No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis.


Journal

NPJ schizophrenia
ISSN: 2334-265X
Titre abrégé: NPJ Schizophr
Pays: United States
ID NLM: 101657919

Informations de publication

Date de publication:
21 Sep 2021
Historique:
received: 12 04 2021
accepted: 26 08 2021
entrez: 22 9 2021
pubmed: 23 9 2021
medline: 23 9 2021
Statut: epublish

Résumé

Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to examine the relationship between extrastriatal dopamine D2-R availability and cognitive function, using positron emission tomography and the high-affinity D2-R radioligand [

Identifiants

pubmed: 34548499
doi: 10.1038/s41537-021-00176-x
pii: 10.1038/s41537-021-00176-x
pmc: PMC8455597
doi:

Types de publication

Journal Article

Langues

eng

Pagination

46

Subventions

Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2017-00875
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 09114
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 523-2014-3467

Informations de copyright

© 2021. The Author(s).

Références

Am J Psychiatry. 2008 Feb;165(2):214-20
pubmed: 18172018
Eur J Clin Pharmacol. 2014 Feb;70(2):127-34
pubmed: 24145817
Schizophr Bull. 2019 Apr 25;45(3):670-679
pubmed: 29878197
Arch Gen Psychiatry. 1988 Jan;45(1):71-6
pubmed: 2892477
EJNMMI Res. 2020 Jul 8;10(1):77
pubmed: 32642865
J Exp Psychol. 1948 Aug;38(4):404-11
pubmed: 18874598
Schizophr Bull. 1993;19(2):233-59
pubmed: 8322034
JAMA Psychiatry. 2015 Apr;72(4):316-24
pubmed: 25651194
J Int Neuropsychol Soc. 2008 Jan;14(1):110-8
pubmed: 18078537
Front Psychiatry. 2014 Jan 08;4:182
pubmed: 24409157
J Clin Exp Neuropsychol. 2012;34(6):667-77
pubmed: 22439943
Psychiatry Res. 2007 Oct 15;156(1):69-74
pubmed: 17683918
J Clin Psychiatry. 2016 Feb;77 Suppl 2:8-11
pubmed: 26919052
Neurosci Biobehav Rev. 2016 Sep;68:979-1000
pubmed: 27344000
Neuropsychology. 1998 Jul;12(3):426-45
pubmed: 9673998
Am J Psychiatry. 2010 Jul;167(7):828-35
pubmed: 20439390
Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):502-504
pubmed: 31713656
Biol Psychiatry. 1993 Feb 15;33(4):227-35
pubmed: 8097114
Appl Radiat Isot. 2009 Jan;67(1):106-10
pubmed: 19013077
Psychiatr Clin North Am. 2005 Sep;28(3):613-33, 626
pubmed: 16122570
Transl Psychiatry. 2018 Jan 31;8(1):30
pubmed: 29382821
Am J Psychiatry. 1998 Mar;155(3):344-9
pubmed: 9501743
Brain Imaging Behav. 2016 Mar;10(1):1-11
pubmed: 25749917
Am J Psychiatry. 2009 Jun;166(6):675-82
pubmed: 19369319
Neuroimage. 2010 Jun;51(2):918-22
pubmed: 20188195
Nucl Med Biol. 2000 Oct;27(7):661-70
pubmed: 11091109
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Am J Psychiatry. 2009 Aug;166(8):863-74
pubmed: 19411370
Front Psychol. 2015 Mar 03;6:223
pubmed: 25784889
Front Psychol. 2014 Jul 29;5:781
pubmed: 25120503
Am J Psychiatry. 2008 Feb;165(2):203-13
pubmed: 18172019
Schizophr Res. 2014 Sep;158(1-3):156-62
pubmed: 25086658
Int J Neuropsychopharmacol. 2013 Feb;16(1):23-36
pubmed: 22338593
J Psychopharmacol. 2013 Apr;27(4):374-85
pubmed: 23118022
Schizophr Res. 2013 Oct;150(1):42-50
pubmed: 23911259
Int J Neuropsychopharmacol. 2016 Apr 29;19(5):
pubmed: 26819282
Neuroimage. 2012 Mar;60(1):800-7
pubmed: 22227138
Psychopharmacology (Berl). 2018 Aug;235(8):2221-2232
pubmed: 29717334
Schizophr Res. 2018 Feb;192:442-456
pubmed: 28576546
Neuroimage. 2007 Feb 15;34(4):1643-9
pubmed: 17174573
Front Psychiatry. 2018 Dec 05;9:622
pubmed: 30568606
Schizophr Bull. 2009 Jan;35(1):19-31
pubmed: 19042912
J Neurosci. 2008 Nov 12;28(46):12032-8
pubmed: 19005068
Am J Psychiatry. 2000 Apr;157(4):635-7
pubmed: 10739428
Neuroimage. 2004 Jun;22(2):794-803
pubmed: 15193608
Arch Gen Psychiatry. 2012 Aug;69(8):776-86
pubmed: 22474070
Psychol Med. 2019 May;49(7):1138-1147
pubmed: 30058511
Neuroimage. 2008 Apr 15;40(3):1287-95
pubmed: 18296072

Auteurs

Maria Lee (M)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. maria.lee@ki.se.

Helena Fatouros-Bergman (H)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Pontus Plavén-Sigray (P)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Department Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark.

Pauliina Ikonen Victorsson (P)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Carl M Sellgren (CM)

Department of Physiology and Pharmacology, Karolinska Institutet, SE- 171 77, Stockholm, Sweden.

Sophie Erhardt (S)

Department of Physiology and Pharmacology, Karolinska Institutet, SE- 171 77, Stockholm, Sweden.

Lena Flyckt (L)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Lars Farde (L)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Simon Cervenka (S)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden.

Classifications MeSH