The GLU-10: a validated ten-point score to identify poorly instructed celiac patients in need of dietary interventions.
Journal
Minerva gastroenterology
ISSN: 2724-5365
Titre abrégé: Minerva Gastroenterol (Torino)
Pays: Italy
ID NLM: 101777280
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
pubmed:
23
9
2021
medline:
23
3
2022
entrez:
22
9
2021
Statut:
ppublish
Résumé
A standard tool to assess patients' knowledge about gluten and the gluten-free diet (GFD) is lacking. We aimed to develop and validate a questionnaire to assess GFD knowledge. A 10-point questionnaire (GLU10) covering different aspects of knowledge about gluten content in food/non-food products and the gluten-free living was developed. To validate this questionnaire, it was administered to adult celiac patients already instructed on gluten and the GFD and non-celiac controls. Patients were prospectively recruited at our Gastroenterology Outpatient Clinic between August 2020 and February 2021. One hundred and six patients (52 celiac patients and 54 controls) participated in the validation phase. Celiac patients scored significantly higher than controls on the GLU10 Questionnaire (median 6 points vs. 2 points, P<0.001). Higher self-reported knowledge of the GFD was related to a higher score (P<0.001). ROC curve confirmed the ability of the GLU10 Questionnaire to discriminate between subjects with good and poor GFD knowledge (AUC=0.94, 95% CI: 0.90-0.98). A score of 5 was identified as the best cut-off (sensitivity 80.8%, specificity 94.4%). On multivariable logistic regression analysis, being a celiac patient (P<0.001) and having a university degree (P=0.04) were associated to a high GLU10 Score (≥5). GLU10 is the first validated questionnaire for assessing knowledge of a GFD in celiac patients and the general population.
Sections du résumé
BACKGROUND
BACKGROUND
A standard tool to assess patients' knowledge about gluten and the gluten-free diet (GFD) is lacking.
METHODS
METHODS
We aimed to develop and validate a questionnaire to assess GFD knowledge. A 10-point questionnaire (GLU10) covering different aspects of knowledge about gluten content in food/non-food products and the gluten-free living was developed. To validate this questionnaire, it was administered to adult celiac patients already instructed on gluten and the GFD and non-celiac controls. Patients were prospectively recruited at our Gastroenterology Outpatient Clinic between August 2020 and February 2021.
RESULTS
RESULTS
One hundred and six patients (52 celiac patients and 54 controls) participated in the validation phase. Celiac patients scored significantly higher than controls on the GLU10 Questionnaire (median 6 points vs. 2 points, P<0.001). Higher self-reported knowledge of the GFD was related to a higher score (P<0.001). ROC curve confirmed the ability of the GLU10 Questionnaire to discriminate between subjects with good and poor GFD knowledge (AUC=0.94, 95% CI: 0.90-0.98). A score of 5 was identified as the best cut-off (sensitivity 80.8%, specificity 94.4%). On multivariable logistic regression analysis, being a celiac patient (P<0.001) and having a university degree (P=0.04) were associated to a high GLU10 Score (≥5).
CONCLUSIONS
CONCLUSIONS
GLU10 is the first validated questionnaire for assessing knowledge of a GFD in celiac patients and the general population.
Identifiants
pubmed: 34547859
pii: S2724-5985.21.03037-0
doi: 10.23736/S2724-5985.21.03037-0
doi:
Substances chimiques
Glutens
8002-80-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM