Olfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19.
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
15 Sep 2021
15 Sep 2021
Historique:
pubmed:
22
9
2021
medline:
22
9
2021
entrez:
21
9
2021
Statut:
epublish
Résumé
In this study we conducted RNA sequencing on two brain regions (olfactory bulb and amygdala) from subjects who died from COVID-19 or who died of other causes. We found several-fold more transcriptional changes in the olfactory bulb than in the amygdala, consistent with our own work and that of others indicating that the olfactory bulb may be the initial and most common brain region infected. To some extent our results converge with pseudotime analysis towards common processes shared between the brain regions, possibly induced by the systemic immune reaction following SARS-CoV-2 infection. Changes in amygdala emphasized upregulation of interferon-related neuroinflammation genes, as well as downregulation of synaptic and other neuronal genes, and may represent the substrate of reported acute and subacute COVID-19 neurological effects. Additionally, and only in olfactory bulb, we observed an increase in angiogenesis and platelet activation genes, possibly associated with microvascular damages induced by neuroinflammation. Through coexpression analysis we identified two key genes (
Identifiants
pubmed: 34545375
doi: 10.1101/2021.09.12.21263291
pmc: PMC8452114
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : U01 AG046152
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG030146
Pays : United States
Organisme : NIA NIH HHS
ID : RC2 AG036547
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057473
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046161
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061356
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG032984
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG036042
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048015
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG036836
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States
Références
J Neurol Sci. 2021 Feb 15;421:117308
pubmed: 33497950
Am J Hum Genet. 2017 Nov 2;101(5):768-788
pubmed: 29100089
Physiol Rep. 2021 Feb;9(3):e14726
pubmed: 33523608
Acta Neuropathol. 2020 Jul;140(1):1-6
pubmed: 32449057
Lancet. 2020 Aug 1;396(10247):320-332
pubmed: 32682491
N Engl J Med. 2020 Aug 6;383(6):590-592
pubmed: 32402155
mBio. 2014 Aug 26;5(5):e01476-14
pubmed: 25161189
Lancet Respir Med. 2021 Mar;9(3):251-259
pubmed: 33341155
Front Cell Neurosci. 2021 Mar 09;15:637536
pubmed: 33767612
ACS Chem Neurosci. 2020 May 6;11(9):1200-1203
pubmed: 32283006
Mol Pharmacol. 2020 May;97(5):351-353
pubmed: 32238438
Neurol Clin Pract. 2021 Apr;11(2):e83-e91
pubmed: 33842075
Science. 2020 Nov 13;370(6518):856-860
pubmed: 33082293
Nature. 2016 Jun 22;534(7608):538-43
pubmed: 27337340
Adv Exp Med Biol. 1995;380:79-88
pubmed: 8830550
Virology. 2009 Dec 20;395(2):255-67
pubmed: 19846189
Eur Respir J. 2020 Nov 12;56(5):
pubmed: 33008942
BMC Pediatr. 2020 Sep 9;20(1):429
pubmed: 32907595
Curr Treat Options Neurol. 2020;22(11):37
pubmed: 32994698
Adv Exp Med Biol. 1990;276:637-45
pubmed: 1966460
Lancet Neurol. 2021 Sep;20(9):753-761
pubmed: 34339626
Ann Neurol. 2020 Aug;88(2):423-427
pubmed: 32418288
J Virol. 2000 Oct;74(19):8913-21
pubmed: 10982334
Neuropathol Appl Neurobiol. 2021 Feb;47(1):3-16
pubmed: 32935873
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
AJNR Am J Neuroradiol. 2020 Aug;41(8):1365-1369
pubmed: 32527842
Arch Pathol Lab Med. 2021 Jul 1;145(7):785-796
pubmed: 33720333
Genes (Basel). 2020 Oct 12;11(10):
pubmed: 33053675
Radiology. 2020 Aug;296(2):E119-E120
pubmed: 32228363
J Neurovirol. 1996 Dec;2(6):361-76
pubmed: 8972418
J Virol. 2008 Aug;82(15):7264-75
pubmed: 18495771
Immunity. 2021 Jul 13;54(7):1594-1610.e11
pubmed: 34174183
Clin Chem. 2003 Dec;49(12):2108-9
pubmed: 14633896
J Stroke Cerebrovasc Dis. 2021 Mar;30(3):105549
pubmed: 33341565
J Biol Chem. 2021 Sep;297(3):101041
pubmed: 34358560
Virology. 1992 May;188(1):274-84
pubmed: 1314455
Nature. 2019 Jun;570(7761):332-337
pubmed: 31042697
Brain Pathol. 2020 Nov;30(6):1012-1016
pubmed: 32762083
Cell. 2021 Apr 1;184(7):1836-1857.e22
pubmed: 33713619
Springer Semin Immunopathol. 1995;17(2-3):133-48
pubmed: 8571165
Lancet. 2020 Jun 20;395(10241):e109
pubmed: 32505222
Mod Pathol. 2020 Nov;33(11):2156-2168
pubmed: 32879413
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33433624
J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):889-891
pubmed: 32354768
Histopathology. 2020 Aug;77(2):198-209
pubmed: 32364264
J Exp Med. 2005 Aug 1;202(3):415-24
pubmed: 16043521
Cytokine. 2021 Jul;143:155507
pubmed: 33839002
J Neurovirol. 1997 Feb;3(1):71-5
pubmed: 9147824
Ann Clin Transl Neurol. 2018 Jan 29;5(3):280-296
pubmed: 29560374
Hum Pathol. 2021 Aug;114:110-119
pubmed: 33961839
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Clin Infect Dis. 2005 Oct 15;41(8):1089-96
pubmed: 16163626
Elife. 2021 Mar 30;10:
pubmed: 33781385
Crit Care. 2020 Aug 12;24(1):495
pubmed: 32787909
Neurology. 2020 Oct 6;95(14):e2016-e2027
pubmed: 32546654
JAMA Psychiatry. 2021 Jun 1;78(6):682-683
pubmed: 33769431
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
ACS Chem Neurosci. 2020 Apr 1;11(7):995-998
pubmed: 32167747
J Infect Dis. 2016 Mar 1;213(5):712-22
pubmed: 26486634
J Pathol. 2004 Jun;203(2):622-30
pubmed: 15141376
J Med Virol. 2016 Jan;88(1):1-12
pubmed: 26059175
Eur Heart J Suppl. 2020 Dec 23;22(Suppl Pt t):P25-P28
pubmed: 33390866
Pediatrics. 2004 Jan;113(1 Pt 1):e73-6
pubmed: 14702500
Int J Mol Sci. 2020 Oct 01;21(19):
pubmed: 33019657
J Neurovirol. 2010 Jul;16(4):279-93
pubmed: 20642316
AJNR Am J Neuroradiol. 2020 Jul;41(7):1179-1183
pubmed: 32467191
J Med Virol. 2020 Jul;92(7):699-702
pubmed: 32314810
Lancet Psychiatry. 2020 Oct;7(10):875-882
pubmed: 32593341
Neuropathol Appl Neurobiol. 2021 Apr;47(3):454-459
pubmed: 33249605
Nature. 2012 Sep 20;489(7416):391-399
pubmed: 22996553
Nat Neurosci. 2021 Feb;24(2):168-175
pubmed: 33257876
Cytokine Growth Factor Rev. 2021 Apr;58:1-15
pubmed: 33674185
Ann Intern Med. 2020 Aug 18;173(4):268-277
pubmed: 32374815
BMC Syst Biol. 2007 Nov 21;1:54
pubmed: 18031580
Laryngoscope. 2020 Jul;130(7):1787
pubmed: 32237238
Neurology. 2020 Aug 25;95(8):e1060-e1070
pubmed: 32482845
Brain Commun. 2020 Nov 23;2(2):fcaa205
pubmed: 33376990
Microb Pathog. 1994 May;16(5):349-57
pubmed: 7815918
Crit Care Explor. 2020 Sep 15;2(9):e0218
pubmed: 32984837
Int J Stroke. 2021 Feb;16(2):137-149
pubmed: 33103610
Nat Commun. 2016 Oct 31;7:12849
pubmed: 27796300
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
J Neuroimmunol. 1990 Nov;30(1):31-41
pubmed: 2172304
J Virol. 2011 Jul;85(14):6822-31
pubmed: 21593179
Acta Neuropathol. 2020 Sep;140(3):397-400
pubmed: 32638079
J Infect Dis. 2021 Mar 3;223(5):752-764
pubmed: 33502471
J Virol. 2007 Jan;81(2):813-21
pubmed: 17079315
Forensic Sci Med Pathol. 2021 Sep;17(3):403-410
pubmed: 33963967
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
Lancet Neurol. 2020 Nov;19(11):919-929
pubmed: 33031735
Nat Rev Microbiol. 2006 Feb;4(2):121-32
pubmed: 16415928
Curr Pharm Des. 2007;13(35):3608-21
pubmed: 18220798
Int J Infect Dis. 2020 May;94:55-58
pubmed: 32251791
BMC Infect Dis. 2021 Jun 02;21(1):515
pubmed: 34078305
Radiology. 2020 Nov;297(2):E242-E251
pubmed: 32544034
Am J Med Genet A. 2020 Nov;182(11):2675-2679
pubmed: 32875707
J Neurol. 2020 Nov;267(11):3135-3153
pubmed: 32561990
J Neurol Neurosurg Psychiatry. 2020 Sep;91(9):1004-1006
pubmed: 32651243
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
N Engl J Med. 2021 Feb 4;384(5):481-483
pubmed: 33378608
Infect Dis (Lond). 2020 Aug;52(8):600-602
pubmed: 32552475
Brain Behav Immun. 2020 Jul;87:18-22
pubmed: 32240762
Virchows Arch. 2021 Feb;478(2):343-353
pubmed: 32815036
N Engl J Med. 2016 Aug 4;375(5):497-8
pubmed: 27518687
J Neurol. 2021 Sep;268(9):3105-3115
pubmed: 33547527
Infect Dis (Lond). 2020 Jun;52(6):419-422
pubmed: 32067542
BMC Neurol. 2021 Jan 30;21(1):43
pubmed: 33514335
N Engl J Med. 2020 Sep 3;383(10):989-992
pubmed: 32530583
Rev Neurol (Paris). 2019 Sep - Oct;175(7-8):431-435
pubmed: 31371186
Nat Commun. 2018 Jun 22;9(1):2442
pubmed: 29934517
Brain. 2021 Oct 22;144(9):2696-2708
pubmed: 33856027
Stat Appl Genet Mol Biol. 2005;4:Article17
pubmed: 16646834
Am J Pathol. 2007 Apr;170(4):1136-47
pubmed: 17392154
Acta Neuropathol Commun. 2020 Aug 26;8(1):147
pubmed: 32847628
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Nature. 2020 Aug;584(7821):463-469
pubmed: 32717743
Front Med (Lausanne). 2020 Nov 30;7:598272
pubmed: 33330562
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):2978-2984
pubmed: 34075334
Stroke. 2020 Sep;51(9):e219-e222
pubmed: 32684145
Front Med (Lausanne). 2020 Aug 13;7:521
pubmed: 32903503
Acta Neuropathol. 2020 Oct;140(4):583-586
pubmed: 32851506
Lancet Neurol. 2020 Sep;19(9):767-783
pubmed: 32622375
BMC Neurol. 2021 Mar 30;21(1):138
pubmed: 33784985
Mayo Clin Proc. 2020 Aug;95(8):1621-1631
pubmed: 32753137
Acta Neuropathol. 2016 Feb;131(2):159-184
pubmed: 26659576
JCI Insight. 2020 Sep 3;5(17):
pubmed: 32687484
Neuropathol Appl Neurobiol. 2022 Feb;48(1):e12752
pubmed: 34297438
Neuropathol Appl Neurobiol. 2021 Feb;47(1):17-25
pubmed: 32895961
Nat Immunol. 2015 Dec;16(12):1215-27
pubmed: 26479788
Stroke. 2020 Dec;51(12):3719-3722
pubmed: 33054673
JAMA Otolaryngol Head Neck Surg. 2020 Jul 1;146(7):674-675
pubmed: 32267483
Nature. 2021 Jul;595(7868):565-571
pubmed: 34153974
Sci Transl Med. 2021 Jun 2;13(596):
pubmed: 33941622
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
JAMA Neurol. 2020 Jul 02;:
pubmed: 32614385
Nat Biotechnol. 2015 May;33(5):495-502
pubmed: 25867923