The Protective Effects of Live and Pasteurized Akkermansia muciniphila and Its Extracellular Vesicles against HFD/CCl4-Induced Liver Injury.

Akkermansia / chemistry Animals Carbon Tetrachloride / adverse effects Diet, High-Fat Extracellular Vesicles / chemistry Feces / microbiology Hepatic Stellate Cells Humans Liver / drug effects Liver Cirrhosis / chemically induced Male Mice Mice, Inbred C57BL Probiotics / administration & dosage Protective Agents / administration & dosage
Akkermansia muciniphila extracellular vesicles hepatic stellate cells intestinal bacteria liver fibrosis

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
31 10 2021
Historique:
pubmed: 23 9 2021
medline: 27 1 2022
entrez: 22 9 2021
Statut: ppublish

Résumé

Akkermansia muciniphila, as a member of the gut microbiota, has been proposed as a next-generation probiotic. Liver fibrosis is the main determinant of liver dysfunction and mortality in patients with chronic liver disease. In this study, we aimed to determine the beneficial effects of live and pasteurized A. muciniphila and its extracellular vesicles (EVs) on the prevention of liver fibrosis. The response of hepatic stellate cells (HSCs) to live and pasteurized

Identifiants

DOI: 10.1128/Spectrum.00484-21 PMID: 34549998 PMC: PMC8557882
pubmed: 34549998
doi: 10.1128/Spectrum.00484-21
pmc: PMC8557882
doi:

Substances chimiques

Protective Agents 0
Carbon Tetrachloride CL2T97X0V0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0048421

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Auteurs

Shahrbanoo Keshavarz Azizi Raftar (S)

Microbiology Research Center, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.
Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.
Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0002-4492-6716

Fatemeh Ashrafian (F)

Microbiology Research Center, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.
Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.
Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran.

Abbas Yadegar (A)

Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Arezou Lari (A)

Systems Biomedicine Unit, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.

Hamid Reza Moradi (HR)

Department of Basic Sciences, School of Veterinary Medicine, Shiraz Universitygrid.412573.6, Shiraz, Iran.

Arefeh Shahriary (A)

Microbiology Research Center, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.

Masoumeh Azimirad (M)

Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Helia Alavifard (H)

Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Zhaleh Mohsenifar (Z)

Taleghani Hospital, Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mehdi Davari (M)

Microbiology Research Center, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.
Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.

Farzam Vaziri (F)

Microbiology Research Center, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.
Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.

Arfa Moshiri (A)

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Experimental Therapy Unit, Laboratory of Oncology, Giannina Gaslini Children's Hospital, Genoa, Italy.

Seyed Davar Siadat (SD)

Microbiology Research Center, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.
Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Irangrid.420169.8, Tehran, Iran.
ORCID: 0000-0002-6892-5603

Mohammad Reza Zali (MR)

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Verrucomicrobia › Akkermansia (genre) › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Eucaryotes › Animaux › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Tétrachloro-méthane › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Cellules › Cellules étoilées du foie › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Système digestif › Foie › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Probiotiques › The Protective Effects of Live and Pasteurized...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › The Protective Effects of Live and Pasteurized...