Functional Neural Correlates of a Useful Field of View (UFOV)-Based fMRI Task in Older Adults.
BOLD
UFOV
cognitive aging
fMRI
processing speed
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
20 04 2022
20 04 2022
Historique:
received:
01
06
2021
revised:
10
08
2021
accepted:
11
08
2021
pubmed:
21
9
2021
medline:
10
5
2022
entrez:
20
9
2021
Statut:
ppublish
Résumé
Declines in processing speed performance occur in aging and are a critical marker of functional independence in older adults. Studies suggest that Useful Field of View (UFOV) training may ameliorate cognitive decline. Despite its efficacy, little is known about the neural correlates of this task. Within the current study, 233 healthy older adults completed a UFOV-based task while undergoing functional magnetic resonance imaging (fMRI). During the "stimulus" portion of this task, participants must identify a target in the center of the screen and the location of a target in the periphery, among distractors. During the "probe" portion, participants must decide if the object in the center and the location of the target in the periphery were identical to the "stimulus" screen. Widespread bilateral whole-brain activation was observed when activation patterns of the "probe" contrast were subtracted from the "stimulus" contrast. Conversely, the subtraction of "stimulus" from "probe" was associated with discrete activation patterns consisting of 13 clusters. Additionally, when evaluating the variance associated with task accuracy, specific subregions were identified that may be critical for task performance. Our data elucidate the functional neural correlates of a UFOV-based task, a task used in both cognitive training paradigms and assessment of function.
Identifiants
pubmed: 34541604
pii: 6372106
doi: 10.1093/cercor/bhab332
pmc: PMC9070333
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1993-2012Subventions
Organisme : NIA NIH HHS
ID : R01 AG054077
Pays : United States
Organisme : NIH HHS
ID : S10 OD021726
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG061892
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG020499
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134621
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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