Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 09 2021
21 09 2021
Historique:
received:
22
06
2021
accepted:
31
08
2021
entrez:
22
9
2021
pubmed:
23
9
2021
medline:
6
1
2022
Statut:
epublish
Résumé
Perfusion catheters have recently emerged as a novel approach to deliver liquid anti-proliferative agents into flow obstructed arterial segments. The purpose of this study was to determine the impact of luminal delivery pressure on liquid drug penetration into the vessel wall. An ex vivo model using harvested porcine carotid arteries and a two-dimensional computational model were utilized to determine the impact of delivery pressure of liquid therapy into the arterial wall. A pig peripheral injury model determined the impact of intra-luminal delivery pressure on drug retention. Ex vivo results demonstrated that depth of fluid penetration varies from 6.93 ± 1.90% at 0 atm to 27.75 ± 6.61% penetration of the medial layer at 0.4 atm. Computational results had similar outcomes, as penetration varied between 4.4% and 22.84%. The in vivo results demonstrated significant increase in drug delivery to the arterial tissue at 0.4 atm versus 0.1 atm at 1 h (23.43 ± 13.59 ng/mg vs. 2.49 ± 1.81 ng/mg, p = 0.026) and 7 days (0.50 ± 0.39 ng/mg vs. 0.018 ± 0.023 ng/mg, p = 0.0496). The result of this study provides an innovative strategic and technical approach to enable targeted liquid therapy.
Identifiants
pubmed: 34548563
doi: 10.1038/s41598-021-98063-z
pii: 10.1038/s41598-021-98063-z
pmc: PMC8455692
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18676Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB028798
Pays : United States
Organisme : NHLBI NIH HHS
ID : R15 HL127596
Pays : United States
Informations de copyright
© 2021. The Author(s).
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