INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors.
Antineoplastic Agents
/ chemistry
Breast Neoplasms
/ drug therapy
Cell Line, Tumor
/ drug effects
Cyclin-Dependent Kinase Inhibitor Proteins
/ administration & dosage
Drug Resistance, Neoplasm
Female
Humans
Piperazines
/ chemistry
Protein Kinase Inhibitors
/ chemistry
Pyridines
/ chemistry
Tumor Suppressor Proteins
/ metabolism
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
01
12
2020
revised:
13
07
2021
accepted:
15
09
2021
pubmed:
22
9
2021
medline:
15
3
2022
entrez:
21
9
2021
Statut:
ppublish
Résumé
Cyclin-dependent kinases 4 and 6 (CDK4/6) represent a major therapeutic vulnerability for breast cancer. The kinases are clinically targeted via ATP competitive inhibitors (CDK4/6i); however, drug resistance commonly emerges over time. To understand CDK4/6i resistance, we surveyed over 1,300 breast cancers and identified several genetic alterations (e.g.,
Identifiants
pubmed: 34544752
pii: 2159-8290.CD-20-1726
doi: 10.1158/2159-8290.CD-20-1726
pmc: PMC8831444
mid: NIHMS1743297
doi:
Substances chimiques
Antineoplastic Agents
0
Cyclin-Dependent Kinase Inhibitor Proteins
0
Piperazines
0
Protein Kinase Inhibitors
0
Pyridines
0
Tumor Suppressor Proteins
0
palbociclib
G9ZF61LE7G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
356-371Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA234361
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA247749
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM132386
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA217694
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM121505
Pays : United States
Informations de copyright
©2021 The Authors; Published by the American Association for Cancer Research.
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