Are Circulating Immune Cells a Determinant of Pancreatic Cancer Risk? A Prospective Study Using Epigenetic Cell Count Measures.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ blood
Case-Control Studies
Causality
Epigenesis, Genetic
/ immunology
Female
Humans
Lymphocyte Count
Male
Middle Aged
Neutrophils
/ metabolism
Pancreatic Neoplasms
/ epidemiology
Prospective Studies
T-Lymphocytes, Regulatory
/ metabolism
Pancreatic Neoplasms
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
09
02
2021
revised:
17
05
2021
accepted:
03
09
2021
pubmed:
23
9
2021
medline:
5
3
2022
entrez:
22
9
2021
Statut:
ppublish
Résumé
Evidence is accumulating that immune cells play a prominent role in pancreatic cancer etiology but prospective investigations are missing. We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 502 pairs of incident pancreatic cancer cases and matched controls. Relative counts of circulating immune cells (neutrophils and lymphocyte sublineages: total CD3 Neither relative counts of immune cell types taken individually, nor mutually adjusted for each other were associated with pancreatic cancer risks. However, in subgroup analyses by strata of lag-time, higher relative counts of Tregs and lower relative counts of CD8 These results might reflect reverse causation, due to higher relative counts of Tregs and lower counts of CD8 We have shown, for the first time, that increased relative counts of regulatory T cells and lower relative counts of CD8
Sections du résumé
BACKGROUND
Evidence is accumulating that immune cells play a prominent role in pancreatic cancer etiology but prospective investigations are missing.
METHODS
We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 502 pairs of incident pancreatic cancer cases and matched controls. Relative counts of circulating immune cells (neutrophils and lymphocyte sublineages: total CD3
RESULTS
Neither relative counts of immune cell types taken individually, nor mutually adjusted for each other were associated with pancreatic cancer risks. However, in subgroup analyses by strata of lag-time, higher relative counts of Tregs and lower relative counts of CD8
CONCLUSIONS
These results might reflect reverse causation, due to higher relative counts of Tregs and lower counts of CD8
IMPACT
We have shown, for the first time, that increased relative counts of regulatory T cells and lower relative counts of CD8
Identifiants
pubmed: 34548327
pii: 1055-9965.EPI-21-0169
doi: 10.1158/1055-9965.EPI-21-0169
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2179-2187Subventions
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M012190/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C570/A16491
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2021 American Association for Cancer Research.
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