Diffuse vertebral marrow changes at MRI: Multiple myeloma or normal?
Cancer
Hematopoietic marrow hyperplasia
MRI
Multiple myeloma
Journal
Skeletal radiology
ISSN: 1432-2161
Titre abrégé: Skeletal Radiol
Pays: Germany
ID NLM: 7701953
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
24
03
2021
accepted:
27
07
2021
revised:
27
07
2021
pubmed:
23
9
2021
medline:
1
12
2021
entrez:
22
9
2021
Statut:
ppublish
Résumé
Five MRI patterns of marrow involvement (diffuse, focal, combined diffuse and focal, variegated, and normal) are observed in patients with a marrow proliferative disorder including MM. The wide range of marrow involvement patterns in monoclonal plasma cell proliferative disorders mirrors that of their natural histories that can vary from indolent to rapidly lethal. MRI of the axial bone marrow contributes to stage these disorders, but it should not be obtained for disease detection and characterization because of its limited specificity and sensitivity. At MRI, diffuse benign hematopoietic marrow hyperplasia and marrow heterogeneities in elderly patients mimic the diffuse and variegated patterns observed in MM patients. Careful analysis of fat- and fluid-sensitive MR images and quantitative marrow assessment by using MRI and FDG-PET can contribute in differentiating these changes from those associated with neoplastic marrow infiltration, with some residual overlapping findings.
Identifiants
pubmed: 34550397
doi: 10.1007/s00256-021-03886-6
pii: 10.1007/s00256-021-03886-6
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-99Informations de copyright
© 2021. ISS.
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