Far from the nuclear crowd: Cytoplasmic lncRNA and their implications in synaptic plasticity and memory.
Long non-coding RNA
Memory
Phase separation
Synaptic plasticity
Translation
Journal
Neurobiology of learning and memory
ISSN: 1095-9564
Titre abrégé: Neurobiol Learn Mem
Pays: United States
ID NLM: 9508166
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
15
04
2021
revised:
20
08
2021
accepted:
10
09
2021
pubmed:
22
9
2021
medline:
12
3
2022
entrez:
21
9
2021
Statut:
ppublish
Résumé
A striking proportion of long non-coding RNAs are expressed specifically in the mammalian brain. Advances in genome-wide sequencing detected widespread diversity in neuronal lncRNAs based on their expression pattern, localization and function. A growing body of literature proposes that localization of lncRNAs is a critical determinant of their function. A rising number of recent findings documented distinct cytoplasmic functions of lncRNAs that are linked to activity-induced control of synaptic plasticity. However, the comprehensive role of cytoplasmic lncRNAs in neuronal functions is less understood. This review surveys our current understanding of lncRNAs that regulate the cytoplasmic life of mRNAs. We discuss the necessity of subcellular localization of lncRNAs in neuronal dendrites and the impact of their compartmentalized positioning on localized translation at the synapse. We have highlighted how lncRNAs modify a functional compartment to meet the demand for input-specific control of synaptic plasticity and memory.
Identifiants
pubmed: 34547434
pii: S1074-7427(21)00144-1
doi: 10.1016/j.nlm.2021.107522
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107522Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.