Healthy Aging Biomarkers: The INSPIRE's Contribution.
Biomarkers
dependence
frailty
healthy aging
Journal
The Journal of frailty & aging
ISSN: 2260-1341
Titre abrégé: J Frailty Aging
Pays: France
ID NLM: 101604797
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
22
9
2021
pubmed:
23
9
2021
medline:
24
9
2021
Statut:
ppublish
Résumé
The find solutions for optimizing healthy aging and increase health span is one of the main challenges for our society. A novel healthcare model based on integration and a shift on research and care towards the maintenance of optimal functional levels are now seen as priorities by the WHO. To address this issue, an integrative global strategy mixing longitudinal and experimental cohorts with an innovative transverse understanding of physiological functioning is missing. While the current approach to the biology of aging is mainly focused on parenchymal cells, we propose that age-related loss of function is largely determined by three elements which constitute the general ground supporting the different specific parenchyma: i.e. the stroma, the immune system and metabolism. Such strategy that is implemented in INSPIRE projects can strongly help to find a composite biomarker capable of predicting changes in capacity across the life course with thresholds signalling frailty and care dependence.
Identifiants
pubmed: 34549244
doi: 10.14283/jfa.2021.15
pmc: PMC8081649
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
313-319Déclaration de conflit d'intérêts
All authors of the paper “The INSPIRE research initiative: a program for GeroScience and healthy aging research going from animal models to humans and the healthcare system” declare no Conflicts of Interest related to this manuscript.
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