Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs.
Arterioles
Mouse
Olfactory receptor Olfr78
Prostate-specific G protein-coupled receptor PSGR
Striated muscles
X-gal staining
Journal
Histochemistry and cell biology
ISSN: 1432-119X
Titre abrégé: Histochem Cell Biol
Pays: Germany
ID NLM: 9506663
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
accepted:
03
09
2021
pubmed:
22
9
2021
medline:
9
3
2022
entrez:
21
9
2021
Statut:
ppublish
Résumé
The olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) is a member of the G protein-coupled receptor family mediating olfactory chemosensation, but it is additionally expressed in other tissues. Olfr78 expressed in kidney participates in blood pressure regulation, and in prostate it plays a role in the development of cancer. We here screened many organs/tissues of transgenic mice co-expressing β-galactosidase with Olfr78. X-gal-positive cells were detectable in smooth muscle cells of numerous arterioles of striated muscles (heart ventricles and skeletal muscles of various embryological origin). In addition, in most organs where we found expression of Olfr78 mRNA, X-gal staining was restricted to smooth muscle cells of small blood vessels. The dominant expression of Olfr78 in arteriolar smooth muscle cells supports the concept of an important role in blood pressure regulation and suggests a participation in the fine tuning of blood supply especially of striated muscles. This should be considered when targeting Olfr78 in other contexts such as prostate cancer.
Identifiants
pubmed: 34545457
doi: 10.1007/s00418-021-02032-6
pii: 10.1007/s00418-021-02032-6
pmc: PMC8695541
doi:
Substances chimiques
Olfr78 protein, mouse
0
RNA, Messenger
0
Receptors, Odorant
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
539-553Subventions
Organisme : deutsche forschungsgemeinschaft
ID : SFB-TR84
Organisme : deutsche forschungsgemeinschaft
ID : project A06
Informations de copyright
© 2021. The Author(s).
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