Endolysosome iron restricts Tat-mediated HIV-1 LTR transactivation by increasing HIV-1 Tat oligomerization and β-catenin expression.
Deferoxamine (DFO)
Endolysosomes
HIV-1-associated neurocognitive disorder (HAND)
Oligomerization
People living with HIV-1 (PLWH)
Tat-mediated HIV-1 LTR transactivation
Transactivator of transcription (Tat)
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
15
04
2021
accepted:
24
08
2021
revised:
06
08
2021
pubmed:
23
9
2021
medline:
17
3
2022
entrez:
22
9
2021
Statut:
ppublish
Résumé
HIV-1 transactivator of transcription (Tat) protein is required for HIV-1 replication, and it has been implicated in the pathogenesis of HIV-1-associated neurocognitive disorder (HAND). HIV-1 Tat can enter cells via receptor-mediated endocytosis where it can reside in endolysosomes; upon its escape from these acidic organelles, HIV-1 Tat can enter the cytosol and nucleus where it activates the HIV-1 LTR promoter. Although it is known that HIV-1 replication is affected by the iron status of people living with HIV-1 (PLWH), very little is known about how iron affects HIV-1 Tat activation of the HIV-1 LTR promoter. Because HIV-1 proteins de-acidify endolysosomes and endolysosome de-acidification affects subcellular levels and actions of iron, we tested the hypothesis that the endolysosome pool of iron is sufficient to affect Tat-induced HIV-1 LTR transactivation. Ferric (Fe
Identifiants
pubmed: 34550543
doi: 10.1007/s13365-021-01016-5
pii: 10.1007/s13365-021-01016-5
pmc: PMC8602775
mid: NIHMS1749333
doi:
Substances chimiques
CTNNB1 protein, human
0
beta Catenin
0
tat Gene Products, Human Immunodeficiency Virus
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
755-773Subventions
Organisme : NINDS NIH HHS
ID : R01 NS065957
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115458
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119000
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100972
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105329
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA032444
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM100329
Pays : United States
Informations de copyright
© 2021. Journal of NeuroVirology, Inc.
Références
Cancer Res. 2011 Dec 15;71(24):7628-39
pubmed: 22009536
J Nutr. 2007 May;137(5):1341-4
pubmed: 17449603
Viruses. 2020 Apr 21;12(4):
pubmed: 32326317
Blood Adv. 2016 Dec 27;1(3):170-183
pubmed: 28203649
Anal Biochem. 2002 May 1;304(1):1-18
pubmed: 11969183
J Virol. 1993 Jan;67(1):277-87
pubmed: 8416373
Antioxidants (Basel). 2014 May 16;3(2):414-38
pubmed: 26784879
Ann Neurol. 2000 Feb;47(2):186-94
pubmed: 10665489
Ann N Y Acad Sci. 2005;1054:141-54
pubmed: 16339660
J Allergy Infect Dis. 2020;1(2):38-48
pubmed: 33196058
Ann N Y Acad Sci. 2005;1054:350-7
pubmed: 16339683
Infect Disord Drug Targets. 2012 Feb;12(1):81-6
pubmed: 22280310
Free Radic Biol Med. 2003 Oct 1;35(7):719-28
pubmed: 14583336
Clin Infect Dis. 2013 Dec;57(11):1626-34
pubmed: 23956164
J Neuroimmune Pharmacol. 2021 Apr 8;:
pubmed: 33834418
Nat Rev Neurol. 2016 Apr;12(4):234-48
pubmed: 26965674
Science. 1988 Apr 1;240(4848):70-3
pubmed: 2832944
Curr Opin HIV AIDS. 2014 Nov;9(6):552-8
pubmed: 25203642
J Neurovirol. 2015 Jun;21(3):276-89
pubmed: 25236812
Cold Spring Harb Perspect Med. 2012 Jun;2(6):a007120
pubmed: 22675662
Front Biosci (Landmark Ed). 2017 Jan 1;22:609-622
pubmed: 27814636
Curr HIV/AIDS Rep. 2015 Jun;12(2):299-303
pubmed: 25869939
Toxicol Sci. 2011 Oct;123(2):523-41
pubmed: 21742779
PLoS One. 2011 Jan 07;6(1):e16148
pubmed: 21249135
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Int J Hematol Oncol Stem Cell Res. 2016 Oct 1;10(4):239-247
pubmed: 27928480
Sci Rep. 2019 Aug 22;9(1):12285
pubmed: 31439883
J Mol Recognit. 2003 Sep-Oct;16(5):265-71
pubmed: 14523939
Front Immunol. 2016 Sep 30;7:397
pubmed: 27746784
Future Virol. 2013 Mar;8(3):301-311
pubmed: 23678366
Cell Discov. 2018 Mar 27;4:14
pubmed: 29619244
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13588-93
pubmed: 23898208
Chem Biol. 2000 Oct;7(10):793-803
pubmed: 11033082
EC Microbiol. 2016;3(6):597-604
pubmed: 28580453
Cold Spring Harb Perspect Biol. 2014 Apr 01;6(4):a016998
pubmed: 24478384
EBioMedicine. 2020 Jan;51:102503
pubmed: 31806564
Antioxid Redox Signal. 2013 Mar 10;18(8):888-98
pubmed: 22909065
J Biol Chem. 2018 May 4;293(18):6721-6735
pubmed: 29567836
Front Pharmacol. 2020 Oct 29;11:595888
pubmed: 33324224
J Natl Med Assoc. 2002 Feb;94(2):73-7
pubmed: 11853049
Am J Pathol. 2011 Oct;179(4):1623-9
pubmed: 21871429
Biochem Pharmacol. 1991 May 1;41(9):1361-3
pubmed: 2018567
Nat Med. 2000 Dec;6(12):1380-7
pubmed: 11100124
Oxid Med Cell Longev. 2016;2016:8910396
pubmed: 27829986
J Virol. 2015 Jan 15;89(2):1024-35
pubmed: 25355898
J Cell Sci. 2002 Feb 1;115(Pt 3):599-607
pubmed: 11861766
Oncotarget. 2016 Sep 27;7(39):64330-64341
pubmed: 27602957
J Virol. 1996 Mar;70(3):1475-80
pubmed: 8627665
BMC Clin Pathol. 2012 Dec 17;12:26
pubmed: 23245266
Neurobiol Aging. 2013 Oct;34(10):2370-8
pubmed: 23673310
J Gen Virol. 2010 Jan;91(Pt 1):1-12
pubmed: 19812265
Biochem Soc Symp. 2005;(72):77-86
pubmed: 15649132
Oncotarget. 2017 Apr 18;8(16):27569-27581
pubmed: 28187438
J Biol Chem. 2001 Feb 2;276(5):3254-61
pubmed: 11024024
J Virol. 2002 Nov;76(22):11440-6
pubmed: 12388705
Curr Opin HIV AIDS. 2014 Nov;9(6):579-84
pubmed: 25275707
Virology. 2008 Nov 10;381(1):1-5
pubmed: 18789806
Ann Neurol. 2009 Aug;66(2):253-8
pubmed: 19743454
J Alzheimers Dis. 2006;9(3 Suppl):277-89
pubmed: 16914867
Oncogene. 2012 Jan 12;31(2):213-25
pubmed: 21666721
Gene Ther. 2007 Dec;14(23):1650-61
pubmed: 17914406
Blood. 2009 Nov 12;114(20):4546-51
pubmed: 19671920
Autophagy. 2016 Sep;12(9):1487-506
pubmed: 27383256
J Gen Virol. 1994 Aug;75 ( Pt 8):1927-34
pubmed: 8046394
Curr HIV/AIDS Rep. 2019 Feb;16(1):96-104
pubmed: 30734905
J Acquir Immune Defic Syndr. 2002 Oct 1;31 Suppl 2:S55-61
pubmed: 12394783
Curr HIV Res. 2014;12(2):111-20
pubmed: 24862331
J Chem Inf Model. 2016 Dec 27;56(12):2287-2291
pubmed: 27976886
Blood. 2005 Nov 1;106(9):3242-50
pubmed: 16020512
Cell. 2016 Dec 1;167(6):1433-1435
pubmed: 27912049
Somat Cell Mol Genet. 2001 Nov;26(1-6):13-33
pubmed: 12465460
Neurology. 2010 Dec 7;75(23):2087-96
pubmed: 21135382
Mol Biol Cell. 2004 May;15(5):2347-60
pubmed: 15020715
J Neuroinflammation. 2018 Mar 20;15(1):91
pubmed: 29558961
J Neurosci. 2014 Aug 20;34(34):11485-503
pubmed: 25143627
Biochim Biophys Acta. 2010 Mar;1802(3):313-21
pubmed: 20018238
AIDS Rev. 2002 Jan-Mar;4(1):41-9
pubmed: 11998784
ASN Neuro. 2012 Jun 20;4(4):243-52
pubmed: 22591512
Proteome Sci. 2017 Aug 4;15:18
pubmed: 28785172
Eur J Immunol. 2000 Apr;30(4):1120-6
pubmed: 10760801
FASEB J. 2020 Mar;34(3):4147-4162
pubmed: 31950548
Sci China Life Sci. 2016 Aug;59(8):777-91
pubmed: 27430889
Antioxidants (Basel). 2014 Nov 18;3(4):770-97
pubmed: 26785240
Cancer Rep. 2019 Dec;2(6):
pubmed: 31989117
Virology. 2014 May;456-457:1-19
pubmed: 24889220
Annu Rev Cell Dev Biol. 2016 Oct 6;32:223-253
pubmed: 27501449
Nat Cell Biol. 2005 Sep;7(9):847-9
pubmed: 16136179
J Infect Dis. 2012 Jul 15;206(2):275-82
pubmed: 22551810
J Neurochem. 2008 Aug;106(3):1298-313
pubmed: 18485102
EMBO J. 2011 Aug 31;30(17):3481-500
pubmed: 21878991
Redox Biol. 2018 May;15:97-108
pubmed: 29220699
Annu Rev Physiol. 2015;77:57-80
pubmed: 25668017
Front Pharmacol. 2017 Feb 07;8:45
pubmed: 28223936
Curr Biol. 2005 Feb 22;15(4):360-5
pubmed: 15723798
Brain Res. 2019 Nov 1;1722:146389
pubmed: 31425679
Biochemistry. 1992 Dec 8;31(48):12062-8
pubmed: 1457403
AIDS Res Hum Retroviruses. 2015 Mar;31(3):305-12
pubmed: 25291189
J Neurovirol. 2003 Jun;9(3):399-403
pubmed: 12775422
J Chem Inf Model. 2011 Oct 24;51(10):2778-86
pubmed: 21919503
EMBO J. 1991 Jul;10(7):1733-9
pubmed: 2050110
Nat Rev Mol Cell Biol. 2007 Aug;8(8):622-32
pubmed: 17637737
J Neuroimmune Pharmacol. 2021 Jun;16(2):219-237
pubmed: 33751445
Annu Rev Physiol. 2012;74:69-86
pubmed: 22335796
J Biol Chem. 1999 Oct 8;274(41):28837-40
pubmed: 10506122
J Cell Signal. 2021;2(1):63-79
pubmed: 33768214
Curr HIV/AIDS Rep. 2018 Oct;15(5):382-387
pubmed: 30159813
HIV Med. 2015 Nov;16(10):585-90
pubmed: 26238012
FEBS J. 2006 Jul;273(13):3106-17
pubmed: 16762036