TRAP transporter TakP: a key player in the resistance against selenite-induced oxidative stress in Rhodobacter sphaeroides.
Metal resistant microbes
Oxidative stress
Rhodobacter sphaeroides
Selenium
TRAP transporter
Journal
Microbiological research
ISSN: 1618-0623
Titre abrégé: Microbiol Res
Pays: Germany
ID NLM: 9437794
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
25
06
2020
revised:
28
03
2021
accepted:
20
07
2021
pubmed:
21
9
2021
medline:
6
1
2022
entrez:
20
9
2021
Statut:
ppublish
Résumé
Almost one-third of all proteins require metal ions as an essential component in key biological processes and approximately half of all enzymes are associated with one or more metal ions. The naturally occurring selenium is very toxic at higher levels, but few bacteria can reduce it into the less toxic insoluble elemental selenium. Selenium is required for the synthesis of selenocysteine, an essential residue involved in the active sites of various enzymes. The purple non-sulphur bacteria, Rhodobacter sphaeroidesis demonstrated for its selenite reduction capacity. The exact mechanism of selenite toxicity is unknown but it reacts with glutathione to form selenodiglutathione, producing the highly toxic compounds namely, H
Identifiants
pubmed: 34543948
pii: S0944-5013(21)00134-8
doi: 10.1016/j.micres.2021.126828
pii:
doi:
Substances chimiques
Bacterial Proteins
0
NAD
0U46U6E8UK
NADP
53-59-8
Selenious Acid
F6A27P4Q4R
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126828Informations de copyright
Copyright © 2021 Elsevier GmbH. All rights reserved.