Highly Efficient Encapsulation of Doxorubicin Hydrochloride in Metal-Organic Frameworks for Synergistic Chemotherapy and Chemodynamic Therapy.

doxorubicin hydrochloride iron-based metal−organic framework loading capacity loading efficiency

Journal

ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670

Informations de publication

Date de publication:
11 10 2021
Historique:
pubmed: 23 9 2021
medline: 25 2 2023
entrez: 22 9 2021
Statut: ppublish

Résumé

Iron-based metal-organic frameworks (MOFs) have been reported to have great potential for encapsulating doxorubicin hydrochloride (DOX), which is a frequently used anthracycline anticancer drug. However, developing a facile approach to realize high loading capacity and efficiency as well as controlled release of DOX in MOFs remains a huge challenge. Herein, we synthesized water-stable MIL-101(Fe)-C

Identifiants

pubmed: 34550683
doi: 10.1021/acsbiomaterials.1c00874
doi:

Substances chimiques

Ferric Compounds 0
Metal-Organic Frameworks 0
Doxorubicin 80168379AG
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4999-5006

Auteurs

Lijia Yao (L)

State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China.

Ying Tang (Y)

State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China.

Wenqian Cao (W)

State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China.

Yuanjing Cui (Y)

State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China.

Guodong Qian (G)

State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China.

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Classifications MeSH