Involvement of the circular RNA/microRNA/glucose-6-phosphate dehydrogenase axis in the pathological mechanism of hepatocellular carcinoma.
Glucose-6-phosphate dehydrogenase
Hepatocellular carcinoma
Non-coding RNA
Journal
Hepatobiliary & pancreatic diseases international : HBPD INT
ISSN: 1499-3872
Titre abrégé: Hepatobiliary Pancreat Dis Int
Pays: Singapore
ID NLM: 101151457
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
22
02
2021
accepted:
23
08
2021
pubmed:
23
9
2021
medline:
7
4
2022
entrez:
22
9
2021
Statut:
ppublish
Résumé
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide with high mortality. The incidence of HCC is increasing in China. Abnormal activation of glucose-6-phosphate dehydrogenase (G6PD) exists in all malignant tumors, including HCC, and is closely related to the development of HCC. In addition, the differential expression of non-coding RNAs is closely related to the development of HCC. This systematic review focuses on the relationship between G6PD, HCC, and non-coding RNA, which form the basis for the circRNA/miRNA/G6PD axis in HCC. The circular RNA (circRNA)/microRNA (miRNA)/G6PD axis is involved in development of HCC. We proposed that non-coding RNA molecules of the circRNA/miRNA/G6PD axis may be novel biomarkers for the pathological diagnosis, prognosis, and targeted therapy of HCC.
Identifiants
pubmed: 34548225
pii: S1499-3872(21)00170-3
doi: 10.1016/j.hbpd.2021.08.013
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Circular
0
Glucosephosphate Dehydrogenase
EC 1.1.1.49
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
530-534Informations de copyright
Copyright © 2021. Published by Elsevier B.V.