Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications.
Arrhythmia
Atrial fibrillation
Cardiometabolic
Gut microbiota
Metabolites
Journal
Cardiovascular research
ISSN: 1755-3245
Titre abrégé: Cardiovasc Res
Pays: England
ID NLM: 0077427
Informations de publication
Date de publication:
24 08 2022
24 08 2022
Historique:
received:
31
03
2021
revised:
08
06
2021
accepted:
25
07
2021
pubmed:
23
9
2021
medline:
27
8
2022
entrez:
22
9
2021
Statut:
ppublish
Résumé
Recent preclinical and observational cohort studies have implicated imbalances in gut microbiota composition as a contributor to atrial fibrillation (AF). The gut microbiota is a complex and dynamic ecosystem containing trillions of microorganisms, which produces bioactive metabolites influencing host health and disease development. In addition to host-specific determinants, lifestyle-related factors such as diet and drugs are important determinants of the gut microbiota composition. In this review, we discuss the evidence suggesting a potential bidirectional association between AF and gut microbiota, identifying gut microbiota-derived metabolites as possible regulators of the AF substrate. We summarize the effect of gut microbiota on the development and progression of AF risk factors, including heart failure, hypertension, obesity, and coronary artery disease. We also discuss the potential anti-arrhythmic effects of pharmacological and diet-induced modifications of gut microbiota composition, which may modulate and prevent the progression to AF. Finally, we highlight important gaps in knowledge and areas requiring future investigation. Although data supporting a direct relationship between gut microbiota and AF are very limited at the present time, emerging preclinical and clinical research dealing with mechanistic interactions between gut microbiota and AF is important as it may lead to new insights into AF pathophysiology and the discovery of novel therapeutic targets for AF.
Identifiants
pubmed: 34550344
pii: 6373888
doi: 10.1093/cvr/cvab292
pmc: PMC9400433
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2415-2427Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL089598
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136389
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131517
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL089598
Pays : United States
Informations de copyright
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.
Déclaration de conflit d'intérêts
Conflict of interest: The authors have no conflict of interest.
Références
Gut. 2020 Aug;69(8):1510-1519
pubmed: 32409589
Nutrients. 2019 Nov 22;11(12):
pubmed: 31766592
Nutrients. 2020 May 07;12(5):
pubmed: 32392715
J Interv Card Electrophysiol. 2020 Apr;57(3):371-377
pubmed: 30915593
J Am Heart Assoc. 2015 Oct 09;4(10):e002023
pubmed: 26452986
Acta Pharm Sin B. 2019 Jul;9(4):702-710
pubmed: 31384531
Nature. 2018 Mar 29;555(7698):623-628
pubmed: 29555994
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4410-5
pubmed: 23401498
Cell Host Microbe. 2020 Aug 12;28(2):180-189
pubmed: 32791111
J Nutr. 2020 Feb 1;150(2):249-255
pubmed: 31529091
Cardiovasc Res. 2022 Feb 21;118(3):785-797
pubmed: 33757127
Genome Biol. 2014;15(7):R89
pubmed: 25146375
Nat Rev Cardiol. 2019 Mar;16(3):137-154
pubmed: 30410105
J Am Heart Assoc. 2017 Jun 5;6(6):
pubmed: 28584074
Cell Host Microbe. 2017 Nov 8;22(5):589-599
pubmed: 29120742
Gut. 2015 Nov;64(11):1744-54
pubmed: 25500202
Circulation. 2005 Jun 7;111(22):2881-8
pubmed: 15927979
Front Physiol. 2019 Feb 27;10:171
pubmed: 30890952
Mol Pharm. 2017 Apr 3;14(4):1251-1263
pubmed: 28186768
Nutrients. 2020 Oct 03;12(10):
pubmed: 33022991
Toxins (Basel). 2016 Nov 30;8(12):
pubmed: 27916890
J Cardiovasc Electrophysiol. 2015 Feb;26(2):203-10
pubmed: 25244538
Int Heart J. 2009 May;50(3):353-63
pubmed: 19506339
Nat Commun. 2020 Jan 17;11(1):362
pubmed: 31953381
Nutr Res. 2020 Jun;78:36-41
pubmed: 32464420
FASEB J. 2000 Dec;14(15):2380-2
pubmed: 11024006
Int J Cardiol. 2018 Mar 15;255:92-98
pubmed: 29425570
mSphere. 2020 Mar 18;5(2):
pubmed: 32188747
J Clin Invest. 2019 Jan 2;129(1):373-387
pubmed: 30530985
Biomed Pharmacother. 2018 Jan;97:941-947
pubmed: 29136772
Cell. 2018 Sep 6;174(6):1388-1405.e21
pubmed: 30193112
mBio. 2016 Apr 05;7(2):e02210-15
pubmed: 27048804
Expert Opin Ther Targets. 2020 Dec;24(12):1263-1282
pubmed: 33180654
Mol Med Rep. 2017 Jun;15(6):3767-3774
pubmed: 28440455
Heart Vessels. 2021 Jan;36(1):105-114
pubmed: 32683492
Nat Rev Cardiol. 2018 Jan;15(1):20-32
pubmed: 28836619
Atherosclerosis. 2019 Oct;289:195-200
pubmed: 31303312
Circ Res. 2020 Sep 25;127(8):1036-1055
pubmed: 32762493
Basic Res Cardiol. 2020 Jan 7;115(2):10
pubmed: 31912235
Microbiome. 2017 May 15;5(1):54
pubmed: 28506279
Annu Rev Genomics Hum Genet. 2012;13:151-70
pubmed: 22703178
BMC Biol. 2019 Nov 27;17(1):94
pubmed: 31775890
Oncotarget. 2016 Dec 20;7(51):83951-83963
pubmed: 27924062
Eur Heart J. 2020 Mar 7;41(10):1123-1131
pubmed: 31713590
J Clin Pharmacol. 2013 Oct;53(10):1095-8
pubmed: 23893520
Toxicol Appl Pharmacol. 2014 Jun 1;277(2):138-45
pubmed: 24657338
Am J Med Sci. 2019 Dec;358(6):422-428
pubmed: 31666184
J Infect. 2019 Dec;79(6):471-489
pubmed: 31629863
J Am Coll Cardiol. 2017 Jul 18;70(3):318-327
pubmed: 28705312
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
ESC Heart Fail. 2020 Feb;7(1):188-193
pubmed: 31960610
Cell. 2019 Feb 7;176(4):913-927.e18
pubmed: 30686581
Nat Commun. 2018 Jul 9;9(1):2655
pubmed: 29985401
Can J Cardiol. 2014 Dec;30(12):1700-5
pubmed: 25475471
Cell. 2015 Dec 17;163(7):1585-95
pubmed: 26687352
Cardiovasc Res. 2021 Sep 28;117(11):2291-2293
pubmed: 33822005
Eur Heart J. 2014 Apr;35(14):883-7
pubmed: 24216389
Dis Markers. 2016;2016:7650976
pubmed: 26880856
Int J Mol Med. 2020 Sep;46(3):936-948
pubmed: 32705240
Nutrients. 2018 Oct 01;10(10):
pubmed: 30275434
Diabetes. 2019 Sep;68(9):1747-1755
pubmed: 31167879
Sci Rep. 2018 Nov 16;8(1):16930
pubmed: 30446671
Metabolism. 2021 Apr;117:154712
pubmed: 33497712
JCI Insight. 2020 May 7;5(9):
pubmed: 32302292
Clin Chem. 2021 Jan 8;67(1):288-297
pubmed: 33257943
Diabetes. 2009 Jul;58(7):1509-17
pubmed: 19366864
BMC Genomics. 2020 Jul 30;21(1):526
pubmed: 32731896
Nutrients. 2020 Dec 28;13(1):
pubmed: 33379181
JACC Basic Transl Sci. 2021 Jan 20;6(1):42-52
pubmed: 33532665
Science. 2016 Apr 29;352(6285):565-9
pubmed: 27126040
Hypertension. 2018 Nov;72(5):1141-1150
pubmed: 30354816
Heart Vessels. 2019 Apr;34(4):641-649
pubmed: 30406286
Circulation. 2020 Apr 21;141(16):1295-1306
pubmed: 32134326
Lab Invest. 2019 Mar;99(3):346-357
pubmed: 30068915
Appl Environ Microbiol. 2014 Feb;80(3):1142-9
pubmed: 24296500
Nat Rev Microbiol. 2021 Feb;19(2):77-94
pubmed: 32968241
J Biol Chem. 2015 Feb 27;290(9):5647-60
pubmed: 25550161
J Clin Invest. 2011 Aug;121(8):2955-68
pubmed: 21804195
Science. 2011 Oct 7;334(6052):105-8
pubmed: 21885731
Front Physiol. 2019 Mar 08;10:231
pubmed: 30930793
Europace. 2010 Feb;12(2):160-72
pubmed: 19875395
Molecules. 2021 Feb 22;26(4):
pubmed: 33671813
Life Sci. 2014 Nov 11;117(2):84-92
pubmed: 25301199
Eur Respir J. 2016 Jul;48(1):205-15
pubmed: 27009170
Gut. 2016 May;65(5):740-8
pubmed: 26657899
Am J Epidemiol. 2018 Sep 1;187(9):1916-1922
pubmed: 29800124
Circ Res. 2017 Mar 31;120(7):1183-1196
pubmed: 28360349
N Engl J Med. 2019 Dec 26;381(26):2541-2551
pubmed: 31881139
Nutrition. 2019 Sep;65:50-59
pubmed: 31029922
Eur Heart J. 2021 Feb 1;42(5):373-498
pubmed: 32860505
Physiol Genomics. 2018 May 1;50(5):355-368
pubmed: 29521600
Microbiome. 2020 Mar 14;8(1):36
pubmed: 32169105
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6
pubmed: 20679230
Hypertension. 2021 Aug;78(2):499-511
pubmed: 33966451
Br J Nutr. 2009 Jul;102(2):201-6
pubmed: 19586571
Science. 2017 Aug 25;357(6353):802-806
pubmed: 28839072
Front Physiol. 2017 Mar 21;8:139
pubmed: 28377725
Science. 2013 Jul 19;341(6143):295-8
pubmed: 23869020
Circulation. 2014 Feb 25;129(8):837-47
pubmed: 24345399
ACS Infect Dis. 2020 Oct 9;6(10):2544-2559
pubmed: 32786282
Nutrients. 2017 Oct 30;9(11):
pubmed: 29084143
Nat Rev Microbiol. 2017 Jan;15(1):55-63
pubmed: 27694885
Drug Deliv. 2018 Nov;25(1):1175-1181
pubmed: 29790376
Gigascience. 2019 Jun 1;8(6):
pubmed: 31149718
Obes Rev. 2018 Dec;19(12):1719-1734
pubmed: 30144260
Heart. 2013 Nov;99(22):1685-92
pubmed: 23894089
Protein Cell. 2018 May;9(5):432-445
pubmed: 29705929
J Cardiovasc Pharmacol Ther. 2003 Jun;8 Suppl 1:S5-11
pubmed: 12746747
PLoS Biol. 2016 Aug 19;14(8):e1002533
pubmed: 27541692
PLoS One. 2010 Mar 15;5(3):e9689
pubmed: 20300620
Sci Rep. 2018 Nov 22;8(1):17276
pubmed: 30467393
J Cell Mol Med. 2020 Nov;24(22):13356-13369
pubmed: 33058365
Biochem Pharmacol. 2016 Dec 15;122:72-79
pubmed: 27687643
J Biochem Mol Toxicol. 2019 Feb;33(2):e22246
pubmed: 30370581
J Physiol. 2013 Sep 1;591(17):4273-86
pubmed: 23652593
Circ Genom Precis Med. 2019 Sep;12(9):421-429
pubmed: 31462078
Nat Rev Cardiol. 2017 Feb;14(2):79-87
pubmed: 27905479
Nat Commun. 2016 Jun 30;7:11960
pubmed: 27357947
Circulation. 2018 Nov 13;138(20):2227-2242
pubmed: 29802206
mSystems. 2019 Dec 10;4(6):
pubmed: 31822598
Hepatology. 2011 Oct;54(4):1282-92
pubmed: 21809354
Cardiovasc Res. 2021 Jun 16;117(7):1746-1759
pubmed: 33523143
Eur Heart J. 2013 Jun;34(24):1834-45
pubmed: 22307460
Nat Rev Microbiol. 2018 Jul;16(7):410-422
pubmed: 29795328
Circulation. 2017 Mar 7;135(10):964-977
pubmed: 27927713
Nat Rev Cardiol. 2015 Apr;12(4):230-43
pubmed: 25622848
Nat Med. 2013 May;19(5):576-85
pubmed: 23563705
Int J Cardiol. 2018 Sep 15;267:100-106
pubmed: 29957250
Nature. 2016 Jun 08;534(7606):213-7
pubmed: 27279214
Sci Rep. 2019 Nov 7;9(1):16194
pubmed: 31700098
Nat Commun. 2020 Nov 18;11(1):5886
pubmed: 33208745
Front Physiol. 2019 Jul 09;10:866
pubmed: 31354519
J Am Heart Assoc. 2018 Apr 12;7(8):
pubmed: 29650710
J Hypertens. 2016 Jan;34(1):156-62
pubmed: 26630218