A Comparison of Demographics, Disease Activity, Disability, and Treatment Among Rheumatoid Arthritis Patients with and without Osteoporosis.
RA OP
biologic
disease activity
disease modifying antirheumatic drugs
effects
osteoporosis
rheumatoid arthritis
Journal
Open access rheumatology : research and reviews
ISSN: 1179-156X
Titre abrégé: Open Access Rheumatol
Pays: New Zealand
ID NLM: 101688698
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
05
2021
accepted:
27
08
2021
entrez:
22
9
2021
pubmed:
23
9
2021
medline:
23
9
2021
Statut:
epublish
Résumé
Osteoporosis (OP) is one of the most common comorbidities associated with rheumatoid arthritis (RA). Literatures reported that the risk for developing OP was strongly associated with duration and severity of RA. We aim to elaborate on the consequences of OP on disease activity and management plan in patients with RA. A retrospective cohort study recruited 408 patients, including those with RA alone and with RA plus OP. The RA disease activity in the patients was assessed using disease activity score in 28 joints (DAS28-CRP). A statistical analysis was performed to compare data between the two groups of patients and determine any significant risk factor associated with the development of OP in RA patients. Of 408 patients who were included in this study, 353 patients (86.5%) had only RA, while 55 patients (13.5%) had RA with OP and showed significant difference ( There was no significant difference in disease activity at both groups of patients. However, RA with OP group had longer duration of RA, were more frequently treated with steroids, and had greater disability. We recommend physicians focus on controlling RA disease activity, early screening for and treating of OP.
Identifiants
pubmed: 34548823
doi: 10.2147/OARRR.S318810
pii: 318810
pmc: PMC8449680
doi:
Types de publication
Journal Article
Langues
eng
Pagination
275-283Informations de copyright
© 2021 Abdulkhaliq et al.
Déclaration de conflit d'intérêts
This study was funded by the Alzaidi Chair of Research Chair in Rheumatic Disease, Umm Al Qura University, Makkah, Saudi Arabia. Rheumatoid arthritis Saudi Database (RASD) is a registry designed and funded by Alzaidi Chair and partially funded by Pfizer pharmaceutical. The authors report no other conflicts of interest in this work.
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