Autologous stem cell transplantation in a patient with systemic sclerosis-associated interstitial lung disease in Taiwan.
Journal
Asian Pacific journal of allergy and immunology
ISSN: 0125-877X
Titre abrégé: Asian Pac J Allergy Immunol
Pays: Thailand
ID NLM: 8402034
Informations de publication
Date de publication:
05 Sep 2021
05 Sep 2021
Historique:
entrez:
20
9
2021
pubmed:
21
9
2021
medline:
21
9
2021
Statut:
aheadofprint
Résumé
Systemic sclerosis (SSc), characterized by fibrosis of the skin and other organs, is a devastating systemic autoimmune disease. Lung involvement is frequent in SSc and contributes to the high rate of mortality. To describe the first case report of SSc and interstitial lung disease (ILD) receiving autologous hematopoietic stem cell transplantation (ASCT) in Taiwan. Case report. A 51-year-old man presented with rapid skin thickening and shortness of breath. Early progressive SSc-associated ILD was diagnosed. Because his lung function rapidly declined and his skin disease progressed, he received ASCT with satisfactory treatment responses in both skin thickness and lung function. In addition, lung imaging analysis showed remarkable improvements in ILD after treatment. We suggest that ASCT can be considered in selected patients with early, rapidly progressive SSc associated with ILD.
Sections du résumé
BACKGROUND
BACKGROUND
Systemic sclerosis (SSc), characterized by fibrosis of the skin and other organs, is a devastating systemic autoimmune disease. Lung involvement is frequent in SSc and contributes to the high rate of mortality.
OBJECTIVE
OBJECTIVE
To describe the first case report of SSc and interstitial lung disease (ILD) receiving autologous hematopoietic stem cell transplantation (ASCT) in Taiwan.
METHODS
METHODS
Case report.
RESULTS
RESULTS
A 51-year-old man presented with rapid skin thickening and shortness of breath. Early progressive SSc-associated ILD was diagnosed. Because his lung function rapidly declined and his skin disease progressed, he received ASCT with satisfactory treatment responses in both skin thickness and lung function. In addition, lung imaging analysis showed remarkable improvements in ILD after treatment.
CONCLUSIONS
CONCLUSIONS
We suggest that ASCT can be considered in selected patients with early, rapidly progressive SSc associated with ILD.
Identifiants
pubmed: 34542301
doi: 10.12932/AP-080421-1108
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM