Congenital amusia-pathology of musical disorder.
Congenital amusia
Disconnection syndrome
Hereditary disorder
Pathophysiology
Journal
Journal of applied genetics
ISSN: 2190-3883
Titre abrégé: J Appl Genet
Pays: England
ID NLM: 9514582
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
25
05
2021
accepted:
03
09
2021
revised:
20
08
2021
pubmed:
22
9
2021
medline:
15
1
2022
entrez:
21
9
2021
Statut:
ppublish
Résumé
Amusia also known as tone deafness affects roughly 1.5% population. Congenital amusia appears from birth and lasts over life span. Usually, it is not associated with other diseases. Its link to hearing impairment has been definitively excluded. Neurobiological studies point to asymmetrical processing of musical signals in auditory cortex of left and right brain hemispheres. The finding was supported by discovering microlesions in the right-side gray matter. Because of its connection with asymmetry, amusia has been classified to disconnection syndromes. Alternatively to the neurobiological explanation of amusia background, an attention was turned to the significance of genetic factors. The studies done on relatives and twins indicated familial aggregation of amusia. Molecular genetic investigations linked amusia with deletion of 22q11.2 chromosome region. Until now no specific genes responsible for development of amusia were found.
Identifiants
pubmed: 34545551
doi: 10.1007/s13353-021-00662-z
pii: 10.1007/s13353-021-00662-z
pmc: PMC8755656
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-131Informations de copyright
© 2021. The Author(s).
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