A dynamic microscale mid-throughput fibrosis model to investigate the effects of different ratios of cardiomyocytes and fibroblasts.


Journal

Lab on a chip
ISSN: 1473-0189
Titre abrégé: Lab Chip
Pays: England
ID NLM: 101128948

Informations de publication

Date de publication:
26 10 2021
Historique:
pubmed: 22 9 2021
medline: 3 11 2021
entrez: 21 9 2021
Statut: epublish

Résumé

Cardiac fibrosis is a maladaptive remodeling of the myocardium hallmarked by contraction impairment and excessive extracellular matrix deposition (ECM). The disease progression, nevertheless, remains poorly understood and present treatments are not capable of controlling the scarring process. This is partly due to the absence of physiologically relevant, easily operable, and low-cost

Identifiants

pubmed: 34545378
doi: 10.1039/d1lc00092f
pmc: PMC8547330
doi:

Substances chimiques

Transforming Growth Factor beta1 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4177-4195

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Auteurs

Andrea Mainardi (A)

Departments of Biomedicine and Surgery, University Basel and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Anna.Marsano@usb.ch.
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland.

Francesca Carminati (F)

Departments of Biomedicine and Surgery, University Basel and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Anna.Marsano@usb.ch.
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.

Giovanni Stefano Ugolini (GS)

Departments of Biomedicine and Surgery, University Basel and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Anna.Marsano@usb.ch.

Paola Occhetta (P)

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
BiomimX S.r.l., Via Giovanni Durando 38/A, 20158 Milano, Italy.

Giuseppe Isu (G)

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.

Diana Robles Diaz (D)

Departments of Biomedicine and Surgery, University Basel and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Anna.Marsano@usb.ch.

Gregory Reid (G)

Departments of Biomedicine and Surgery, University Basel and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Anna.Marsano@usb.ch.
Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland.

Roberta Visone (R)

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.

Marco Rasponi (M)

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.

Anna Marsano (A)

Departments of Biomedicine and Surgery, University Basel and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland. Anna.Marsano@usb.ch.

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Classifications MeSH