Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease.

Bipolar Disorder / diagnostic imaging Brain / diagnostic imaging Humans Magnetic Resonance Imaging Prefrontal Cortex / diagnostic imaging Risk Factors

Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
20 09 2021
Historique:
received: 01 07 2021
accepted: 25 08 2021
revised: 06 08 2021
entrez: 21 9 2021
pubmed: 22 9 2021
medline: 12 10 2021
Statut: epublish

Résumé

In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used magnetic resonance imaging (MRI) data from a multicenter study to assess structural gray matter alterations in N = 263 help-seeking individuals from seven study sites. We defined the risk using the EPIbipolar assessment tool as no-risk, low-risk, and high-risk and used a region-of-interest approach (ROI) based on the results of two large-scale multicenter studies of bipolar disorder by the ENIGMA working group. We detected significant differences in the thickness of the left pars opercularis (Cohen's d = 0.47, p = 0.024) between groups. The cortex was significantly thinner in high-risk individuals compared to those in the no-risk group (p = 0.011). We detected no differences in the hippocampal volume. Exploratory analyses revealed no significant differences in other cortical or subcortical regions. The thinner cortex in help-seeking individuals at risk of bipolar disorder is in line with previous findings in patients with the established disorder and corresponds to the region of the highest effect size in the ENIGMA study of cortical alterations. Structural alterations in prefrontal cortex might be a trait marker of bipolar risk. This is the largest structural MRI study of help-seeking individuals at increased risk of bipolar disorder.

Identifiants

DOI: 10.1038/s41398-021-01598-y PMID: 34545071 PMC: PMC8452775
pubmed: 34545071
doi: 10.1038/s41398-021-01598-y
pii: 10.1038/s41398-021-01598-y
pmc: PMC8452775
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

485

Informations de copyright

© 2021. The Author(s).

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Auteurs

Pavol Mikolas (P)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany. pavol.mikolas@uniklinikum-dresden.de.
ORCID: 0000-0002-3974-7115

Kyra Bröckel (K)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.

Christoph Vogelbacher (C)

Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
Department of Psychiatry, University of Marburg, Marburg, Germany.
Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg, Germany.

Dirk K Müller (DK)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Michael Marxen (M)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0001-8870-0041

Christina Berndt (C)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.

Cathrin Sauer (C)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.

Stine Jung (S)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.

Juliane Hilde Fröhner (JH)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0002-8493-6396

Andreas J Fallgatter (AJ)

Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany.

Thomas Ethofer (T)

Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany.
Department for Biomedical Resonance, University of Tübingen, Tübingen, Germany.

Anne Rau (A)

Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany.

Tilo Kircher (T)

Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
Department of Psychiatry, University of Marburg, Marburg, Germany.
Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg, Germany.

Irina Falkenberg (I)

Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
Department of Psychiatry, University of Marburg, Marburg, Germany.
Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg, Germany.
ORCID: 0000-0003-3699-0803

Martin Lambert (M)

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Vivien Kraft (V)

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-5815-1026

Karolina Leopold (K)

Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Vivantes Hospital Am Urban and Vivantes Hospital Im Friedrichshain, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Andreas Bechdolf (A)

Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Vivantes Hospital Am Urban and Vivantes Hospital Im Friedrichshain, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Andreas Reif (A)

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany.
ORCID: 0000-0002-0992-634X

Silke Matura (S)

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany.

Thomas Stamm (T)

Department of Psychiatry and Neurosciences, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Department of Clinical Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.

Felix Bermpohl (F)

Department of Psychiatry and Neurosciences, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Jana Fiebig (J)

Department of Psychiatry and Neurosciences, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Georg Juckel (G)

Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr-University, Bochum, Germany.

Vera Flasbeck (V)

Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr-University, Bochum, Germany.
ORCID: 0000-0001-6405-4567

Christoph U Correll (CU)

Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.
Department of Psychiatry, Northwell Health, The Zucker Hillside Hospital, Glen Oaks, NY, USA.
Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.

Philipp Ritter (P)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0003-4286-5830

Michael Bauer (M)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0002-2666-859X

Andreas Jansen (A)

Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
Department of Psychiatry, University of Marburg, Marburg, Germany.
Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg, Germany.

Andrea Pfennig (A)

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › Individuals at increased risk for development...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Individuals at increased risk for development...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Individuals at increased risk for development...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Individuals at increased risk for development...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › Individuals at increased risk for development...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Individuals at increased risk for development...