Genetic Polymorphism of
GABRG2
adverse drug reactions
children with epilepsy
gene polymorphism
therapeutic response
valproic acid
Journal
Pharmacogenomics and personalized medicine
ISSN: 1178-7066
Titre abrégé: Pharmgenomics Pers Med
Pays: New Zealand
ID NLM: 101514107
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
07
2021
accepted:
02
09
2021
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
24
9
2021
Statut:
epublish
Résumé
Valproic acid (VPA) is recommended as a first-line treatment for children with epilepsy. The purpose of this study was to explore the association of A retrospective study including 96 Chinese children with epilepsy treated by VPA was carried out. The ADRs were collected during VPA therapy and Among 96 patients, 41 individuals were defined as seizure together with 49 patients with seizure-free and 6 patients unclassified. Carriers of homozygote This study revealed that
Sections du résumé
BACKGROUND
BACKGROUND
Valproic acid (VPA) is recommended as a first-line treatment for children with epilepsy.
OBJECTIVE
OBJECTIVE
The purpose of this study was to explore the association of
METHODS
METHODS
A retrospective study including 96 Chinese children with epilepsy treated by VPA was carried out. The ADRs were collected during VPA therapy and
RESULTS
RESULTS
Among 96 patients, 41 individuals were defined as seizure together with 49 patients with seizure-free and 6 patients unclassified. Carriers of homozygote
CONCLUSION
CONCLUSIONS
This study revealed that
Identifiants
pubmed: 34552348
doi: 10.2147/PGPM.S329594
pii: 329594
pmc: PMC8450188
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1141-1150Informations de copyright
© 2021 Lu et al.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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