The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
Ruminococcus gnavus
antibody
commensal microbe
immunoglobulin-binding protein
superantigen
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
28 09 2021
28 09 2021
Historique:
accepted:
13
07
2021
entrez:
22
9
2021
pubmed:
23
9
2021
medline:
8
10
2021
Statut:
ppublish
Résumé
Microorganisms have coevolved diverse mechanisms to impair host defenses. A major one, superantigens, can result in devastating effects on the immune system. While all known superantigens induce vast immune cell proliferation and come from opportunistic pathogens, recently, proteins with similar broad specificity to antibody variable (V) domain families were identified in a commensal microbiota. These proteins, identified in the human commensal
Identifiants
pubmed: 34548394
pii: 2023898118
doi: 10.1073/pnas.2023898118
pmc: PMC8488583
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Immunoglobulin Heavy Chains
0
Immunoglobulin Variable Region
0
Receptors, Antigen, B-Cell
0
Superantigens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI144094
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM094363
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI038339
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007090
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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