oncol. 2014 Apr;21(4):1323-9
pubmed: 24370906
Transplantation. 2020 Jun;104(6):1187-1192
pubmed: 31577674
J Gastrointest Surg. 2021 Jun;25(6):1487-1493
pubmed: 32632728
Eur J Surg Oncol. 2019 May;45(5):776-781
pubmed: 30401507
J Surg Oncol. 2019 Dec;120(7):1126-1136
pubmed: 31578753
Oncologist. 2010;15 Suppl 4:5-13
pubmed: 21115576
Ann Surg. 1968 Sep;168(3):392-415
pubmed: 4877589
JHEP Rep. 2019 Jul 30;1(5):377-391
pubmed: 32039389
PLoS One. 2019 May 29;14(5):e0216677
pubmed: 31141535
J Gastrointest Surg. 2008 Jan;12(1):110-6
pubmed: 17710508
World J Gastroenterol. 2013 Nov 21;19(43):7515-30
pubmed: 24282343
Dig Dis Sci. 2019 Apr;64(4):934-950
pubmed: 30825108
Int J Surg. 2016 Apr;28 Suppl 1:S156-62
pubmed: 26708853
AJR Am J Roentgenol. 2003 May;180(5):1359-64
pubmed: 12704052
Transplant Proc. 2020 Oct;52(8):2447-2449
pubmed: 32217012
Eur J Surg Oncol. 2012 Aug;38(8):670-6
pubmed: 22652037
Transpl Int. 2018 Dec;31(12):1293-1317
pubmed: 30259574
Eur J Radiol. 2017 Aug;93:295-307
pubmed: 28545872
PLoS One. 2016 Jun 08;11(6):e0156127
pubmed: 27276221
Am J Transplant. 2007 Nov;7(11):2587-96
pubmed: 17868066
Transpl Int. 2019 Apr;32(4):356-368
pubmed: 30556935
Cancer Imaging. 2018 Feb 27;18(1):8
pubmed: 29486800
Lancet. 2005 Oct 8;366(9493):1303-14
pubmed: 16214602
Cancer. 2006 Nov 1;107(9):2108-21
pubmed: 17019735
N Engl J Med. 1996 Mar 14;334(11):693-9
pubmed: 8594428
Surgery. 2019 Feb;165(2):281-285
pubmed: 30471780
Sci Rep. 2019 Nov 1;9(1):15855
pubmed: 31676847
Cancer Imaging. 2016 Aug 15;16(1):21
pubmed: 27526937
AJR Am J Roentgenol. 2010 Jul;195(1):13-28
pubmed: 20566794
World J Gastrointest Oncol. 2020 Mar 15;12(3):248-266
pubmed: 32206176
Ann Surg. 2006 Aug;244(2):254-9
pubmed: 16858188
J Clin Transl Hepatol. 2018 Mar 28;6(1):69-78
pubmed: 29607307
Transplant Proc. 2019 May;51(4):1251-1253
pubmed: 31101208
Liver Transpl. 2006 Aug;12(8):1260-7
pubmed: 16826556
Can J Gastroenterol Hepatol. 2016;2016:6135297
pubmed: 27446853
Hepatology. 2015 Jun;61(6):1968-77
pubmed: 25689978
Ann Surg. 2013 May;257(5):807-15
pubmed: 23532105
Am J Transplant. 2008 Oct;8(10):1982-9
pubmed: 18727702
AJR Am J Roentgenol. 1993 Apr;160(4):793-8
pubmed: 8384403
Ann Transplant. 2019 Aug 20;24:489-498
pubmed: 31427563
Eur Radiol. 2018 Apr;28(4):1529-1539
pubmed: 29079914
Liver Transpl. 2019 Apr;25(4):559-570
pubmed: 30706653
HPB (Oxford). 2014 Jan;16(1):91-8
pubmed: 23600750
J Hepatol. 2007 Oct;47(4):460-6
pubmed: 17697723
J Gastrointest Surg. 2019 Jan;23(1):93-100
pubmed: 30242647
Radiographics. 2000 Jan-Feb;20(1):173-95
pubmed: 10682780
Pediatr Blood Cancer. 2019 Jan;66(1):e27482
pubmed: 30270490
Transplant Proc. 2019 Jul - Aug;51(6):1887-1891
pubmed: 31262438
Biomed Res Int. 2015;2015:497942
pubmed: 26448940
Euroasian J Hepatogastroenterol. 2019 Jul-Dec;9(2):96-101
pubmed: 32117698
Radiographics. 2014 Nov-Dec;34(7):1908-28
pubmed: 25384292
Neuroendocrinology. 2018;106(1):74-88
pubmed: 28728155
J Surg Res. 2019 Oct;242:23-30
pubmed: 31059945
World J Surg Oncol. 2019 Nov 7;17(1):183
pubmed: 31699108