Challenges in Comparative Meta-Analysis of the Accuracy of Multiple Diagnostic Tests.

Diagnostic test Indirect comparison Network meta-analysis Sensitivity Specificity Systematic review Test accuracy

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2022
Historique:
entrez: 22 9 2021
pubmed: 23 9 2021
medline: 8 1 2022
Statut: ppublish

Résumé

The rapid increase in diagnostic and screening techniques has urged the need to choose among multiple diagnostic tests. For the majority of diseases, there is more than a single test available, and studies usually compare a subset of these tests. In such cases, a separate meta-analysis of each test cannot provide a reliable answer on the relative accuracy of the multiple available tests. Extensions of standard (hierarchical) meta-analysis to network meta-analysis (NMA) models for the comparison of at least three diagnostic tests have been the subject of methodological research in recent years. NMA can be used to jointly analyze the totality of evidence in order to provide estimates of relative accuracy (sensitivity and specificity ), to compare tests that have not been compared head-to-head, and to obtain a ranking of all competing tests in order to further facilitate the decision-making process.In this chapter, we illustrate current methodology for meta-analysis of multiple test comparisons, introduce NMA methods of diagnostic tests as an extension to the standard meta-analysis of diagnostic test accuracy (DTA) studies, and present existing approaches to rank tests according to their accuracy, specificity , and sensitivity . We also describe the basic concepts, underlying assumptions, and challenges in NMA of multiple diagnostic tests.

Identifiants

pubmed: 34550598
doi: 10.1007/978-1-0716-1566-9_18
doi:

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

299-316

Subventions

Organisme : Department of Health
Pays : United Kingdom

Informations de copyright

© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Areti Angeliki Veroniki (AA)

Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. areti-angeliki.veroniki@unityhealth.to.
Department of Surgery and Cancer, Faculty of Medicine, Institute of Reproductive and Developmental Biology, Imperial College, London, UK. areti-angeliki.veroniki@unityhealth.to.

Sofia Tsokani (S)

Department of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.

Gerta Rücker (G)

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

Dimitris Mavridis (D)

Department of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.
Paris Descartes University, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.

Yemisi Takwoingi (Y)

Test Evaluation Research Group, Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.

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