Serum Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein Are Related to the Neurological Impairment and Spinal Edema after Traumatic Spinal Cord Injury.
biomarkers
clinical decision making
diagnostic techniques
spinal cord injuries
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
pubmed:
21
9
2021
medline:
24
3
2022
entrez:
20
9
2021
Statut:
ppublish
Résumé
Neurological examination in the acute phase after spinal cord injury (SCI) is often impossible and severely confounded by pharmacological sedation or concomitant injuries. Therefore, diagnostic biomarkers that objectively characterize severity or the presence of SCI are urgently needed to facilitate clinical decision-making. This study aimed to determine if serum markers of neural origin are related to: 1) presence and severity of SCI, and 2) magnetic resonance imaging (MRI) parameters in the very acute post-injury phase. We performed a secondary analysis of serological parameters, as well as MRI findings in patients with acute SCI (
Identifiants
pubmed: 34541888
doi: 10.1089/neu.2021.0264
doi:
Substances chimiques
GFAP protein, human
0
Glial Fibrillary Acidic Protein
0
Neurofilament Proteins
0
neurofilament protein L
0
ENO2 protein, human
EC 4.2.1.11
Phosphopyruvate Hydratase
EC 4.2.1.11
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM