Measles antibody seropositivity among children with allergic diseases: A cross-sectional study in the Japan Environment & Children's Pilot Study.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
01
2021
accepted:
08
09
2021
entrez:
22
9
2021
pubmed:
23
9
2021
medline:
18
11
2021
Statut:
epublish
Résumé
The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population. The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children's Pilot Study [JECS]) of children aged 8 years. The clinical history of allergic diseases, measles, and the concentration of measles immunoglobulin G titers in serum enzyme immunoassay were examined. Fisher's exact tests were used to assess the relationships between the allergic characteristics of the children and their measles antibody positivity rates. This study included 162 children. Any allergic disease was reported in 75 (46.3%). The measles antibody positivity rate was 94.7% among children with any allergic diseases and 92.0% among children without allergic diseases. Our results revealed no differences in measles antibody seropositivity between children with allergies and controls. Children with allergies mount and maintain a comparable immune response to the measles vaccine.
Sections du résumé
BACKGROUND
The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population.
METHODS
The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children's Pilot Study [JECS]) of children aged 8 years. The clinical history of allergic diseases, measles, and the concentration of measles immunoglobulin G titers in serum enzyme immunoassay were examined. Fisher's exact tests were used to assess the relationships between the allergic characteristics of the children and their measles antibody positivity rates.
RESULTS
This study included 162 children. Any allergic disease was reported in 75 (46.3%). The measles antibody positivity rate was 94.7% among children with any allergic diseases and 92.0% among children without allergic diseases. Our results revealed no differences in measles antibody seropositivity between children with allergies and controls.
CONCLUSIONS
Children with allergies mount and maintain a comparable immune response to the measles vaccine.
Identifiants
pubmed: 34551012
doi: 10.1371/journal.pone.0257721
pii: PONE-D-21-00879
pmc: PMC8457502
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0257721Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Cytokine. 2020 Mar 6;130:155051
pubmed: 32151964
J Asthma. 2020 Apr;57(4):381-390
pubmed: 30784333
Ann Allergy Asthma Immunol. 2006 Oct;97(4):469-76
pubmed: 17069101
Vaccine. 2013 Feb 18;31(9):1293-7
pubmed: 23306371
Arch Dermatol. 2004 Dec;140(12):1513-9
pubmed: 15611432
Lancet. 1999 Jan 9;353(9147):98-102
pubmed: 10023894
BMC Public Health. 2014 Jan 10;14:25
pubmed: 24410977
J Med Virol. 2000 Dec;62(4):511-7
pubmed: 11074481
J Infect Dis. 2007 Nov 15;196(10):1433-5
pubmed: 18008219
Hum Vaccin Immunother. 2016;12(1):239-43
pubmed: 26836329
J Allergy Clin Immunol. 2004 Apr;113(4):717-24
pubmed: 15100679