CHARMM-GUI Membrane Builder for Lipid Nanoparticles with Ionizable Cationic Lipids and PEGylated Lipids.
Journal
Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060
Informations de publication
Date de publication:
25 10 2021
25 10 2021
Historique:
pubmed:
22
9
2021
medline:
29
10
2021
entrez:
21
9
2021
Statut:
ppublish
Résumé
A lipid nanoparticle (LNP) formulation is a state-of-the-art delivery system for genetic drugs such as DNA, messenger RNA, and small interfering RNA, which is successfully applied to COVID-19 vaccines and gains tremendous interest in therapeutic applications. Despite its importance, a molecular-level understanding of the LNP structures and dynamics is still lacking, which makes rational LNP design almost impossible. In this work, we present an extension of CHARMM-GUI
Identifiants
pubmed: 34546048
doi: 10.1021/acs.jcim.1c00770
pmc: PMC8545881
mid: NIHMS1742634
doi:
Substances chimiques
COVID-19 Vaccines
0
Lipids
0
RNA, Small Interfering
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5192-5202Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM138472
Pays : United States
Commentaires et corrections
Type : UpdateOf
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