The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells.

Microbiology Molecular biology Transcriptomics Virology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
22 Oct 2021
Historique:
received: 06 01 2021
revised: 11 09 2021
accepted: 13 09 2021
pubmed: 22 9 2021
medline: 22 9 2021
entrez: 21 9 2021
Statut: ppublish

Résumé

The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the respiratory tract via spike glycoprotein binding to angiotensin-converting enzyme (ACE2). Circadian rhythms coordinate an organism's response to its environment and can regulate host susceptibility to virus infection. We demonstrate that silencing the circadian regulator

Identifiants

pubmed: 34545347
doi: 10.1016/j.isci.2021.103144
pii: S2589-0042(21)01112-3
pmc: PMC8443536
doi:

Types de publication

Journal Article

Langues

eng

Pagination

103144

Subventions

Organisme : Wellcome Trust
ID : 211050/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 200838/Z/16/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007034
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/COV07001
Pays : United Kingdom

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2021 The Authors.

Déclaration de conflit d'intérêts

The other authors declare no financial interests.

Références

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nat Med. 2014 Aug;20(8):919-26
pubmed: 25064128
FASEB J. 2019 May;33(5):6226-6238
pubmed: 30794439
Cell. 2021 May 13;184(10):2587-2594.e7
pubmed: 33861950
Lancet Microbe. 2020 May;1(1):e14-e23
pubmed: 32835326
J Mol Biol. 2020 May 29;432(12):3515-3524
pubmed: 32304699
Immunity. 2012 Feb 24;36(2):251-61
pubmed: 22342842
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
PLoS One. 2011;6(10):e25858
pubmed: 21998709
BMJ. 2012 Jul 26;345:e4800
pubmed: 22835925
Nat Cell Biol. 2018 Jan;20(1):104-115
pubmed: 29230015
J Clin Invest. 2018 Jun 1;128(6):2281-2296
pubmed: 29533925
Med J Aust. 2020 Jun;212(10):459-462
pubmed: 32237278
Cell Rep. 2021 Apr 20;35(3):109020
pubmed: 33852916
Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10085-90
pubmed: 27528682
Curr Biol. 2006 Jun 6;16(11):1107-15
pubmed: 16753565
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8460-E8468
pubmed: 30127006
Science. 2018 Mar 16;359(6381):
pubmed: 29439024
J Biol Chem. 2005 Aug 26;280(34):30113-9
pubmed: 15983030
Nature. 2021 May;593(7857):142-146
pubmed: 33780970
Nature. 2012 Mar 29;485(7396):62-8
pubmed: 22460951
Mol Cell. 2020 May 21;78(4):779-784.e5
pubmed: 32362314
Science. 2019 Aug 9;365(6453):547-549
pubmed: 31395773
Curr Opin Cell Biol. 2013 Dec;25(6):730-4
pubmed: 23969329
Cell Host Microbe. 2016 Sep 14;20(3):392-405
pubmed: 27631702
Am J Respir Crit Care Med. 2020 Sep 1;202(5):756-759
pubmed: 32663409
J Biol Rhythms. 2021 Feb;36(1):23-34
pubmed: 33480287
Proc Natl Acad Sci U S A. 2018 May 22;115(21):5540-5545
pubmed: 29735673
Cell Rep. 2020 Jul 21;32(3):107915
pubmed: 32649864
Nature. 2020 Sep;585(7825):342-343
pubmed: 32934351
Nature. 2021 Mar;591(7849):293-299
pubmed: 33494095
PLoS Biol. 2005 Oct;3(10):e338
pubmed: 16167846
Sci Rep. 2020 Aug 6;10(1):13271
pubmed: 32764708
Cytokine Growth Factor Rev. 2021 Aug;60:28-45
pubmed: 33992887
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Science. 2020 Oct 23;370(6515):
pubmed: 32972995
Euro Surveill. 2020 Oct;25(42):
pubmed: 33094713
Mol Cell. 2021 Jun 17;81(12):2656-2668.e8
pubmed: 33930332
Cell. 2020 Aug 20;182(4):812-827.e19
pubmed: 32697968
Science. 2012 Aug 31;337(6098):1094-7
pubmed: 22798407
J Virol. 2015 Feb;89(4):1954-64
pubmed: 25428871
J Mol Cell Cardiol. 2003 May;35(5):473-81
pubmed: 12738229
Exp Mol Med. 2020 Sep;52(9):1614-1626
pubmed: 32968200
Genes Dev. 2019 Mar 1;33(5-6):294-309
pubmed: 30804225
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7001-7003
pubmed: 32165541
Int J Mol Sci. 2020 Apr 02;21(7):
pubmed: 32252431
Cell. 2020 Jul 23;182(2):429-446.e14
pubmed: 32526206
Thorax. 2021 Jun;76(6):601-606
pubmed: 33903187
Nat Commun. 2019 Sep 11;10(1):4107
pubmed: 31511530
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7
pubmed: 22184247
EMBO J. 2020 Nov 2;39(21):e106057
pubmed: 32944968
Nat Commun. 2017 Dec 12;8(1):1923
pubmed: 29234010
Endocrinology. 2012 Oct;153(10):4775-83
pubmed: 22893723
J Med Chem. 2013 Jun 13;56(11):4729-37
pubmed: 23656296
Science. 2021 Apr 9;372(6538):
pubmed: 33658326
Pharmacol Res. 2015 Oct;100:288-95
pubmed: 26319800
Noncoding RNA Res. 2020 Dec;5(4):153-166
pubmed: 32923747
Front Vet Sci. 2020 Nov 05;7:586826
pubmed: 33251267
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5761-5771
pubmed: 32132203
Mol Psychiatry. 2020 May 13;:
pubmed: 32404948
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
J Clin Invest. 2021 Jul 15;131(14):
pubmed: 34043590
Gastroenterology. 2020 May;158(7):1948-1966.e1
pubmed: 32061597
PLoS Med. 2011 Dec;8(12):e1001141
pubmed: 22162955
Cell. 2020 Aug 6;182(3):685-712.e19
pubmed: 32645325
Cell. 2021 Jan 7;184(1):92-105.e16
pubmed: 33147445
Trends Endocrinol Metab. 2014 Nov;25(11):586-92
pubmed: 25066191
Nat Rev Mol Cell Biol. 2020 Sep;21(9):494-495
pubmed: 32699357
Elife. 2021 Apr 23;10:
pubmed: 33890572
Trends Endocrinol Metab. 2012 Dec;23(12):619-27
pubmed: 22789990
FASEB J. 2019 Jan;33(1):126-139
pubmed: 29965797
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Nature. 2012 Mar 29;485(7396):123-7
pubmed: 22460952
Nat Rev Immunol. 2018 Jul;18(7):423-437
pubmed: 29662121
Theranostics. 2020 Mar 4;10(9):4168-4182
pubmed: 32226546
Mucosal Immunol. 2018 Jan;11(1):97-111
pubmed: 28401936
J Genet. 2008 Dec;87(5):505-11
pubmed: 19147939
J Infect Dis. 2021 May 28;223(10):1666-1670
pubmed: 33580259
Nat Struct Mol Biol. 2020 Oct;27(10):950-958
pubmed: 32737466
Appl Microbiol Biotechnol. 2021 May;105(10):4005-4015
pubmed: 33950278
Cell Rep. 2021 Mar 23;34(12):108890
pubmed: 33713594
Nat Commun. 2019 Jan 22;10(1):377
pubmed: 30670689
Eur Respir J. 2020 May 14;55(5):
pubmed: 32217650
J Cell Sci. 2011 Feb 1;124(Pt 3):311-20
pubmed: 21242310
J Clin Microbiol. 2004 Jul;42(7):3196-206
pubmed: 15243082
J Biol Chem. 2000 Oct 27;275(43):33238-43
pubmed: 10924499
Cell Metab. 2017 Jan 10;25(1):73-85
pubmed: 27773697
J Clin Invest. 2021 Jul 15;131(14):
pubmed: 34061776
Science. 2020 Sep 4;369(6508):1210-1220
pubmed: 32788292
Cell Metab. 2018 Mar 6;27(3):657-666.e5
pubmed: 29478834
Front Immunol. 2021 May 28;12:656433
pubmed: 34122413
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Immunity. 2012 Aug 24;37(2):290-301
pubmed: 22863835
Cell Metab. 2006 Aug;4(2):163-73
pubmed: 16890544
Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):
pubmed: 33811184
Curr Neurovasc Res. 2020;17(5):531-533
pubmed: 33272180
Nature. 2021 May;593(7858):266-269
pubmed: 33767447
J Gen Virol. 2021 Jan;102(1):
pubmed: 33054904
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12147-12152
pubmed: 31127047
Clin Exp Med. 2020 Nov;20(4):493-506
pubmed: 32720223
Biochem Biophys Res Commun. 2004 Sep 3;321(4):994-1000
pubmed: 15358126
Mol Cell Biol. 1993 May;13(5):3113-21
pubmed: 8474464

Auteurs

Xiaodong Zhuang (X)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Senko Tsukuda (S)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Florian Wrensch (F)

Université de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.

Peter A C Wing (PAC)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.

Mirjam Schilling (M)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

James M Harris (JM)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Helene Borrmann (H)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Sophie B Morgan (SB)

Respiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, Nuffield Department of Medicine, Experimental Medicine, University of Oxford, UK.

Jennifer L Cane (JL)

Respiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, Nuffield Department of Medicine, Experimental Medicine, University of Oxford, UK.

Laurent Mailly (L)

Université de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.

Nazia Thakur (N)

The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, UK.

Carina Conceicao (C)

The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, UK.

Harshmeena Sanghani (H)

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Laura Heydmann (L)

Université de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.

Charlotte Bach (C)

Université de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.

Anna Ashton (A)

Department of Pharmacology, University of Oxford, Oxford, UK.

Steven Walsh (S)

Department of Pharmacology, University of Oxford, Oxford, UK.

Tiong Kit Tan (TK)

MRC Human Immunology Unit, MRC Weatherall Institute, John Radcliffe Hospital, Oxford 17 OX3 9DS, UK.

Lisa Schimanski (L)

Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
MRC Human Immunology Unit, MRC Weatherall Institute, John Radcliffe Hospital, Oxford 17 OX3 9DS, UK.

Kuan-Ying A Huang (KA)

Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University and Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Catherine Schuster (C)

Université de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.

Koichi Watashi (K)

Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Department of Applied Biological Science, Tokyo University of Science, Noda 278-8510, Japan.

Timothy S C Hinks (TSC)

Respiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, Nuffield Department of Medicine, Experimental Medicine, University of Oxford, UK.

Aarti Jagannath (A)

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Sridhar R Vausdevan (SR)

Department of Pharmacology, University of Oxford, Oxford, UK.

Dalan Bailey (D)

The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, UK.

Thomas F Baumert (TF)

Université de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Pole Hépato-digestif, IHU, Hopitaux Universitaires de Strasbourg, Strasbourg, France.

Jane A McKeating (JA)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.

Classifications MeSH