Son of a Lesser God: The Case of Cell Therapy for Refractory Angina.
cell therapy
guidelines
meta-analyses
recommendation
refractory angina
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
05
2021
accepted:
02
07
2021
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
24
9
2021
Statut:
epublish
Résumé
In the last decades, various non-pharmacological solutions have been tested on top of medical therapy for the treatment of patients affected by refractory angina (RA). Among these therapeutics, neuromodulation, external counter-pulsation and coronary sinus constriction have been recently introduced in the guidelines for the management of RA in United States and Europe. Notably and paradoxically, although a consistent body of evidence has proposed cell-based therapies (CT) as safe and salutary for RA outcome, CT has not been conversely incorporated into current international guidelines yet. As a matter of fact, published randomized controlled trials (RCT) and meta-analyses (MTA) cumulatively indicated that CT can effectively increase perfusion, physical function and well-being, thus reducing angina symptoms and drug assumption in RA patients. In this review, we (i) provide an updated overview of novel non-pharmacological therapeutics included in current guidelines for the management of patients with RA, (ii) discuss the Level of Evidence stemmed from available clinical trials for each recommended treatment, and (iii) focus on evidence-based CT application for the management of RA.
Identifiants
pubmed: 34552966
doi: 10.3389/fcvm.2021.709795
pmc: PMC8450394
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
709795Informations de copyright
Copyright © 2021 Bassetti, Rurali, Gambini and Pompilio.
Déclaration de conflit d'intérêts
EG is Chief Technology & Operating Officer of Oloker Therapeutics S.r.l. GP is Chairman of the Advisory Board of Oloker Therapeutics S.r.l. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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