Regional variability of melanoma incidence and prevalence in Hungary. Epidemiological impact of ambient UV radiation and socioeconomic factors.
Journal
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
ISSN: 1473-5709
Titre abrégé: Eur J Cancer Prev
Pays: England
ID NLM: 9300837
Informations de publication
Date de publication:
01 07 2022
01 07 2022
Historique:
pubmed:
22
9
2021
medline:
15
6
2022
entrez:
21
9
2021
Statut:
ppublish
Résumé
The incidence of cutaneous melanoma has risen faster than almost any other type of cancer in the last 50 years. Ultraviolet (UV) radiation and genetic susceptibility are the most important risk factors. We aimed to determine the epidemiologic indicators of melanoma in Hungary, a country with an estimated population of 9.8 million and an area of 93 030 km2. Anonymized patient records from the National Health Insurance Fund Management covering the entire population were used to determine the incidence and prevalence of melanoma in the counties of Hungary from 2013 to 2017. Altogether 20 030 melanoma cases were identified for inclusion in this study. The prevalence of melanoma increased over the investigated period and was significantly higher among women than men. The incidence of melanoma stagnated during this period and the incidence rate was the highest among the elderly. Interestingly, the incidence was higher in males in the elderly population, while the incidence was higher in females in the younger (<60 years) population. Geographical variations in ambient UV radiation did not show statistically significant correlation with the regional variability of epidemiologic indicators, probably due to small differences in the number of bright sunshine hours per year between regions. Although Hungary is a relatively small country, we observed regional heterogeneity in socioeconomic factors. Notably, a significant and strong negative correlation was found between single-person household rates and melanoma prevalence. In addition to ambient UV radiation, melanoma incidence and prevalence appear to be related to age, gender and socioeconomic factors.
Sections du résumé
BACKGROUND
The incidence of cutaneous melanoma has risen faster than almost any other type of cancer in the last 50 years. Ultraviolet (UV) radiation and genetic susceptibility are the most important risk factors.
OBJECTIVE
We aimed to determine the epidemiologic indicators of melanoma in Hungary, a country with an estimated population of 9.8 million and an area of 93 030 km2.
METHODS
Anonymized patient records from the National Health Insurance Fund Management covering the entire population were used to determine the incidence and prevalence of melanoma in the counties of Hungary from 2013 to 2017. Altogether 20 030 melanoma cases were identified for inclusion in this study.
RESULTS
The prevalence of melanoma increased over the investigated period and was significantly higher among women than men. The incidence of melanoma stagnated during this period and the incidence rate was the highest among the elderly. Interestingly, the incidence was higher in males in the elderly population, while the incidence was higher in females in the younger (<60 years) population. Geographical variations in ambient UV radiation did not show statistically significant correlation with the regional variability of epidemiologic indicators, probably due to small differences in the number of bright sunshine hours per year between regions. Although Hungary is a relatively small country, we observed regional heterogeneity in socioeconomic factors. Notably, a significant and strong negative correlation was found between single-person household rates and melanoma prevalence.
CONCLUSION
In addition to ambient UV radiation, melanoma incidence and prevalence appear to be related to age, gender and socioeconomic factors.
Identifiants
pubmed: 34545023
doi: 10.1097/CEJ.0000000000000716
pii: 00008469-202207000-00010
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
377-384Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Références
Ambrosini-Spaltro A, Dal Cappello T, Deluca J, Carriere C, Mazzoleni G, Eisendle K (2015). Melanoma incidence and Breslow tumour thickness development in the central Alpine region of South Tyrol from 1998 to 2012: a population-based study. J Eur Acad Dermatol Venereol 29:243–248.
Arnold M, Holterhues C, Hollestein LM, Coebergh JW, Nijsten T, Pukkala E, et al. (2014). Trends in incidence and predictions of cutaneous melanoma across Europe up to 2015. J Eur Acad Dermatol Venereol 28:1170–1178.
Augustin J, Kis A, Sorbe C, Schäfer I, Augustin M (2018). Epidemiology of skin cancer in the German population: impact of socioeconomic and geographic factors. J Eur Acad Dermatol Venereol 32:1906–1913.
Barbaric J, Sekerija M, Agius D, Coza D, Dimitrova N, Demetriou A, et al. (2016). Disparities in melanoma incidence and mortality in South-Eastern Europe: Increasing incidence and divergent mortality patterns. Is progress around the corner? Eur J Cancer 55:47–55.
Bellenghi M, Puglisi R, Pontecorvi G, De Feo A, Carè A, Mattia G (2020). Sex and Gender Disparities in Melanoma. Cancers (Basel) 12:E1819.
Emri G, Paragh G, Tósaki Á, Janka E, Kollár S, Hegedűs C, et al. (2018). Ultraviolet radiation-mediated development of cutaneous melanoma: An update. J Photochem Photobiol B 185:169–175.
Erdmann F, Lortet-Tieulent J, Schüz J, Zeeb H, Greinert R, Breitbart EW, Bray F (2013). International trends in the incidence of malignant melanoma 1953-2008–are recent generations at higher or lower risk? Int J Cancer 132:385–400.
Gilmore S (2017). Melanoma screening: Informing public health policy with quantitative modelling. PLoS One 12:e0182349.
HCSO. Hungarian Central Statistical Office. https://www.ksh.hu/?lang=en .
IARC. International Agency for Research on Cancer. (2020). Lyon. http://www.iarc.who.int . (last accessed 14 May 2021); 2020.
Janka EA, Kékedi K, Várvölgyi T, Gellén E, Kiss B, Remenyik É, Emri G (2019). Increasing melanoma incidence in the elderly in North-East Hungary: is this a more serious problem than we thought? Eur J Cancer Prev 28:544–550.
Jiang AJ, Rambhatla PV, Eide MJ (2015). Socioeconomic and lifestyle factors and melanoma: a systematic review. Br J Dermatol 172:885–915.
Kindem S, Garcías-Ladaria J, Requena C, Guillén C, Oliver V, Nagore E (2015). Survival advantage of women in localized melanoma mainly relies on clinical-pathological differences by sex. A retrospective study of 1,607 patients in Valencia, Spain. Eur J Dermatol 25:247–254.
Kittler H, Binder M, Wolff K, Pehamberger H (2001). A ten-year analysis of demographic trends for cutaneous melanoma: analysis of 2501 cases treated at the University Department of Dermatology in Vienna (1990-1999). Wien Klin Wochenschr 113:321–327.
Kovács P, Pánczél G, Balatoni T, Liszkay G, Gonda X, Bagdy G, Juhasz G (2015). Social support decreases depressogenic effect of low-dose interferon alpha treatment in melanoma patients. J Psychosom Res 78:579–584.
Lasithiotakis KG, Leiter U, Gorkievicz R, Eigentler T, Breuninger H, Metzler G, et al. (2006). The incidence and mortality of cutaneous melanoma in Southern Germany: trends by anatomic site and pathologic characteristics, 1976 to 2003. Cancer 107:1331–1339.
Liu-Smith F, Ziogas A (2020). Age-dependent interaction between sex and geographic ultraviolet index in melanoma risk. J Am Acad Dermatol 82:1102–1108.e3.
Loria D, Abriata MG, Santoro F, Latorre C (2020). Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences. Ecancermedicalscience 14:1017.
Macdonald JB, Dueck AC, Gray RJ, Wasif N, Swanson DL, Sekulic A, Pockaj BA (2011). Malignant melanoma in the elderly: different regional disease and poorer prognosis. J Cancer 2:538–543.
Matsumoto M, Secrest A, Anderson A, Saul MI, Ho J, Kirkwood JM, Ferris LK (2018). Estimating the cost of skin cancer detection by dermatology providers in a large health care system. J Am Acad Dermatol 78:701–709.e1.
Matthews NH, Li WQ, Qureshi AA, Weinstock MA, Cho E (2017). Epidemiology of melanoma. Ward WH, Farma JM, editors. In: Cutaneous melanoma: etiology and therapy [Internet]. Codon Publications. Chapter 1.
McNally RJQ, Basta NO, Errington S, James PW, Norman PD, Craft AW (2014). Socioeconomic patterning in the incidence and survival of children and young people diagnosed with malignant melanoma in northern England. J Invest Dermatol 134:2703–2708.
Moan J, Grigalavicius M, Baturaite Z, Juzeniene A, Dahlback A (2013). North-South gradients of melanomas and non-melanomas: a role of vitamin D? Dermatoendocrinol 5:186–191.
NCR. National Cancer Registry. https://onkol.hu/hungarian-cancer-registry/?lang=en : National Institute of Oncology.
NMS. National Meteorological Service. https://www.met.hu/en/idojaras/ .
Olazagasti Lourido JM, Ma JE, Lohse CM, Brewer JD (2016). Increasing incidence of melanoma in the elderly: an epidemiological study in Olmsted County, Minnesota. Mayo Clin Proc 91:1555–1562.
Olsen CM, Green AC, Pandeya N, Whiteman DC (2019a). Trends in melanoma incidence rates in eight susceptible populations through 2015. J Invest Dermatol 139:1392–1395.
Olsen CM, Pandeya N, Thompson BS, Dusingize JC, Green AC, Neale RE, Whiteman DC; QSkin Study. (2019b). Association between phenotypic characteristics and melanoma in a large prospective cohort study. J Invest Dermatol 139:665–672.
Olsen CM, Pandeya N, Law MH, MacGregor S, Iles MM, Thompson BS, et al.; QSkin Study. (2020). Does polygenic risk influence associations between sun exposure and melanoma? A prospective cohort analysis. Br J Dermatol 183:303–310.
Paulson KG, Gupta D, Kim TS, Veatch JR, Byrd DR, Bhatia S, et al. (2020). Age-specific incidence of melanoma in the United States. JAMA Dermatol 156:57–64.
Péczely G (1998). Éghajlattan. Nemzeti Tankönyvkiadó.
Pinault L, Bushnik T, Fioletov V, Peters CE, King WD, Tjepkema M (2017). The risk of melanoma associated with ambient summer ultraviolet radiation. Health Rep 28:3–11.
Puig S, Marcoval J, Paradelo C, Azon A, Bartralot R, Bel S, et al. (2015). Melanoma incidence increases in the elderly of Catalonia but not in the younger population: effect of prevention or consequence of immigration? Acta Derm Venereol 95:422–426.
Savoye I, Olsen CM, Whiteman DC, Bijon A, Wald L, Dartois L, et al. (2018). Patterns of ultraviolet radiation exposure and skin cancer risk: the E3N-SunExp study. J Epidemiol 28:27–33.
Schoffer O, Schülein S, Arand G, Arnholdt H, Baaske D, Bargou RC, et al. (2016). Tumour stage distribution and survival of malignant melanoma in Germany 2002-2011. BMC Cancer 16:936.
Suppa M, Gandini S, Njimi H, Bulliard JL, Correia O, Duarte AF, et al.; Euromelanoma Working Group. (2019). Association of sunbed use with skin cancer risk factors in Europe: an investigation within the Euromelanoma skin cancer prevention campaign. J Eur Acad Dermatol Venereol 33 (Suppl 2):76–88.
Tripp MK, Watson M, Balk SJ, Swetter SM, Gershenwald JE (2016). State of the science on prevention and screening to reduce melanoma incidence and mortality: the time is now. CA Cancer J Clin 66:460–480.
Vranova J, Arenbergerova M, Arenberger P, Vrana A, Zivcak J, Kolarova H, Rosina J (2014). Malignant melanoma in the Czech Republic: incidence and mortality according to sex, age and disease stage. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 158:438–446.